Circulating miRNAs as potential marker for pulmonary hypertension.
MircoRNAs (miRNAs) are small non-coding RNAs that govern the gene expression and, play significant role in the pathogenesis of heart failure. The detection of miRNAs in circulation of pulmonary hypertensive (PH) human subjects remains elusive. In the current study, we determined the pattern of miRNA...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3662705?pdf=render |
| _version_ | 1830488281248169984 |
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| author | Chuanyu Wei Heather Henderson Christopher Spradley Li Li Il-Kwon Kim Sandeep Kumar Nayeon Hong Alejandro C Arroliga Sudhiranjan Gupta |
| author_facet | Chuanyu Wei Heather Henderson Christopher Spradley Li Li Il-Kwon Kim Sandeep Kumar Nayeon Hong Alejandro C Arroliga Sudhiranjan Gupta |
| author_sort | Chuanyu Wei |
| collection | DOAJ |
| description | MircoRNAs (miRNAs) are small non-coding RNAs that govern the gene expression and, play significant role in the pathogenesis of heart failure. The detection of miRNAs in circulation of pulmonary hypertensive (PH) human subjects remains elusive. In the current study, we determined the pattern of miRNAs of mild-to-severe human PH subjects and, compared them with the control subjects by miRNA array. Blood was obtained using fluoroscopic and waveform guided catheterization from the distal (pulmonary artery) port of the catheter. A total 40 human subjects were included in the study and, the degree of PH was determined by mean pulmonary arterial pressure. Among several miRNAs in the array, we validated 14 miRNAs and, the data were consistent with the array profile. We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects. Our study showed novel set of miRNAs which are dysregulated in PH and, are directly proportional to the degree of PH. These miRNAs may be considered as potential biomarker for early detection of PH. |
| first_indexed | 2024-12-21T19:16:16Z |
| format | Article |
| id | doaj.art-25fa49bbd7c34c7886d9f2bcfafa538c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T19:16:16Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-25fa49bbd7c34c7886d9f2bcfafa538c2022-12-21T18:53:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0185e6439610.1371/journal.pone.0064396Circulating miRNAs as potential marker for pulmonary hypertension.Chuanyu WeiHeather HendersonChristopher SpradleyLi LiIl-Kwon KimSandeep KumarNayeon HongAlejandro C ArroligaSudhiranjan GuptaMircoRNAs (miRNAs) are small non-coding RNAs that govern the gene expression and, play significant role in the pathogenesis of heart failure. The detection of miRNAs in circulation of pulmonary hypertensive (PH) human subjects remains elusive. In the current study, we determined the pattern of miRNAs of mild-to-severe human PH subjects and, compared them with the control subjects by miRNA array. Blood was obtained using fluoroscopic and waveform guided catheterization from the distal (pulmonary artery) port of the catheter. A total 40 human subjects were included in the study and, the degree of PH was determined by mean pulmonary arterial pressure. Among several miRNAs in the array, we validated 14 miRNAs and, the data were consistent with the array profile. We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects. Our study showed novel set of miRNAs which are dysregulated in PH and, are directly proportional to the degree of PH. These miRNAs may be considered as potential biomarker for early detection of PH.http://europepmc.org/articles/PMC3662705?pdf=render |
| spellingShingle | Chuanyu Wei Heather Henderson Christopher Spradley Li Li Il-Kwon Kim Sandeep Kumar Nayeon Hong Alejandro C Arroliga Sudhiranjan Gupta Circulating miRNAs as potential marker for pulmonary hypertension. PLoS ONE |
| title | Circulating miRNAs as potential marker for pulmonary hypertension. |
| title_full | Circulating miRNAs as potential marker for pulmonary hypertension. |
| title_fullStr | Circulating miRNAs as potential marker for pulmonary hypertension. |
| title_full_unstemmed | Circulating miRNAs as potential marker for pulmonary hypertension. |
| title_short | Circulating miRNAs as potential marker for pulmonary hypertension. |
| title_sort | circulating mirnas as potential marker for pulmonary hypertension |
| url | http://europepmc.org/articles/PMC3662705?pdf=render |
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