Suppressor Mutations in LptF Bypass Essentiality of LptC by Forming a Six-Protein Transenvelope Bridge That Efficiently Transports Lipopolysaccharide

Suppressor Mutations in LptF Bypass Essentiality of LptC by Forming a Six-Protein Transenvelope Bridge That Efficiently Transports Lipopolysaccharide

ABSTRACT Lipopolysaccharide (LPS) is an essential component of the outer membrane (OM) of many Gram-negative bacteria, providing a barrier against the entry of toxic molecules. In Escherichia coli, LPS is exported to the cell surface by seven essential proteins (LptA-G) that form a transenvelope com...

Full description

Bibliographic Details
Main Authors: Federica A. Falchi, Rebecca J. Taylor, Sebastian J. Rowe, Elisabete C. C. M. Moura, Tiago Baeta, Cedric Laguri, Jean-Pierre Simorre, Daniel E. Kahne, Alessandra Polissi, Paola Sperandeo
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mBio
Subjects:
ABC transporter
ATPase
lipopolysaccharide transport
cell envelope
outer membrane biogenesis
proteoliposomes
Online Access:https://journals.asm.org/doi/10.1128/mbio.02202-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02202-22

Similar Items