The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters
The objective of this study was to investigate the impact of Lycopene and L-Carnitine, individually or in combination, on various physiological and molecular factors related to intestinal health and absorption ability in Roosters, such as intestinal morphology, serum biochemical parameters, genes in...
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MDPI AG
2023-04-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/8/1274 |
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| author | Wael Ennab Nanwei Ye Haoze Wu Saif Ullah Tavakolikazerooni Hadi Anthony Pius Bassey Sheeraz Mustafa Jingle Jiang Quanwei Wei Fangxiong Shi |
| author_facet | Wael Ennab Nanwei Ye Haoze Wu Saif Ullah Tavakolikazerooni Hadi Anthony Pius Bassey Sheeraz Mustafa Jingle Jiang Quanwei Wei Fangxiong Shi |
| author_sort | Wael Ennab |
| collection | DOAJ |
| description | The objective of this study was to investigate the impact of Lycopene and L-Carnitine, individually or in combination, on various physiological and molecular factors related to intestinal health and absorption ability in Roosters, such as intestinal morphology, serum biochemical parameters, genes involved in Lycopene uptake, nutritional transport genes, and tight junction genes. The findings of the study revealed that the combination of L-Carnitine and Lycopene supplementation had been found to increase the serum concentration levels of TP and ALB. Interestingly, the relative mRNA expression of genes responsible for Lycopene uptakes, such as <i>SR-BI</i> and <i>BCO2</i>, was higher in the LC group compared to other groups. Additionally, the expression of specific nutritional transport genes in the duodenum was significantly affected by both CAR and LC supplementation groups. The tight junction gene <i>OCLN</i> showed a significant increase in expression in the combination group compared to using either Lycopene or L-Carnitine alone. This study concludes that using Lycopene and L-carnitine in combination in poultry feed can potentially improve intestinal morphology and serum biochemical parameters, increase Lycopene bioavailability, improve nutrients uptake, and enhance the integrity of duodenal tight junctions in Roosters. |
| first_indexed | 2024-03-11T05:18:38Z |
| format | Article |
| id | doaj.art-25eeebead92c4168a237c038e2f175be |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-11T05:18:38Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-25eeebead92c4168a237c038e2f175be2023-11-17T17:59:25ZengMDPI AGAnimals2076-26152023-04-01138127410.3390/ani13081274The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of RoostersWael Ennab0Nanwei Ye1Haoze Wu2Saif Ullah3Tavakolikazerooni Hadi4Anthony Pius Bassey5Sheeraz Mustafa6Jingle Jiang7Quanwei Wei8Fangxiong Shi9National Experimental Teaching Demonstration Center of Animal Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaNational Experimental Teaching Demonstration Center of Animal Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaNational Experimental Teaching Demonstration Center of Animal Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaNational Experimental Teaching Demonstration Center of Animal Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaNational Experimental Teaching Demonstration Center of Animal Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaNational Center of Meat Quality and Safety Control, Synergistic Innovation Center of Food Safety and Nutrition, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaFaculty of Veterinary Animal Sciences, Ziauddin University (ZUFVAS), Karachi 75600, PakistanShanghai Endangered Species Conservation and Research Centre, Shanghai Zoo, Shanghai 200335, ChinaNational Experimental Teaching Demonstration Center of Animal Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaNational Experimental Teaching Demonstration Center of Animal Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaThe objective of this study was to investigate the impact of Lycopene and L-Carnitine, individually or in combination, on various physiological and molecular factors related to intestinal health and absorption ability in Roosters, such as intestinal morphology, serum biochemical parameters, genes involved in Lycopene uptake, nutritional transport genes, and tight junction genes. The findings of the study revealed that the combination of L-Carnitine and Lycopene supplementation had been found to increase the serum concentration levels of TP and ALB. Interestingly, the relative mRNA expression of genes responsible for Lycopene uptakes, such as <i>SR-BI</i> and <i>BCO2</i>, was higher in the LC group compared to other groups. Additionally, the expression of specific nutritional transport genes in the duodenum was significantly affected by both CAR and LC supplementation groups. The tight junction gene <i>OCLN</i> showed a significant increase in expression in the combination group compared to using either Lycopene or L-Carnitine alone. This study concludes that using Lycopene and L-carnitine in combination in poultry feed can potentially improve intestinal morphology and serum biochemical parameters, increase Lycopene bioavailability, improve nutrients uptake, and enhance the integrity of duodenal tight junctions in Roosters.https://www.mdpi.com/2076-2615/13/8/1274lycopeneL-Carnitineantioxidants combinationlycopene bioavailabilityroosters |
| spellingShingle | Wael Ennab Nanwei Ye Haoze Wu Saif Ullah Tavakolikazerooni Hadi Anthony Pius Bassey Sheeraz Mustafa Jingle Jiang Quanwei Wei Fangxiong Shi The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters Animals lycopene L-Carnitine antioxidants combination lycopene bioavailability roosters |
| title | The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters |
| title_full | The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters |
| title_fullStr | The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters |
| title_full_unstemmed | The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters |
| title_short | The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters |
| title_sort | synergistic effects of the combination of l carnitine and lycopene on the lycopene bioavailability and duodenal health of roosters |
| topic | lycopene L-Carnitine antioxidants combination lycopene bioavailability roosters |
| url | https://www.mdpi.com/2076-2615/13/8/1274 |
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