Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection

Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection

Bacterial infection tendentiously triggers inflammasome activation, whereas the roles of inflammasome activation in host defense against diverse infections remain unclear. Here, we identified that an ASC-dependent inflammasome activation played opposite roles in host defense against Francisella novi...

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Bibliographic Details
Main Authors: Yu Guo, Rudi Mao, Qingqing Xie, Xiaojie Cheng, Tao Xu, Xiaoyuan Wang, Yan Du, Xiaopeng Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Francisella novicida
XWK4
AIM2
NLRP3
ASC
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.743335/full

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