A human ACTH-secreting corticotroph tumoroid model

A human ACTH-secreting corticotroph tumoroid model

Background: Cushing disease (CD), although rare, is a life-threatening disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma, which leads to excess adrenal-derived cortisol. Efficacious and safe medical therapies that control both hormonal hypersecretion and pituitary...

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Bibliographic Details
Main Authors: Dongyun Zhang, Willy Hugo, Peter Redublo, Hui Miao, Marvin Bergsneider, Marilene B. Wang, Won Kim, William H. Yong, Anthony P. Heaney
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:EBioMedicine
Subjects:
Adrenocorticotropic hormone (ACTH)
Cushing disease (CD)
3D culture
Proopiomelanocortin (POMC)
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421000876

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