Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels
Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can activate numerous downstream effector protein...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00727/full |
| _version_ | 1819057296873881600 |
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| author | Jennifer van der Horst Iain A. Greenwood Thomas A. Jepps |
| author_facet | Jennifer van der Horst Iain A. Greenwood Thomas A. Jepps |
| author_sort | Jennifer van der Horst |
| collection | DOAJ |
| description | Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can activate numerous downstream effector proteins, generating downstream signaling pathways that regulate many functions in cells. A role for cAMP in ion channel regulation has been established, and recent findings show that cAMP signaling plays a role in Kv7 channel regulation. Although cAMP signaling is recognized to regulate Kv7 channels, the precise molecular mechanism behind the cAMP-dependent regulation of Kv7 channels is complex. This review will summarize recent research findings that support the mechanisms of cAMP-dependent regulation of Kv7 channels. |
| first_indexed | 2024-12-21T13:37:04Z |
| format | Article |
| id | doaj.art-25fc4a19a10849de98ea3d5f64d9af65 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-21T13:37:04Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-25fc4a19a10849de98ea3d5f64d9af652022-12-21T19:02:08ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-06-011110.3389/fphys.2020.00727559456Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium ChannelsJennifer van der Horst0Iain A. Greenwood1Thomas A. Jepps2Vascular Biology Group, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, DenmarkMolecular and Clinical Sciences Institute, St. George’s University of London, London, United KingdomVascular Biology Group, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, DenmarkVoltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can activate numerous downstream effector proteins, generating downstream signaling pathways that regulate many functions in cells. A role for cAMP in ion channel regulation has been established, and recent findings show that cAMP signaling plays a role in Kv7 channel regulation. Although cAMP signaling is recognized to regulate Kv7 channels, the precise molecular mechanism behind the cAMP-dependent regulation of Kv7 channels is complex. This review will summarize recent research findings that support the mechanisms of cAMP-dependent regulation of Kv7 channels.https://www.frontiersin.org/article/10.3389/fphys.2020.00727/fullKv7 (KCNQ)cAMPPKAEPACphysiology |
| spellingShingle | Jennifer van der Horst Iain A. Greenwood Thomas A. Jepps Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels Frontiers in Physiology Kv7 (KCNQ) cAMP PKA EPAC physiology |
| title | Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels |
| title_full | Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels |
| title_fullStr | Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels |
| title_full_unstemmed | Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels |
| title_short | Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels |
| title_sort | cyclic amp dependent regulation of kv7 voltage gated potassium channels |
| topic | Kv7 (KCNQ) cAMP PKA EPAC physiology |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00727/full |
| work_keys_str_mv | AT jennifervanderhorst cyclicampdependentregulationofkv7voltagegatedpotassiumchannels AT iainagreenwood cyclicampdependentregulationofkv7voltagegatedpotassiumchannels AT thomasajepps cyclicampdependentregulationofkv7voltagegatedpotassiumchannels |