Indices to measure risk of HIV acquisition in Rakai, Uganda.
Targeting most-at-risk individuals with HIV preventive interventions is cost-effective. We developed gender-specific indices to measure risk of HIV among sexually active individuals in Rakai, Uganda.We used multivariable Cox proportional hazards models to estimate time-to-HIV infection associated wi...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3976261?pdf=render |
| _version_ | 1819127978901110784 |
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| author | Joseph Kagaayi Ronald H Gray Christopher Whalen Pingfu Fu Duncan Neuhauser Janet W McGrath Nelson K Sewankambo David Serwadda Godfrey Kigozi Fred Nalugoda Steven J Reynolds Maria J Wawer Mendel E Singer |
| author_facet | Joseph Kagaayi Ronald H Gray Christopher Whalen Pingfu Fu Duncan Neuhauser Janet W McGrath Nelson K Sewankambo David Serwadda Godfrey Kigozi Fred Nalugoda Steven J Reynolds Maria J Wawer Mendel E Singer |
| author_sort | Joseph Kagaayi |
| collection | DOAJ |
| description | Targeting most-at-risk individuals with HIV preventive interventions is cost-effective. We developed gender-specific indices to measure risk of HIV among sexually active individuals in Rakai, Uganda.We used multivariable Cox proportional hazards models to estimate time-to-HIV infection associated with candidate predictors. Reduced models were determined using backward selection procedures with Akaike's information criterion (AIC) as the stopping rule. Model discrimination was determined using Harrell's concordance index (c index). Model calibration was determined graphically. Nomograms were used to present the final prediction models.We used samples of 7,497 women and 5,783 men. 342 new infections occurred among females (incidence 1.11/100 person years,) and 225 among the males (incidence 1.00/100 person years). The final model for men included age, education, circumcision status, number of sexual partners, genital ulcer disease symptoms, alcohol use before sex, partner in high risk employment, community type, being unaware of a partner's HIV status and community HIV prevalence. The Model's optimism-corrected c index was 69.1 percent (95% CI = 0.66, 0.73). The final women's model included age, marital status, education, number of sex partners, new sex partner, alcohol consumption by self or partner before sex, concurrent sexual partners, being employed in a high-risk occupation, having genital ulcer disease symptoms, community HIV prevalence, and perceiving oneself or partner to be exposed to HIV. The models optimism-corrected c index was 0.67 (95% CI = 0.64, 0.70). Both models were well calibrated.These indices were discriminative and well calibrated. This provides proof-of-concept that population-based HIV risk indices can be developed. Further research to validate these indices for other populations is needed. |
| first_indexed | 2024-12-22T08:20:31Z |
| format | Article |
| id | doaj.art-25ed075ffa6d46c4a3af77504c36f1dc |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T08:20:31Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-25ed075ffa6d46c4a3af77504c36f1dc2022-12-21T18:32:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9201510.1371/journal.pone.0092015Indices to measure risk of HIV acquisition in Rakai, Uganda.Joseph KagaayiRonald H GrayChristopher WhalenPingfu FuDuncan NeuhauserJanet W McGrathNelson K SewankamboDavid SerwaddaGodfrey KigoziFred NalugodaSteven J ReynoldsMaria J WawerMendel E SingerTargeting most-at-risk individuals with HIV preventive interventions is cost-effective. We developed gender-specific indices to measure risk of HIV among sexually active individuals in Rakai, Uganda.We used multivariable Cox proportional hazards models to estimate time-to-HIV infection associated with candidate predictors. Reduced models were determined using backward selection procedures with Akaike's information criterion (AIC) as the stopping rule. Model discrimination was determined using Harrell's concordance index (c index). Model calibration was determined graphically. Nomograms were used to present the final prediction models.We used samples of 7,497 women and 5,783 men. 342 new infections occurred among females (incidence 1.11/100 person years,) and 225 among the males (incidence 1.00/100 person years). The final model for men included age, education, circumcision status, number of sexual partners, genital ulcer disease symptoms, alcohol use before sex, partner in high risk employment, community type, being unaware of a partner's HIV status and community HIV prevalence. The Model's optimism-corrected c index was 69.1 percent (95% CI = 0.66, 0.73). The final women's model included age, marital status, education, number of sex partners, new sex partner, alcohol consumption by self or partner before sex, concurrent sexual partners, being employed in a high-risk occupation, having genital ulcer disease symptoms, community HIV prevalence, and perceiving oneself or partner to be exposed to HIV. The models optimism-corrected c index was 0.67 (95% CI = 0.64, 0.70). Both models were well calibrated.These indices were discriminative and well calibrated. This provides proof-of-concept that population-based HIV risk indices can be developed. Further research to validate these indices for other populations is needed.http://europepmc.org/articles/PMC3976261?pdf=render |
| spellingShingle | Joseph Kagaayi Ronald H Gray Christopher Whalen Pingfu Fu Duncan Neuhauser Janet W McGrath Nelson K Sewankambo David Serwadda Godfrey Kigozi Fred Nalugoda Steven J Reynolds Maria J Wawer Mendel E Singer Indices to measure risk of HIV acquisition in Rakai, Uganda. PLoS ONE |
| title | Indices to measure risk of HIV acquisition in Rakai, Uganda. |
| title_full | Indices to measure risk of HIV acquisition in Rakai, Uganda. |
| title_fullStr | Indices to measure risk of HIV acquisition in Rakai, Uganda. |
| title_full_unstemmed | Indices to measure risk of HIV acquisition in Rakai, Uganda. |
| title_short | Indices to measure risk of HIV acquisition in Rakai, Uganda. |
| title_sort | indices to measure risk of hiv acquisition in rakai uganda |
| url | http://europepmc.org/articles/PMC3976261?pdf=render |
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