Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial
Abstract Background Postoperative cognitive dysfunction (POCD) is a common complication after cardiac surgery that influences the clinical outcomes and quality of life of patients. This study aimed to evaluate the effects of Shenmai injection (SMI) on POCD of patients who underwent cardiac valve rep...
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | BMC Anesthesiology |
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| Online Access: | http://link.springer.com/article/10.1186/s12871-018-0604-7 |
| _version_ | 1818028068685479936 |
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| author | Lei Chen Liangrong Wang Qian Zhuo Qiong Zhang Feifei Chen Liling Li Lina Lin |
| author_facet | Lei Chen Liangrong Wang Qian Zhuo Qiong Zhang Feifei Chen Liling Li Lina Lin |
| author_sort | Lei Chen |
| collection | DOAJ |
| description | Abstract Background Postoperative cognitive dysfunction (POCD) is a common complication after cardiac surgery that influences the clinical outcomes and quality of life of patients. This study aimed to evaluate the effects of Shenmai injection (SMI) on POCD of patients who underwent cardiac valve replacement under cardiopulmonary bypass (CPB). Methods This prospective, randomized, controlled trial was conducted from September 2014 to January 2017. Eighty-eight patients receiving cardiac valve replacement under CPB were randomized into the control (C) or the SMI (S) group. SMI (0.6 mL/kg) was administered intravenously from the time of anesthesia induction to the beginning of CPB. Cognitive function was assessed at 3 days before surgery and 3 days, 7 days, and 1 month after surgery using the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ) score. The serum levels of neuroglobin (Ngb), hypoxia-inducible factor-1α (HIF-1α), and neuron-specific enolase (NSE) were measured at 30 min after induction (T0), immediately after the endonasal temperature rewarmed to 36 °C (T1), and 1 h (T2), 6 h (T3), 24 h (T4), 48 h (T5), and 72 h (T6) after CPB. Results Compared with the baseline values at T0, the serum Ngb levels in group C were significantly decreased at T1–2 and then increased at T3–6, while the levels in group S were decreased at T1–2 and increased at T4–6, compared to group C (p < 0.05). The serum HIF-1α levels at T1–4 and the serum NSE levels at T1–6 were significantly increased in both groups (p < 0.05). The serum levels of Ngb at T3, HIF-1α at T1–3, and NSE at T3–4,6 were lower in group S, compared to group C (p < 0.01). The MoCA-BJ scores were decreased at 3 and 7 days after surgery in both groups, and the MoCA-BJ scores in group S were higher than those in group C at 3 and 7 days after surgery (p < 0.01). Conclusion Cognitive function is impaired postoperatively in patients who have undergone cardiac valve replacement under CPB. In addition, treatment with the traditional Chinese medicine SMI decreases the serum levels of Ngb, HIF-1α, and NSE as well as attenuates cognitive dysfunction. Trial registration This trial was registered with Clinicaltrials.gov as ChiCTR-TRC-14004373 on March 11, 2014. |
| first_indexed | 2024-12-10T04:57:55Z |
| format | Article |
| id | doaj.art-25ffa4e28bc7487bbeb45c230f297e2c |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-12-10T04:57:55Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
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| series | BMC Anesthesiology |
| spelling | doaj.art-25ffa4e28bc7487bbeb45c230f297e2c2022-12-22T02:01:28ZengBMCBMC Anesthesiology1471-22532018-10-0118111010.1186/s12871-018-0604-7Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trialLei Chen0Liangrong Wang1Qian Zhuo2Qiong Zhang3Feifei Chen4Liling Li5Lina Lin6Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou People’s HospitalDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical UniversityAbstract Background Postoperative cognitive dysfunction (POCD) is a common complication after cardiac surgery that influences the clinical outcomes and quality of life of patients. This study aimed to evaluate the effects of Shenmai injection (SMI) on POCD of patients who underwent cardiac valve replacement under cardiopulmonary bypass (CPB). Methods This prospective, randomized, controlled trial was conducted from September 2014 to January 2017. Eighty-eight patients receiving cardiac valve replacement under CPB were randomized into the control (C) or the SMI (S) group. SMI (0.6 mL/kg) was administered intravenously from the time of anesthesia induction to the beginning of CPB. Cognitive function was assessed at 3 days before surgery and 3 days, 7 days, and 1 month after surgery using the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ) score. The serum levels of neuroglobin (Ngb), hypoxia-inducible factor-1α (HIF-1α), and neuron-specific enolase (NSE) were measured at 30 min after induction (T0), immediately after the endonasal temperature rewarmed to 36 °C (T1), and 1 h (T2), 6 h (T3), 24 h (T4), 48 h (T5), and 72 h (T6) after CPB. Results Compared with the baseline values at T0, the serum Ngb levels in group C were significantly decreased at T1–2 and then increased at T3–6, while the levels in group S were decreased at T1–2 and increased at T4–6, compared to group C (p < 0.05). The serum HIF-1α levels at T1–4 and the serum NSE levels at T1–6 were significantly increased in both groups (p < 0.05). The serum levels of Ngb at T3, HIF-1α at T1–3, and NSE at T3–4,6 were lower in group S, compared to group C (p < 0.01). The MoCA-BJ scores were decreased at 3 and 7 days after surgery in both groups, and the MoCA-BJ scores in group S were higher than those in group C at 3 and 7 days after surgery (p < 0.01). Conclusion Cognitive function is impaired postoperatively in patients who have undergone cardiac valve replacement under CPB. In addition, treatment with the traditional Chinese medicine SMI decreases the serum levels of Ngb, HIF-1α, and NSE as well as attenuates cognitive dysfunction. Trial registration This trial was registered with Clinicaltrials.gov as ChiCTR-TRC-14004373 on March 11, 2014.http://link.springer.com/article/10.1186/s12871-018-0604-7Cardiopulmonary bypassCognitive dysfunctionShenmai injectionCerebral protection |
| spellingShingle | Lei Chen Liangrong Wang Qian Zhuo Qiong Zhang Feifei Chen Liling Li Lina Lin Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial BMC Anesthesiology Cardiopulmonary bypass Cognitive dysfunction Shenmai injection Cerebral protection |
| title | Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial |
| title_full | Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial |
| title_fullStr | Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial |
| title_full_unstemmed | Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial |
| title_short | Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial |
| title_sort | effect of shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients a randomized controlled trial |
| topic | Cardiopulmonary bypass Cognitive dysfunction Shenmai injection Cerebral protection |
| url | http://link.springer.com/article/10.1186/s12871-018-0604-7 |
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