Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1,2,3]triazole hybrids
A series of novel (isopropylidene) uridine-[1,2,3]triazole hybrids (3a–3n) were efficiently synthesized via the copper-catalyzed azide–alkyne cycloaddition (CuAAC) from N-propargyl 2′,3′-O-(isopropylidene) uridine with different aryl azides. All the synthesized compounds were screened for their in v...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-11-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610315001428 |
| _version_ | 1811232298745462784 |
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| author | Ranjith kumar Thatipamula Sirassu Narsimha Kumaraswamy Battula V. Rajendra Chary Estari Mamidala Nagavelli Vasudeva Reddy |
| author_facet | Ranjith kumar Thatipamula Sirassu Narsimha Kumaraswamy Battula V. Rajendra Chary Estari Mamidala Nagavelli Vasudeva Reddy |
| author_sort | Ranjith kumar Thatipamula |
| collection | DOAJ |
| description | A series of novel (isopropylidene) uridine-[1,2,3]triazole hybrids (3a–3n) were efficiently synthesized via the copper-catalyzed azide–alkyne cycloaddition (CuAAC) from N-propargyl 2′,3′-O-(isopropylidene) uridine with different aryl azides. All the synthesized compounds were screened for their in vitro anticancer and antibacterial activities. The anticancer activity results revealed that compounds 3d and 3f have registered equipotent activity against MCF-7 and 3n has shown excellent activity against HeLa in comparison with the standard drug Cisplatin. Remaining compounds have shown moderate to good anticancer activity against MCF-7 and HeLa cell lines. The antibacterial activity screening results revealed that, compounds 3b and 3n have shown excellent inhibition against Escherichia coli and Bacillus subtilis, 3d against Proteus vulgaris, 3k against Staphylococcus aureus and 3l against S. aureus and B. subtilis have shown equipotent activity in comparison with the standard drug Streptomycin. |
| first_indexed | 2024-04-12T11:00:55Z |
| format | Article |
| id | doaj.art-2601eda0c4c24332b552d0ad5be2d552 |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-04-12T11:00:55Z |
| publishDate | 2017-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-2601eda0c4c24332b552d0ad5be2d5522022-12-22T03:35:57ZengElsevierJournal of Saudi Chemical Society1319-61032017-11-0121779580210.1016/j.jscs.2015.12.001Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1,2,3]triazole hybridsRanjith kumar Thatipamula0Sirassu Narsimha1Kumaraswamy Battula2V. Rajendra Chary3Estari Mamidala4Nagavelli Vasudeva Reddy5Department of Chemistry, Kakatiya University, Warangal 506009, Telangana State, IndiaDepartment of Chemistry, Kakatiya University, Warangal 506009, Telangana State, IndiaDepartment of Chemistry, Kakatiya University, Warangal 506009, Telangana State, IndiaInfectious Diseases & Metabolic Disorders Research Lab, Department of Zoology, Warangal 506 009, Telangana State, IndiaInfectious Diseases & Metabolic Disorders Research Lab, Department of Zoology, Warangal 506 009, Telangana State, IndiaDepartment of Chemistry, Kakatiya University, Warangal 506009, Telangana State, IndiaA series of novel (isopropylidene) uridine-[1,2,3]triazole hybrids (3a–3n) were efficiently synthesized via the copper-catalyzed azide–alkyne cycloaddition (CuAAC) from N-propargyl 2′,3′-O-(isopropylidene) uridine with different aryl azides. All the synthesized compounds were screened for their in vitro anticancer and antibacterial activities. The anticancer activity results revealed that compounds 3d and 3f have registered equipotent activity against MCF-7 and 3n has shown excellent activity against HeLa in comparison with the standard drug Cisplatin. Remaining compounds have shown moderate to good anticancer activity against MCF-7 and HeLa cell lines. The antibacterial activity screening results revealed that, compounds 3b and 3n have shown excellent inhibition against Escherichia coli and Bacillus subtilis, 3d against Proteus vulgaris, 3k against Staphylococcus aureus and 3l against S. aureus and B. subtilis have shown equipotent activity in comparison with the standard drug Streptomycin.http://www.sciencedirect.com/science/article/pii/S1319610315001428Uridine1,2,3-TriazoleAnticancerAntibacterial activity |
| spellingShingle | Ranjith kumar Thatipamula Sirassu Narsimha Kumaraswamy Battula V. Rajendra Chary Estari Mamidala Nagavelli Vasudeva Reddy Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1,2,3]triazole hybrids Journal of Saudi Chemical Society Uridine 1,2,3-Triazole Anticancer Antibacterial activity |
| title | Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1,2,3]triazole hybrids |
| title_full | Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1,2,3]triazole hybrids |
| title_fullStr | Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1,2,3]triazole hybrids |
| title_full_unstemmed | Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1,2,3]triazole hybrids |
| title_short | Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1,2,3]triazole hybrids |
| title_sort | synthesis anticancer and antibacterial evaluation of novel isopropylidene uridine 1 2 3 triazole hybrids |
| topic | Uridine 1,2,3-Triazole Anticancer Antibacterial activity |
| url | http://www.sciencedirect.com/science/article/pii/S1319610315001428 |
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