Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19
Abstract In a multicenter European retrospective study including 162 patients with COVID-19 occurring in essential thrombocythemia (ET, n = 48), polycythemia vera (PV, n = 42), myelofibrosis (MF, n = 56), and prefibrotic myelofibrosis (pre-PMF, n = 16), 15 major thromboses (3 arterial and 12 venous)...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-02-01
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| Series: | Blood Cancer Journal |
| Online Access: | https://doi.org/10.1038/s41408-021-00417-3 |
| _version_ | 1818677077249884160 |
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| author | Tiziano Barbui Valerio De Stefano Alberto Alvarez-Larran Alessandra Iurlo Arianna Masciulli Alessandra Carobbio Arianna Ghirardi Alberto Ferrari Valeria Cancelli Elena Maria Elli Marcio Miguel Andrade-Campos Mercedes Gasior Kabat Jean-Jaques Kiladjian Francesca Palandri Giulia Benevolo Valentin Garcia-Gutierrez Maria Laura Fox Maria Angeles Foncillas Carmen Montoya Morcillo Elisa Rumi Santiago Osorio Petros Papadopoulos Massimiliano Bonifacio Keina Susana Quiroz Cervantes Miguel Sagues Serrano Gonzalo Carreno-Tarragona Marta Anna Sobas Francesca Lunghi Andrea Patriarca Begoña Navas Elorza Anna Angona Elena Magro Mazo Steffen Koschmieder Giuseppe Carli Beatriz Cuevas Juan Carlos Hernandez-Boluda Emma Lopez Abadia Blanca Xicoy Cirici Paola Guglielmelli Marta Garrote Daniele Cattaneo Rosa Daffini Fabrizio Cavalca Beatriz Bellosillo Lina Benajiba Natalia Curto-Garcia Marta Bellini Silvia Betti Claire Harrison Alessandro Rambaldi Alessandro Maria Vannucchi |
| author_facet | Tiziano Barbui Valerio De Stefano Alberto Alvarez-Larran Alessandra Iurlo Arianna Masciulli Alessandra Carobbio Arianna Ghirardi Alberto Ferrari Valeria Cancelli Elena Maria Elli Marcio Miguel Andrade-Campos Mercedes Gasior Kabat Jean-Jaques Kiladjian Francesca Palandri Giulia Benevolo Valentin Garcia-Gutierrez Maria Laura Fox Maria Angeles Foncillas Carmen Montoya Morcillo Elisa Rumi Santiago Osorio Petros Papadopoulos Massimiliano Bonifacio Keina Susana Quiroz Cervantes Miguel Sagues Serrano Gonzalo Carreno-Tarragona Marta Anna Sobas Francesca Lunghi Andrea Patriarca Begoña Navas Elorza Anna Angona Elena Magro Mazo Steffen Koschmieder Giuseppe Carli Beatriz Cuevas Juan Carlos Hernandez-Boluda Emma Lopez Abadia Blanca Xicoy Cirici Paola Guglielmelli Marta Garrote Daniele Cattaneo Rosa Daffini Fabrizio Cavalca Beatriz Bellosillo Lina Benajiba Natalia Curto-Garcia Marta Bellini Silvia Betti Claire Harrison Alessandro Rambaldi Alessandro Maria Vannucchi |
| author_sort | Tiziano Barbui |
| collection | DOAJ |
| description | Abstract In a multicenter European retrospective study including 162 patients with COVID-19 occurring in essential thrombocythemia (ET, n = 48), polycythemia vera (PV, n = 42), myelofibrosis (MF, n = 56), and prefibrotic myelofibrosis (pre-PMF, n = 16), 15 major thromboses (3 arterial and 12 venous) were registered in 14 patients, of whom all, but one, were receiving LMW-heparin prophylaxis. After adjustment for the competing risk of death, the cumulative incidence of arterial and venous thromboembolic events (VTE) reached 8.5% after 60 days follow-up. Of note, 8 of 12 VTE were seen in ET. Interestingly, at COVID-19 diagnosis, MPN patients had significantly lower platelet count (p < 0.0001) than in the pre-COVID last follow-up.This decline was remarkably higher in ET (−23.3%, p < 0.0001) than in PV (−16.4%, p = 0.1730) and was associated with higher mortality rate (p = 0.0010) for pneumonia. The effects of possible predictors of thrombosis, selected from those clinically relevant and statistically significant in univariate analysis, were examined in a multivariate model. Independent risk factors were transfer to ICU (SHR = 3.73, p = 0.029), neutrophil/lymphocyte ratio (SHR = 1.1, p = 0.001) and ET phenotype (SHR = 4.37, p = 0.006). The enhanced susceptibility to ET-associated VTE and the associated higher mortality for pneumonia may recognize a common biological plausibility and deserve to be delved to tailor new antithrombotic regimens including antiplatelet drugs. |
| first_indexed | 2024-12-17T08:53:38Z |
| format | Article |
| id | doaj.art-25f622843f2b4b81bf03b1eba9825a5f |
| institution | Directory Open Access Journal |
| issn | 2044-5385 |
| language | English |
| last_indexed | 2024-12-17T08:53:38Z |
| publishDate | 2021-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Blood Cancer Journal |
| spelling | doaj.art-25f622843f2b4b81bf03b1eba9825a5f2022-12-21T21:56:01ZengNature Publishing GroupBlood Cancer Journal2044-53852021-02-0111211110.1038/s41408-021-00417-3Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19Tiziano Barbui0Valerio De Stefano1Alberto Alvarez-Larran2Alessandra Iurlo3Arianna Masciulli4Alessandra Carobbio5Arianna Ghirardi6Alberto Ferrari7Valeria Cancelli8Elena Maria Elli9Marcio Miguel Andrade-Campos10Mercedes Gasior Kabat11Jean-Jaques Kiladjian12Francesca Palandri13Giulia Benevolo14Valentin Garcia-Gutierrez15Maria Laura Fox16Maria Angeles Foncillas17Carmen Montoya Morcillo18Elisa Rumi19Santiago Osorio20Petros Papadopoulos21Massimiliano Bonifacio22Keina Susana Quiroz Cervantes23Miguel Sagues Serrano24Gonzalo Carreno-Tarragona25Marta Anna Sobas26Francesca Lunghi27Andrea Patriarca28Begoña Navas Elorza29Anna Angona30Elena Magro Mazo31Steffen Koschmieder32Giuseppe Carli33Beatriz Cuevas34Juan Carlos Hernandez-Boluda35Emma Lopez Abadia36Blanca Xicoy Cirici37Paola Guglielmelli38Marta Garrote39Daniele Cattaneo40Rosa Daffini41Fabrizio Cavalca42Beatriz Bellosillo43Lina Benajiba44Natalia Curto-Garcia45Marta Bellini46Silvia Betti47Claire Harrison48Alessandro Rambaldi49Alessandro Maria Vannucchi50FROM Research Foundation, Papa Giovanni XXIII HospitalSection of Hematology, Department of Radiological and Hematological Sciences, Catholic University, Fondazione Policlinico “A. Gemelli” IRCCSHospital Clinic de BarcelonaHematology Division, Foundation IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoFROM Research Foundation, Papa Giovanni XXIII HospitalFROM Research Foundation, Papa Giovanni XXIII HospitalFROM Research Foundation, Papa Giovanni XXIII HospitalFROM Research Foundation, Papa Giovanni XXIII HospitalSpedali CiviliHematology Division and Bone Marrow Transplant, San Gerardo Hospital, ASST MonzaHospital del Mar – IMIMHospital Universitario la PazHospital Saint-LouisAzienda Ospedaliero-Universitaria di BolognaAOU Città della Salute e della Scienza di TorinoHospital Ramon y Cajal, IRYCISDepartment of Hematology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Hospital UniversitariHospital Universitario Infanta LeonorHospital General Universitario de AlbaceteDepartment of molecular medicine, University of PaviaHospital Gregorio MaranonHospital Clinico San CarlosOspedale Policlinico “G.B. Rossi”, Borgo RomaHospital Universitario de MostolesICO L’Hospitalet-Hospital Moises Broggi, Sant Joan DespìHospital Universitario 12 de OctubreDepartment of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical UniversityIRCCS Ospedale San RaffaeleAOU Maggiore della CaritàHospital MoncloaICO Girona Hospital Josep TruetaHospital Universitario Principe de AsturiasDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen UniversityOspedale San BortoloHospital Universitario de BurgosHospital Clinico Universitario, INCLIVAHospital General de Elche, ElcheInstitut Català d’Oncologia-Hospital Germans Trias i Pujol, Joseo Carreras Leukemia Research Institute, Badalona (Barcelona) Spain, Universitat Autònoma de BarcelonaCenter Research and Innovation of Myeloproliferative Neoplasms (CRIMM), Department of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, University of FlorenceHospital Clinic de BarcelonaHematology Division, Foundation IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoSpedali CiviliHematology Division and Bone Marrow Transplant, San Gerardo Hospital, ASST MonzaHospital del Mar – IMIMHospital Saint-LouisGuy’s and St. Thomas’ NHS Foundation TrustASST Papa Giovanni XXIIISection of Hematology, Department of Radiological and Hematological Sciences, Catholic University, Fondazione Policlinico “A. Gemelli” IRCCSGuy’s and St. Thomas’ NHS Foundation TrustASST Papa Giovanni XXIIICenter Research and Innovation of Myeloproliferative Neoplasms (CRIMM), Department of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, University of FlorenceAbstract In a multicenter European retrospective study including 162 patients with COVID-19 occurring in essential thrombocythemia (ET, n = 48), polycythemia vera (PV, n = 42), myelofibrosis (MF, n = 56), and prefibrotic myelofibrosis (pre-PMF, n = 16), 15 major thromboses (3 arterial and 12 venous) were registered in 14 patients, of whom all, but one, were receiving LMW-heparin prophylaxis. After adjustment for the competing risk of death, the cumulative incidence of arterial and venous thromboembolic events (VTE) reached 8.5% after 60 days follow-up. Of note, 8 of 12 VTE were seen in ET. Interestingly, at COVID-19 diagnosis, MPN patients had significantly lower platelet count (p < 0.0001) than in the pre-COVID last follow-up.This decline was remarkably higher in ET (−23.3%, p < 0.0001) than in PV (−16.4%, p = 0.1730) and was associated with higher mortality rate (p = 0.0010) for pneumonia. The effects of possible predictors of thrombosis, selected from those clinically relevant and statistically significant in univariate analysis, were examined in a multivariate model. Independent risk factors were transfer to ICU (SHR = 3.73, p = 0.029), neutrophil/lymphocyte ratio (SHR = 1.1, p = 0.001) and ET phenotype (SHR = 4.37, p = 0.006). The enhanced susceptibility to ET-associated VTE and the associated higher mortality for pneumonia may recognize a common biological plausibility and deserve to be delved to tailor new antithrombotic regimens including antiplatelet drugs.https://doi.org/10.1038/s41408-021-00417-3 |
| spellingShingle | Tiziano Barbui Valerio De Stefano Alberto Alvarez-Larran Alessandra Iurlo Arianna Masciulli Alessandra Carobbio Arianna Ghirardi Alberto Ferrari Valeria Cancelli Elena Maria Elli Marcio Miguel Andrade-Campos Mercedes Gasior Kabat Jean-Jaques Kiladjian Francesca Palandri Giulia Benevolo Valentin Garcia-Gutierrez Maria Laura Fox Maria Angeles Foncillas Carmen Montoya Morcillo Elisa Rumi Santiago Osorio Petros Papadopoulos Massimiliano Bonifacio Keina Susana Quiroz Cervantes Miguel Sagues Serrano Gonzalo Carreno-Tarragona Marta Anna Sobas Francesca Lunghi Andrea Patriarca Begoña Navas Elorza Anna Angona Elena Magro Mazo Steffen Koschmieder Giuseppe Carli Beatriz Cuevas Juan Carlos Hernandez-Boluda Emma Lopez Abadia Blanca Xicoy Cirici Paola Guglielmelli Marta Garrote Daniele Cattaneo Rosa Daffini Fabrizio Cavalca Beatriz Bellosillo Lina Benajiba Natalia Curto-Garcia Marta Bellini Silvia Betti Claire Harrison Alessandro Rambaldi Alessandro Maria Vannucchi Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19 Blood Cancer Journal |
| title | Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19 |
| title_full | Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19 |
| title_fullStr | Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19 |
| title_full_unstemmed | Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19 |
| title_short | Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19 |
| title_sort | among classic myeloproliferative neoplasms essential thrombocythemia is associated with the greatest risk of venous thromboembolism during covid 19 |
| url | https://doi.org/10.1038/s41408-021-00417-3 |
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