Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice[S]

Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice[S]

Vitamin D receptor (VDR) mediates vitamin D signaling involved in bone metabolism, cellular growth and differentiation, cardiovascular function, and bile acid regulation. Mice with an intestine-specific disruption of VDR (VdrΔIEpC) have abnormal body size, colon structure, and imbalance of bile acid...

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Bibliographic Details
Main Authors:	Jie Cheng, Zhong-Ze Fang, Jung-Hwan Kim, Kristopher W. Krausz, Naoki Tanaka, JohnY.L. Chiang, Frank J. Gonzalez
Format:	Article
Language:	English
Published:	Elsevier 2014-03-01
Series:	Journal of Lipid Research
Subjects:	bile acids vitamin D receptor metabolomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520376793

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