VRK3 depletion induces cell cycle arrest and metabolic reprogramming of pontine diffuse midline glioma - H3K27 altered cells

VRK3 depletion induces cell cycle arrest and metabolic reprogramming of pontine diffuse midline glioma - H3K27 altered cells

We previously identified VRK3 as a specific vulnerability in DMG-H3K27M cells in a synthetic lethality screen targeting the whole kinome. The aim of the present study was to elucidate the mechanisms by which VRK3 depletion impact DMG-H3K27M cell fitness. Gene expression studies after VRK3 knockdown...

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Bibliographic Details
Main Authors: Virginie Menez, Thomas Kergrohen, Tal Shasha, Claudia Silva-Evangelista, Ludivine Le Dret, Lucie Auffret, Chloé Subecz, Manon Lancien, Yassine Ajlil, Irma Segoviano Vilchis, Kévin Beccaria, Thomas Blauwblomme, Estelle Oberlin, Jacques Grill, David Castel, Marie-Anne Debily
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Oncology
Subjects:
VRK3
diffuse midline glioma H3 K27-altered
oxidative phosphorylation (OXPHOS)
cell cycle arrest
pediatric glioma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1229312/full

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