Signaling of the Purinergic System in the Joint
The joint is a complex anatomical structure consisting of different tissues, each with a particular feature, playing together to give mobility and stability at the body. All the joints have a similar composition including cartilage for reducing the friction of the movement and protecting the underly...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.01591/full |
| _version_ | 1818857849092046848 |
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| author | Carmen Corciulo Carmen Corciulo Bruce N. Cronstein Bruce N. Cronstein |
| author_facet | Carmen Corciulo Carmen Corciulo Bruce N. Cronstein Bruce N. Cronstein |
| author_sort | Carmen Corciulo |
| collection | DOAJ |
| description | The joint is a complex anatomical structure consisting of different tissues, each with a particular feature, playing together to give mobility and stability at the body. All the joints have a similar composition including cartilage for reducing the friction of the movement and protecting the underlying bone, a synovial membrane that produces synovial fluid to lubricate the joint, ligaments to limit joint movement, and tendons for the interaction with muscles. Direct or indirect damage of one or more of the tissues forming the joint is the foundation of different pathological conditions. Many molecular mechanisms are involved in maintaining the joint homeostasis as well as in triggering disease development. The molecular pathway activated by the purinergic system is one of them.The purinergic signaling defines a group of receptors and intermembrane channels activated by adenosine, adenosine diphosphate, adenosine 5’-triphosphate, uridine triphosphate, and uridine diphosphate. It has been largely described as a modulator of many physiological and pathological conditions including rheumatic diseases. Here we will give an overview of the purinergic system in the joint describing its expression and function in the synovium, cartilage, ligament, tendon, and bone with a therapeutic perspective. |
| first_indexed | 2024-12-19T08:46:55Z |
| format | Article |
| id | doaj.art-25f0fdc0414c45a0b859eebe44f0aee3 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-19T08:46:55Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-25f0fdc0414c45a0b859eebe44f0aee32022-12-21T20:28:48ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-01-011010.3389/fphar.2019.01591488973Signaling of the Purinergic System in the JointCarmen Corciulo0Carmen Corciulo1Bruce N. Cronstein2Bruce N. Cronstein3Division of Translational Medicine, Department of Medicine, NYU School of Medicine, New York, NY, United StatesKrefting Research Centre—Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, SwedenDivision of Translational Medicine, Department of Medicine, NYU School of Medicine, New York, NY, United StatesDivision of Rheumatology, Department of Medicine, NYU School of Medicine, New York, NY, United StatesThe joint is a complex anatomical structure consisting of different tissues, each with a particular feature, playing together to give mobility and stability at the body. All the joints have a similar composition including cartilage for reducing the friction of the movement and protecting the underlying bone, a synovial membrane that produces synovial fluid to lubricate the joint, ligaments to limit joint movement, and tendons for the interaction with muscles. Direct or indirect damage of one or more of the tissues forming the joint is the foundation of different pathological conditions. Many molecular mechanisms are involved in maintaining the joint homeostasis as well as in triggering disease development. The molecular pathway activated by the purinergic system is one of them.The purinergic signaling defines a group of receptors and intermembrane channels activated by adenosine, adenosine diphosphate, adenosine 5’-triphosphate, uridine triphosphate, and uridine diphosphate. It has been largely described as a modulator of many physiological and pathological conditions including rheumatic diseases. Here we will give an overview of the purinergic system in the joint describing its expression and function in the synovium, cartilage, ligament, tendon, and bone with a therapeutic perspective.https://www.frontiersin.org/article/10.3389/fphar.2019.01591/fulladenosinecartilagebonesynoviumtendonpurine |
| spellingShingle | Carmen Corciulo Carmen Corciulo Bruce N. Cronstein Bruce N. Cronstein Signaling of the Purinergic System in the Joint Frontiers in Pharmacology adenosine cartilage bone synovium tendon purine |
| title | Signaling of the Purinergic System in the Joint |
| title_full | Signaling of the Purinergic System in the Joint |
| title_fullStr | Signaling of the Purinergic System in the Joint |
| title_full_unstemmed | Signaling of the Purinergic System in the Joint |
| title_short | Signaling of the Purinergic System in the Joint |
| title_sort | signaling of the purinergic system in the joint |
| topic | adenosine cartilage bone synovium tendon purine |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.01591/full |
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