Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

Mitochondrial membrane dynamics is a cellular rheostat that relates metabolic function and organelle morphology. Using an in vitro reconstitution system, we describe a mechanism for how mitochondrial inner-membrane fusion is regulated by the ratio of two forms of Opa1. We found that the long-form of...

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Bibliographic Details
Main Authors: Yifan Ge, Xiaojun Shi, Sivakumar Boopathy, Julie McDonald, Adam W Smith, Luke H Chao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
membranes
in vitro reconstitution
fusion
mitochondria
Online Access:https://elifesciences.org/articles/50973

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