C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code
The restoration of genetic code by editing mutated genes is a potential method for the treatment of genetic diseases/disorders. Genetic disorders are caused by the point mutations of thymine (T) to cytidine (C) or guanosine (G) to adenine (A), for which gene editing (editing of mutated genes) is a p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/9/1636 |
| _version_ | 1797487956856930304 |
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| author | Sonali Bhakta Toshifumi Tsukahara |
| author_facet | Sonali Bhakta Toshifumi Tsukahara |
| author_sort | Sonali Bhakta |
| collection | DOAJ |
| description | The restoration of genetic code by editing mutated genes is a potential method for the treatment of genetic diseases/disorders. Genetic disorders are caused by the point mutations of thymine (T) to cytidine (C) or guanosine (G) to adenine (A), for which gene editing (editing of mutated genes) is a promising therapeutic technique. In C-to-Uridine (U) RNA editing, it converts the base C-to-U in RNA molecules and leads to nonsynonymous changes when occurring in coding regions; however, for G-to-A mutations, A-to-I editing occurs. Editing of C-to-U is not as physiologically common as that of A-to-I editing. Although hundreds to thousands of coding sites have been found to be C-to-U edited or editable in humans, the biological significance of this phenomenon remains elusive. In this review, we have tried to provide detailed information on physiological and artificial approaches for C-to-U RNA editing. |
| first_indexed | 2024-03-09T23:55:13Z |
| format | Article |
| id | doaj.art-25f22effdb944b98903ab721f035ef70 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T23:55:13Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-25f22effdb944b98903ab721f035ef702023-11-23T16:25:31ZengMDPI AGGenes2073-44252022-09-01139163610.3390/genes13091636C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic CodeSonali Bhakta0Toshifumi Tsukahara1Bioscience and Biotechnology, School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology (JAIST), 1-1 Asahidai, Nomi City 923-1292, JapanBioscience and Biotechnology, School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology (JAIST), 1-1 Asahidai, Nomi City 923-1292, JapanThe restoration of genetic code by editing mutated genes is a potential method for the treatment of genetic diseases/disorders. Genetic disorders are caused by the point mutations of thymine (T) to cytidine (C) or guanosine (G) to adenine (A), for which gene editing (editing of mutated genes) is a promising therapeutic technique. In C-to-Uridine (U) RNA editing, it converts the base C-to-U in RNA molecules and leads to nonsynonymous changes when occurring in coding regions; however, for G-to-A mutations, A-to-I editing occurs. Editing of C-to-U is not as physiologically common as that of A-to-I editing. Although hundreds to thousands of coding sites have been found to be C-to-U edited or editable in humans, the biological significance of this phenomenon remains elusive. In this review, we have tried to provide detailed information on physiological and artificial approaches for C-to-U RNA editing.https://www.mdpi.com/2073-4425/13/9/1636RNA editing 1cytidine 2thymine 3uridine 4mutation 5genetic disease 6 |
| spellingShingle | Sonali Bhakta Toshifumi Tsukahara C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code Genes RNA editing 1 cytidine 2 thymine 3 uridine 4 mutation 5 genetic disease 6 |
| title | C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code |
| title_full | C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code |
| title_fullStr | C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code |
| title_full_unstemmed | C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code |
| title_short | C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code |
| title_sort | c to u rna editing a site directed rna editing tool for restoration of genetic code |
| topic | RNA editing 1 cytidine 2 thymine 3 uridine 4 mutation 5 genetic disease 6 |
| url | https://www.mdpi.com/2073-4425/13/9/1636 |
| work_keys_str_mv | AT sonalibhakta ctournaeditingasitedirectedrnaeditingtoolforrestorationofgeneticcode AT toshifumitsukahara ctournaeditingasitedirectedrnaeditingtoolforrestorationofgeneticcode |