Antimicrobial resistance: progress and challenges in antibiotic discovery and anti‐infective therapy
Summary The alarming rise in the emergence of antimicrobial resistance in human, animal and plant pathogens is challenging global health and food production. Traditional strategies used for antibiotic discovery persistently result in the re‐isolation of known compounds, calling for the need to devel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | Microbial Biotechnology |
| Online Access: | https://doi.org/10.1111/1751-7915.13945 |
| _version_ | 1817985896724561920 |
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| author | Tino Krell Miguel A. Matilla |
| author_facet | Tino Krell Miguel A. Matilla |
| author_sort | Tino Krell |
| collection | DOAJ |
| description | Summary The alarming rise in the emergence of antimicrobial resistance in human, animal and plant pathogens is challenging global health and food production. Traditional strategies used for antibiotic discovery persistently result in the re‐isolation of known compounds, calling for the need to develop more rational strategies to identify new antibiotics. Additionally, anti‐infective therapy approaches targeting bacterial signalling pathways related to virulence is emerging as an alternative to the use of antibiotics. In this perspective article, we critically analyse approaches aimed at revitalizing the identification of new antibiotics and to advance antivirulence therapies. The development of high‐throughput in vivo, in vitro and in silico platforms, together with the progress in chemical synthesis, analytical chemistry and structural biology, are reviving a research area that is of tremendous relevance for global health. |
| first_indexed | 2024-04-14T00:03:44Z |
| format | Article |
| id | doaj.art-25e8ebf3c5504fcabec52c955619dcf8 |
| institution | Directory Open Access Journal |
| issn | 1751-7915 |
| language | English |
| last_indexed | 2024-04-14T00:03:44Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Microbial Biotechnology |
| spelling | doaj.art-25e8ebf3c5504fcabec52c955619dcf82022-12-22T02:23:37ZengWileyMicrobial Biotechnology1751-79152022-01-01151707810.1111/1751-7915.13945Antimicrobial resistance: progress and challenges in antibiotic discovery and anti‐infective therapyTino Krell0Miguel A. Matilla1Department of Environmental Protection Estación Experimental del Zaidín Consejo Superior de Investigaciones Científicas Prof. Albareda 1 Granada 18008 SpainDepartment of Environmental Protection Estación Experimental del Zaidín Consejo Superior de Investigaciones Científicas Prof. Albareda 1 Granada 18008 SpainSummary The alarming rise in the emergence of antimicrobial resistance in human, animal and plant pathogens is challenging global health and food production. Traditional strategies used for antibiotic discovery persistently result in the re‐isolation of known compounds, calling for the need to develop more rational strategies to identify new antibiotics. Additionally, anti‐infective therapy approaches targeting bacterial signalling pathways related to virulence is emerging as an alternative to the use of antibiotics. In this perspective article, we critically analyse approaches aimed at revitalizing the identification of new antibiotics and to advance antivirulence therapies. The development of high‐throughput in vivo, in vitro and in silico platforms, together with the progress in chemical synthesis, analytical chemistry and structural biology, are reviving a research area that is of tremendous relevance for global health.https://doi.org/10.1111/1751-7915.13945 |
| spellingShingle | Tino Krell Miguel A. Matilla Antimicrobial resistance: progress and challenges in antibiotic discovery and anti‐infective therapy Microbial Biotechnology |
| title | Antimicrobial resistance: progress and challenges in antibiotic discovery and anti‐infective therapy |
| title_full | Antimicrobial resistance: progress and challenges in antibiotic discovery and anti‐infective therapy |
| title_fullStr | Antimicrobial resistance: progress and challenges in antibiotic discovery and anti‐infective therapy |
| title_full_unstemmed | Antimicrobial resistance: progress and challenges in antibiotic discovery and anti‐infective therapy |
| title_short | Antimicrobial resistance: progress and challenges in antibiotic discovery and anti‐infective therapy |
| title_sort | antimicrobial resistance progress and challenges in antibiotic discovery and anti infective therapy |
| url | https://doi.org/10.1111/1751-7915.13945 |
| work_keys_str_mv | AT tinokrell antimicrobialresistanceprogressandchallengesinantibioticdiscoveryandantiinfectivetherapy AT miguelamatilla antimicrobialresistanceprogressandchallengesinantibioticdiscoveryandantiinfectivetherapy |