Experimental comparative study of the histotoxicity of poly(lactic-co-glycolic acid) copolymer and poly(lactic-co-glycolic acid)-poly(isoprene) blend
Current treatments of craniosynostosis rely on the application of metal springs for cranial bone deviation. However, those metal springs demand a second surgical procedure for their removal. An attractive alternative would be the substitution of metal for bioresorbable polymers in the composition of...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Polímeros
2014-10-01
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| Series: | Polímeros |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282014000500002&lng=en&tlng=en |
| _version_ | 1819112852345061376 |
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| author | Jung Ho Kim Douglas Ramos Marques Gustavo Juliani Faller Marcus Vinícius Collares Rubens Rodriguez Luis Alberto dos Santos Diego da Silva Dias |
| author_facet | Jung Ho Kim Douglas Ramos Marques Gustavo Juliani Faller Marcus Vinícius Collares Rubens Rodriguez Luis Alberto dos Santos Diego da Silva Dias |
| author_sort | Jung Ho Kim |
| collection | DOAJ |
| description | Current treatments of craniosynostosis rely on the application of metal springs for cranial bone deviation. However, those metal springs demand a second surgical procedure for their removal. An attractive alternative would be the substitution of metal for bioresorbable polymers in the composition of the springs. The addition of poly(isoprene), PI, to poly(lactic-co-glycolic acid), PLGA, produces a polymeric blend with partial miscibility and distinct mechanical behavior that may benefit the patient recover. It is necessary to compare the histotoxicity of PLGA/PI to that presented by PLGA. In order to verify the histological behavior of the blend, 46 male Wistar rats (Rattus norvegicus, albino strain) underwent implantation of PLGA or PLGA/PI in the skull and were allocated into subgroups by timing of euthanasia (15, 30, 60, or 90 days). After euthanasia, the skull was removed and the histotoxicity was assessed histopathologically. The PLGA/PI blend showed greater histotoxicity in animals euthanized at 60 days, although in this period the histotoxicity of the PLGA/PI blend was similar to that of the PLGA copolymer at 15 days. Despite the instability of histological response, presented in different periods of observation, the results obtained in long-term show that the material has high potential for studies in craniosynostosis treatment. |
| first_indexed | 2024-12-22T04:20:05Z |
| format | Article |
| id | doaj.art-2601fc16608c456485aca8bef9632aa9 |
| institution | Directory Open Access Journal |
| issn | 1678-5169 |
| language | English |
| last_indexed | 2024-12-22T04:20:05Z |
| publishDate | 2014-10-01 |
| publisher | Associação Brasileira de Polímeros |
| record_format | Article |
| series | Polímeros |
| spelling | doaj.art-2601fc16608c456485aca8bef9632aa92022-12-21T18:39:17ZengAssociação Brasileira de PolímerosPolímeros1678-51692014-10-0124552953510.1590/0104-1428.1490S0104-14282014000500002Experimental comparative study of the histotoxicity of poly(lactic-co-glycolic acid) copolymer and poly(lactic-co-glycolic acid)-poly(isoprene) blendJung Ho Kim0Douglas Ramos Marques1Gustavo Juliani Faller2Marcus Vinícius Collares3Rubens Rodriguez4Luis Alberto dos Santos5Diego da Silva Dias6Universidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulInstituto de Patologia de Passo FundoUniversidade Federal do Rio Grande do SulInstituto de Patologia de Passo FundoUniversidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulCurrent treatments of craniosynostosis rely on the application of metal springs for cranial bone deviation. However, those metal springs demand a second surgical procedure for their removal. An attractive alternative would be the substitution of metal for bioresorbable polymers in the composition of the springs. The addition of poly(isoprene), PI, to poly(lactic-co-glycolic acid), PLGA, produces a polymeric blend with partial miscibility and distinct mechanical behavior that may benefit the patient recover. It is necessary to compare the histotoxicity of PLGA/PI to that presented by PLGA. In order to verify the histological behavior of the blend, 46 male Wistar rats (Rattus norvegicus, albino strain) underwent implantation of PLGA or PLGA/PI in the skull and were allocated into subgroups by timing of euthanasia (15, 30, 60, or 90 days). After euthanasia, the skull was removed and the histotoxicity was assessed histopathologically. The PLGA/PI blend showed greater histotoxicity in animals euthanized at 60 days, although in this period the histotoxicity of the PLGA/PI blend was similar to that of the PLGA copolymer at 15 days. Despite the instability of histological response, presented in different periods of observation, the results obtained in long-term show that the material has high potential for studies in craniosynostosis treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282014000500002&lng=en&tlng=enPLGAPIhistotoxicityin vivo |
| spellingShingle | Jung Ho Kim Douglas Ramos Marques Gustavo Juliani Faller Marcus Vinícius Collares Rubens Rodriguez Luis Alberto dos Santos Diego da Silva Dias Experimental comparative study of the histotoxicity of poly(lactic-co-glycolic acid) copolymer and poly(lactic-co-glycolic acid)-poly(isoprene) blend Polímeros PLGA PI histotoxicity in vivo |
| title | Experimental comparative study of the histotoxicity of poly(lactic-co-glycolic acid) copolymer and poly(lactic-co-glycolic acid)-poly(isoprene) blend |
| title_full | Experimental comparative study of the histotoxicity of poly(lactic-co-glycolic acid) copolymer and poly(lactic-co-glycolic acid)-poly(isoprene) blend |
| title_fullStr | Experimental comparative study of the histotoxicity of poly(lactic-co-glycolic acid) copolymer and poly(lactic-co-glycolic acid)-poly(isoprene) blend |
| title_full_unstemmed | Experimental comparative study of the histotoxicity of poly(lactic-co-glycolic acid) copolymer and poly(lactic-co-glycolic acid)-poly(isoprene) blend |
| title_short | Experimental comparative study of the histotoxicity of poly(lactic-co-glycolic acid) copolymer and poly(lactic-co-glycolic acid)-poly(isoprene) blend |
| title_sort | experimental comparative study of the histotoxicity of poly lactic co glycolic acid copolymer and poly lactic co glycolic acid poly isoprene blend |
| topic | PLGA PI histotoxicity in vivo |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282014000500002&lng=en&tlng=en |
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