The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation

The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation

Due to the advantages of charged particles compared to conventional radiotherapy, a vast increase is noted in the use of particle therapy in the clinic. These advantages include an improved dose deposition and increased biological effectiveness. Metastasis is still an important cause of mortality in...

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Bibliographic Details
Main Authors: Katrien Konings, Charlot Vandevoorde, Niels Belmans, Randy Vermeesen, Bjorn Baselet, Merel Van Walleghem, Ann Janssen, Sofie Isebaert, Sarah Baatout, Karin Haustermans, Marjan Moreels
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Oncology
Subjects:
particle therapy
proton
carbon ion
radiosensitization
Hedgehog pathway
migration
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00391/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00391/full

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