Study of neutrophil-lymphocyte ratio as novel marker for diabetic nephropathy in type 2 diabetes
Introduction: Diabetic nephropathy (DN) is a microvascular complication of diabetes. DN is clinically manifested as an increase in urine albumin excretion. Total white blood cell count is a crude but sensitive indicator of inflammation and studied in many cardiac and noncardiac diseases as an inflam...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2017;volume=21;issue=3;spage=387;epage=392;aulast=Khandare |
| _version_ | 1831723665528455168 |
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| author | Sagar Ashokrao Khandare Sachin Chittawar Nitin Nahar T N Dubey Zahraan Qureshi |
| author_facet | Sagar Ashokrao Khandare Sachin Chittawar Nitin Nahar T N Dubey Zahraan Qureshi |
| author_sort | Sagar Ashokrao Khandare |
| collection | DOAJ |
| description | Introduction: Diabetic nephropathy (DN) is a microvascular complication of diabetes. DN is clinically manifested as an increase in urine albumin excretion. Total white blood cell count is a crude but sensitive indicator of inflammation and studied in many cardiac and noncardiac diseases as an inflammatory marker such as acute myocardial infarction, stroke, and heart failure. In this study, the association of neutrophil-lymphocyte ratio (NLR) with DN is studied. Patients and Methods: It is an observational cross-sectional study. Totally 115 diagnosed type 2 diabetes mellitus patients were registered in this study. NLR was calculated by analyzing differential leukocyte count in complete blood picture. Albuminuria was tested by MICRAL-II TEST strips by dipstick method. Results: Totally 115 diabetic patients were registered. About 56 patients had DN and 59 had normal urine albumin. Mean NLR for a normal group is 1.94 ± 0.65 and in DN group is 2.83 ± 0.85 which was highly significant (P < 0.001). Estimated glomerular filtration rate (P = 0.047) and serum glutamate pyruvate transaminase (P < 0.001) were also significant. Conclusion: The results of our study show that there was a significant relation between NLR and DN. Therefore, NLR may be considered as a novel surrogate marker of DN in early stages. |
| first_indexed | 2024-12-21T04:06:22Z |
| format | Article |
| id | doaj.art-2600754421834ec2ab7f785ada04c4c0 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-12-21T04:06:22Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-2600754421834ec2ab7f785ada04c4c02022-12-21T19:16:34ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102017-01-0121338739210.4103/ijem.IJEM_476_16Study of neutrophil-lymphocyte ratio as novel marker for diabetic nephropathy in type 2 diabetesSagar Ashokrao KhandareSachin ChittawarNitin NaharT N DubeyZahraan QureshiIntroduction: Diabetic nephropathy (DN) is a microvascular complication of diabetes. DN is clinically manifested as an increase in urine albumin excretion. Total white blood cell count is a crude but sensitive indicator of inflammation and studied in many cardiac and noncardiac diseases as an inflammatory marker such as acute myocardial infarction, stroke, and heart failure. In this study, the association of neutrophil-lymphocyte ratio (NLR) with DN is studied. Patients and Methods: It is an observational cross-sectional study. Totally 115 diagnosed type 2 diabetes mellitus patients were registered in this study. NLR was calculated by analyzing differential leukocyte count in complete blood picture. Albuminuria was tested by MICRAL-II TEST strips by dipstick method. Results: Totally 115 diabetic patients were registered. About 56 patients had DN and 59 had normal urine albumin. Mean NLR for a normal group is 1.94 ± 0.65 and in DN group is 2.83 ± 0.85 which was highly significant (P < 0.001). Estimated glomerular filtration rate (P = 0.047) and serum glutamate pyruvate transaminase (P < 0.001) were also significant. Conclusion: The results of our study show that there was a significant relation between NLR and DN. Therefore, NLR may be considered as a novel surrogate marker of DN in early stages.http://www.ijem.in/article.asp?issn=2230-8210;year=2017;volume=21;issue=3;spage=387;epage=392;aulast=KhandareDiabetic nephropathyinflammationmicrovascularneutrophil-lymphocyte ratiourine albumin |
| spellingShingle | Sagar Ashokrao Khandare Sachin Chittawar Nitin Nahar T N Dubey Zahraan Qureshi Study of neutrophil-lymphocyte ratio as novel marker for diabetic nephropathy in type 2 diabetes Indian Journal of Endocrinology and Metabolism Diabetic nephropathy inflammation microvascular neutrophil-lymphocyte ratio urine albumin |
| title | Study of neutrophil-lymphocyte ratio as novel marker for diabetic nephropathy in type 2 diabetes |
| title_full | Study of neutrophil-lymphocyte ratio as novel marker for diabetic nephropathy in type 2 diabetes |
| title_fullStr | Study of neutrophil-lymphocyte ratio as novel marker for diabetic nephropathy in type 2 diabetes |
| title_full_unstemmed | Study of neutrophil-lymphocyte ratio as novel marker for diabetic nephropathy in type 2 diabetes |
| title_short | Study of neutrophil-lymphocyte ratio as novel marker for diabetic nephropathy in type 2 diabetes |
| title_sort | study of neutrophil lymphocyte ratio as novel marker for diabetic nephropathy in type 2 diabetes |
| topic | Diabetic nephropathy inflammation microvascular neutrophil-lymphocyte ratio urine albumin |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2017;volume=21;issue=3;spage=387;epage=392;aulast=Khandare |
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