N-Alkynyl Derivatives of 5-Fluorouracil: Susceptibility to Palladium-Mediated Dealkylation and Toxigenicity in Cancer Cell Culture

N-Alkynyl Derivatives of 5-Fluorouracil: Susceptibility to Palladium-Mediated Dealkylation and Toxigenicity in Cancer Cell Culture

Palladium-activated prodrug therapy is an experimental therapeutic approach that relies on the unique chemical properties and biocompatibility of heterogeneous palladium catalysis to enable the spatially-controlled in vivo conversion of a biochemically-stable prodrug into its active form. This strat...

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Bibliographic Details
Main Authors: Jason T Weiss, Craig eFraser, Belén eRubio-Ruiz, Samuel eMyers, Richard eCrispin, John C Dawson, Valerie G Brunton, E Elizabeth Patton, Neil O Carragher, Asier eUnciti-Broceta
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Chemistry
Subjects:
Palladium
Prodrugs
chemotherapeutics
5-fluorouracil
bioorthogonal chemistry
Online Access:http://journal.frontiersin.org/Journal/10.3389/fchem.2014.00056/full

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