Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias
Na<sub>v</sub>1.5 is the predominant cardiac sodium channel subtype, encoded by the <i>SCN5A</i> gene, which is involved in the initiation and conduction of action potentials throughout the heart. Along its biosynthesis process, Na<sub>v</sub>1.5 undergoes strict...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/3/1381 |
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| author | Houria Daimi Estefanía Lozano-Velasco Amelia Aranega Diego Franco |
| author_facet | Houria Daimi Estefanía Lozano-Velasco Amelia Aranega Diego Franco |
| author_sort | Houria Daimi |
| collection | DOAJ |
| description | Na<sub>v</sub>1.5 is the predominant cardiac sodium channel subtype, encoded by the <i>SCN5A</i> gene, which is involved in the initiation and conduction of action potentials throughout the heart. Along its biosynthesis process, Na<sub>v</sub>1.5 undergoes strict genomic and non-genomic regulatory and quality control steps that allow only newly synthesized channels to reach their final membrane destination and carry out their electrophysiological role. These regulatory pathways are ensured by distinct interacting proteins that accompany the nascent Na<sub>v</sub>1.5 protein along with different subcellular organelles. Defects on a large number of these pathways have a tremendous impact on Na<sub>v</sub>1.5 functionality and are thus intimately linked to cardiac arrhythmias. In the present review, we provide current state-of-the-art information on the molecular events that regulate <i>SCN5A</i>/Na<sub>v</sub>1.5 and the cardiac channelopathies associated with defects in these pathways. |
| first_indexed | 2024-03-09T23:47:28Z |
| format | Article |
| id | doaj.art-25ef2f7e320a4fbba67a95baa63bbbf2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:47:28Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-25ef2f7e320a4fbba67a95baa63bbbf22023-11-23T16:39:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-01233138110.3390/ijms23031381Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac ArrhythmiasHouria Daimi0Estefanía Lozano-Velasco1Amelia Aranega2Diego Franco3Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, University of Monastir, Monastir 5000, TunisiaDepartment of Experimental Biology, University of Jaen, 23071 Jaen, SpainDepartment of Experimental Biology, University of Jaen, 23071 Jaen, SpainDepartment of Experimental Biology, University of Jaen, 23071 Jaen, SpainNa<sub>v</sub>1.5 is the predominant cardiac sodium channel subtype, encoded by the <i>SCN5A</i> gene, which is involved in the initiation and conduction of action potentials throughout the heart. Along its biosynthesis process, Na<sub>v</sub>1.5 undergoes strict genomic and non-genomic regulatory and quality control steps that allow only newly synthesized channels to reach their final membrane destination and carry out their electrophysiological role. These regulatory pathways are ensured by distinct interacting proteins that accompany the nascent Na<sub>v</sub>1.5 protein along with different subcellular organelles. Defects on a large number of these pathways have a tremendous impact on Na<sub>v</sub>1.5 functionality and are thus intimately linked to cardiac arrhythmias. In the present review, we provide current state-of-the-art information on the molecular events that regulate <i>SCN5A</i>/Na<sub>v</sub>1.5 and the cardiac channelopathies associated with defects in these pathways.https://www.mdpi.com/1422-0067/23/3/1381cardiac sodium channelgene regulationcardiac arrhythmias |
| spellingShingle | Houria Daimi Estefanía Lozano-Velasco Amelia Aranega Diego Franco Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias International Journal of Molecular Sciences cardiac sodium channel gene regulation cardiac arrhythmias |
| title | Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias |
| title_full | Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias |
| title_fullStr | Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias |
| title_full_unstemmed | Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias |
| title_short | Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias |
| title_sort | genomic and non genomic regulatory mechanisms of the cardiac sodium channel in cardiac arrhythmias |
| topic | cardiac sodium channel gene regulation cardiac arrhythmias |
| url | https://www.mdpi.com/1422-0067/23/3/1381 |
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