Fabrication of Interface Engineered S‐Scheme Heterojunction Nanocatalyst for Ultrasound‐Triggered Sustainable Cancer Therapy
Abstract In order to establish a set of perfect heterojunction designs and characterization schemes, step‐scheme (S‐scheme) BiOBr@Bi2S3 nanoheterojunctions that enable the charge separation and expand the scope of catalytic reactions, aiming to promote the development and improvement of heterojuncti...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202308546 |
| _version_ | 1797202516322025472 |
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| author | Meng Yuan Ling Yang Zhuang Yang Zhizi Ma Jie Ma Zhendong Liu Ping'an Ma Ziyong Cheng Aziz Maleki Jun Lin |
| author_facet | Meng Yuan Ling Yang Zhuang Yang Zhizi Ma Jie Ma Zhendong Liu Ping'an Ma Ziyong Cheng Aziz Maleki Jun Lin |
| author_sort | Meng Yuan |
| collection | DOAJ |
| description | Abstract In order to establish a set of perfect heterojunction designs and characterization schemes, step‐scheme (S‐scheme) BiOBr@Bi2S3 nanoheterojunctions that enable the charge separation and expand the scope of catalytic reactions, aiming to promote the development and improvement of heterojunction engineering is developed. In this kind of heterojunction system, the Fermi levels mediate the formation of the internal electric field at the interface and guide the recombination of the weak redox carriers, while the strong redox carriers are retained. Thus, these high‐energy electrons and holes are able to catalyze a variety of substrates in the tumor microenvironment, such as the reduction of oxygen and carbon dioxide to superoxide radicals and carbon monoxide (CO), and the oxidation of H2O to hydroxyl radicals, thus achieving sonodynamic therapy and CO combined therapy. Mechanistically, the generated reactive oxygen species and CO damage DNA and inhibit cancer cell energy levels, respectively, to synergistically induce tumor cell apoptosis. This study provides new insights into the realization of high efficiency and low toxicity in catalytic therapy from a unique perspective of materials design. It is anticipated that this catalytic therapeutic method will garner significant interest in the sonocatalytic nanomedicine field. |
| first_indexed | 2024-04-24T08:04:41Z |
| format | Article |
| id | doaj.art-25f91d6f219948b79b1c4e809e7f0e35 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-24T08:04:41Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-25f91d6f219948b79b1c4e809e7f0e352024-04-17T12:48:22ZengWileyAdvanced Science2198-38442024-04-011115n/an/a10.1002/advs.202308546Fabrication of Interface Engineered S‐Scheme Heterojunction Nanocatalyst for Ultrasound‐Triggered Sustainable Cancer TherapyMeng Yuan0Ling Yang1Zhuang Yang2Zhizi Ma3Jie Ma4Zhendong Liu5Ping'an Ma6Ziyong Cheng7Aziz Maleki8Jun Lin9State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 ChinaState Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 ChinaState Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 ChinaState Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 ChinaState Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 ChinaState Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 ChinaState Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 ChinaKey Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University Harbin 150001 ChinaZanjan Pharmaceutical Nanotechnology Research Center (ZPNRC) and Department of Pharmaceutical Nanotechnology (School of pharmacy) Zanjan University of Medical Sciences Zanjan 4513956184 IranState Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 ChinaAbstract In order to establish a set of perfect heterojunction designs and characterization schemes, step‐scheme (S‐scheme) BiOBr@Bi2S3 nanoheterojunctions that enable the charge separation and expand the scope of catalytic reactions, aiming to promote the development and improvement of heterojunction engineering is developed. In this kind of heterojunction system, the Fermi levels mediate the formation of the internal electric field at the interface and guide the recombination of the weak redox carriers, while the strong redox carriers are retained. Thus, these high‐energy electrons and holes are able to catalyze a variety of substrates in the tumor microenvironment, such as the reduction of oxygen and carbon dioxide to superoxide radicals and carbon monoxide (CO), and the oxidation of H2O to hydroxyl radicals, thus achieving sonodynamic therapy and CO combined therapy. Mechanistically, the generated reactive oxygen species and CO damage DNA and inhibit cancer cell energy levels, respectively, to synergistically induce tumor cell apoptosis. This study provides new insights into the realization of high efficiency and low toxicity in catalytic therapy from a unique perspective of materials design. It is anticipated that this catalytic therapeutic method will garner significant interest in the sonocatalytic nanomedicine field.https://doi.org/10.1002/advs.202308546CO therapySDTsonocatalysisS‐scheme heterojunction |
| spellingShingle | Meng Yuan Ling Yang Zhuang Yang Zhizi Ma Jie Ma Zhendong Liu Ping'an Ma Ziyong Cheng Aziz Maleki Jun Lin Fabrication of Interface Engineered S‐Scheme Heterojunction Nanocatalyst for Ultrasound‐Triggered Sustainable Cancer Therapy Advanced Science CO therapy SDT sonocatalysis S‐scheme heterojunction |
| title | Fabrication of Interface Engineered S‐Scheme Heterojunction Nanocatalyst for Ultrasound‐Triggered Sustainable Cancer Therapy |
| title_full | Fabrication of Interface Engineered S‐Scheme Heterojunction Nanocatalyst for Ultrasound‐Triggered Sustainable Cancer Therapy |
| title_fullStr | Fabrication of Interface Engineered S‐Scheme Heterojunction Nanocatalyst for Ultrasound‐Triggered Sustainable Cancer Therapy |
| title_full_unstemmed | Fabrication of Interface Engineered S‐Scheme Heterojunction Nanocatalyst for Ultrasound‐Triggered Sustainable Cancer Therapy |
| title_short | Fabrication of Interface Engineered S‐Scheme Heterojunction Nanocatalyst for Ultrasound‐Triggered Sustainable Cancer Therapy |
| title_sort | fabrication of interface engineered s scheme heterojunction nanocatalyst for ultrasound triggered sustainable cancer therapy |
| topic | CO therapy SDT sonocatalysis S‐scheme heterojunction |
| url | https://doi.org/10.1002/advs.202308546 |
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