Acceptability and feasibility of genital self-sampling for the diagnosis of female genital schistosomiasis: a cross-sectional study in Zambia [version 2; peer review: 2 approved]
Background: Female genital schistosomiasis (FGS) is a neglected and disabling gynaecological disorder that is difficult to diagnose and is part of the wider spectrum of urogenital disease caused by the waterborne parasite Schistosoma haematobium. Over 90% of human schistosomiasis cases are found in...
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| Format: | Article |
| Language: | English |
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Wellcome
2020-09-01
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| Series: | Wellcome Open Research |
| Online Access: | https://wellcomeopenresearch.org/articles/5-61/v2 |
| _version_ | 1819265293388611584 |
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| author | Comfort Rutty Phiri Amy S. Sturt Emily L. Webb Namakau Chola Richard Hayes Kwame Shanaube Helen Ayles Isaiah Hansingo Amaya L. Bustinduy BILHIV study team |
| author_facet | Comfort Rutty Phiri Amy S. Sturt Emily L. Webb Namakau Chola Richard Hayes Kwame Shanaube Helen Ayles Isaiah Hansingo Amaya L. Bustinduy BILHIV study team |
| author_sort | Comfort Rutty Phiri |
| collection | DOAJ |
| description | Background: Female genital schistosomiasis (FGS) is a neglected and disabling gynaecological disorder that is difficult to diagnose and is part of the wider spectrum of urogenital disease caused by the waterborne parasite Schistosoma haematobium. Over 90% of human schistosomiasis cases are found in sub-Saharan Africa with 3.8 million people infected with schistosomes in Zambia. Reported FGS prevalence ranges from 33-75% of those with urinary schistosomiasis in endemic areas, suggesting a potentially high FGS burden in Zambia alone. The Bilharzia and HIV (BILHIV) study evaluated home self-sampling genital collection methods for the diagnosis of FGS. Methods: Eligible participants included non-pregnant, sexually active women aged 18-31 who were previously recruited for the HPTN 071 (PopART) trial in Livingstone, Zambia. Household demographic and symptom questionnaires were administered by community workers. Participants were offered vaginal and cervical self-swabs and a urine cup. Cervicovaginal lavage (CVL) was performed in clinic by midwives. Information was collected from participants on the acceptability and feasibility of genital self-sampling. Results: From January-August 2018, 603 women were enrolled, and 87.3% (527/603) completed clinic follow up. A high proportion of participants indicated that self-collection of specimens was “easy” or “very easy” on a 5-point Likert scale. A high proportion of women would be willing to self-collect all three specimens again in future: vaginal swab 96.7% (583/603), cervical swab 96.5% (582/603), and urine 96.2% (580/603). Overall, 90.0% (543/603) preferred to self-collect samples at home, compared with sampling in the clinic Home-based self-sampling was preferred over provider-based sampling in the clinic due to greater privacy 65.0% (353/543), convenience 51.4% (279/543) and lack of needed transportation 17.7% (96/543). Conclusions: Home based genital self-sampling for FGS diagnosis is highly acceptable. This scalable method may inform future efforts for community-based diagnosis of FGS |
| first_indexed | 2024-12-23T20:43:05Z |
| format | Article |
| id | doaj.art-25ea6ab059384be8b7199dcf493f35db |
| institution | Directory Open Access Journal |
| issn | 2398-502X |
| language | English |
| last_indexed | 2024-12-23T20:43:05Z |
| publishDate | 2020-09-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj.art-25ea6ab059384be8b7199dcf493f35db2022-12-21T17:31:52ZengWellcomeWellcome Open Research2398-502X2020-09-01510.12688/wellcomeopenres.15482.217751Acceptability and feasibility of genital self-sampling for the diagnosis of female genital schistosomiasis: a cross-sectional study in Zambia [version 2; peer review: 2 approved]Comfort Rutty Phiri0Amy S. Sturt1Emily L. Webb2Namakau Chola3Richard Hayes4Kwame Shanaube5Helen Ayles6Isaiah Hansingo7Amaya L. Bustinduy8BILHIV study teamZambart, Lusaka, ZambiaDepartment of Clinical Research, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UKMRC Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UKZambart, Lusaka, ZambiaMRC Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UKZambart, Lusaka, ZambiaDepartment of Clinical Research, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UKGynecology Department, Livingstone Central Hospital, Livingstone, ZambiaDepartment of Clinical Research, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UKBackground: Female genital schistosomiasis (FGS) is a neglected and disabling gynaecological disorder that is difficult to diagnose and is part of the wider spectrum of urogenital disease caused by the waterborne parasite Schistosoma haematobium. Over 90% of human schistosomiasis cases are found in sub-Saharan Africa with 3.8 million people infected with schistosomes in Zambia. Reported FGS prevalence ranges from 33-75% of those with urinary schistosomiasis in endemic areas, suggesting a potentially high FGS burden in Zambia alone. The Bilharzia and HIV (BILHIV) study evaluated home self-sampling genital collection methods for the diagnosis of FGS. Methods: Eligible participants included non-pregnant, sexually active women aged 18-31 who were previously recruited for the HPTN 071 (PopART) trial in Livingstone, Zambia. Household demographic and symptom questionnaires were administered by community workers. Participants were offered vaginal and cervical self-swabs and a urine cup. Cervicovaginal lavage (CVL) was performed in clinic by midwives. Information was collected from participants on the acceptability and feasibility of genital self-sampling. Results: From January-August 2018, 603 women were enrolled, and 87.3% (527/603) completed clinic follow up. A high proportion of participants indicated that self-collection of specimens was “easy” or “very easy” on a 5-point Likert scale. A high proportion of women would be willing to self-collect all three specimens again in future: vaginal swab 96.7% (583/603), cervical swab 96.5% (582/603), and urine 96.2% (580/603). Overall, 90.0% (543/603) preferred to self-collect samples at home, compared with sampling in the clinic Home-based self-sampling was preferred over provider-based sampling in the clinic due to greater privacy 65.0% (353/543), convenience 51.4% (279/543) and lack of needed transportation 17.7% (96/543). Conclusions: Home based genital self-sampling for FGS diagnosis is highly acceptable. This scalable method may inform future efforts for community-based diagnosis of FGShttps://wellcomeopenresearch.org/articles/5-61/v2 |
| spellingShingle | Comfort Rutty Phiri Amy S. Sturt Emily L. Webb Namakau Chola Richard Hayes Kwame Shanaube Helen Ayles Isaiah Hansingo Amaya L. Bustinduy BILHIV study team Acceptability and feasibility of genital self-sampling for the diagnosis of female genital schistosomiasis: a cross-sectional study in Zambia [version 2; peer review: 2 approved] Wellcome Open Research |
| title | Acceptability and feasibility of genital self-sampling for the diagnosis of female genital schistosomiasis: a cross-sectional study in Zambia [version 2; peer review: 2 approved] |
| title_full | Acceptability and feasibility of genital self-sampling for the diagnosis of female genital schistosomiasis: a cross-sectional study in Zambia [version 2; peer review: 2 approved] |
| title_fullStr | Acceptability and feasibility of genital self-sampling for the diagnosis of female genital schistosomiasis: a cross-sectional study in Zambia [version 2; peer review: 2 approved] |
| title_full_unstemmed | Acceptability and feasibility of genital self-sampling for the diagnosis of female genital schistosomiasis: a cross-sectional study in Zambia [version 2; peer review: 2 approved] |
| title_short | Acceptability and feasibility of genital self-sampling for the diagnosis of female genital schistosomiasis: a cross-sectional study in Zambia [version 2; peer review: 2 approved] |
| title_sort | acceptability and feasibility of genital self sampling for the diagnosis of female genital schistosomiasis a cross sectional study in zambia version 2 peer review 2 approved |
| url | https://wellcomeopenresearch.org/articles/5-61/v2 |
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