Tailoring Tfh profiles enhances antibody persistence to a clade C HIV-1 vaccine in rhesus macaques

Tailoring Tfh profiles enhances antibody persistence to a clade C HIV-1 vaccine in rhesus macaques

CD4 T follicular helper cells (Tfh) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response. Insights into Tfh subsets that promote antibody persistence and functional capacity can critically inform vacc...

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Bibliographic Details
Main Authors: Anil Verma, Chase E Hawes, Sonny R Elizaldi, Justin C Smith, Dhivyaa Rajasundaram, Gabriel Kristian Pedersen, Xiaoying Shen, LaTonya D Williams, Georgia D Tomaras, Pamela A Kozlowski, Rama R Amara, Smita S Iyer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-02-01
Series:eLife
Subjects:
T-dependent B cell response
antibody persistence
vaccine efficacy
Online Access:https://elifesciences.org/articles/89395

Internet

https://elifesciences.org/articles/89395

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