Sarcopenia increases the risk for mortality in patients who undergo amputation for diabetic foot
Abstract Background Although there have been reports that diabetes affects the prevalence of sarcopenia, no studies have examined the relationship between sarcopenia and mortality in patients undergoing leg amputation. The purpose of this study is to determine whether sarcopenia affects the mortalit...
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Journal of Foot and Ankle Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13047-018-0274-1 |
| _version_ | 1797330743918067712 |
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| author | You Keun Kim Ho Seong Lee Jae Jung Ryu Hye In Lee Sang Gyo Seo |
| author_facet | You Keun Kim Ho Seong Lee Jae Jung Ryu Hye In Lee Sang Gyo Seo |
| author_sort | You Keun Kim |
| collection | DOAJ |
| description | Abstract Background Although there have been reports that diabetes affects the prevalence of sarcopenia, no studies have examined the relationship between sarcopenia and mortality in patients undergoing leg amputation. The purpose of this study is to determine whether sarcopenia affects the mortality rate of patients undergoing diabetic foot amputation. Methods From among patients who underwent limb amputation for diabetes complications, this study included 167 patients who underwent abdominal CT within 1 year of amputation. We defined sarcopenia using sex-specific cut-off points for the L3 skeletal muscle index. The 5-year survival rate was analyzed. All patients were divided into two groups and compared according to the presence of sarcopenia. The mortality rate according to sarcopenia was assessed via the Kaplan-Meier method and log-rank test. Uni- and multivariate Cox regression analyses evaluated factors associated with survival rate. Results Among the total of 167 patients, the overall 5-year mortality rate was 52.7%. Of the 112 patients with sarcopenia, the 5-year mortality rate was 60.7%. Of the 55 patients without sarcopenia, the 5-year mortality rate was 36.4%. Kaplan-Meier analysis showed a high mortality of the sarcopenia group in the univariate (p = 0.016) and multivariate (p = 0.047) analysis. Conclusions Our study is the first to analyze the relationship between diabetic amputation and sarcopenia. Sarcopenia increases the risk of mortality in patients who undergo amputation for diabetic foot. Therefore, patients with diabetes should be careful to prevent sarcopenia with enough regular exercise as well as prevent diabetic foot disease. |
| first_indexed | 2024-03-08T07:24:56Z |
| format | Article |
| id | doaj.art-26051b1c340e4e86bfbd7b85b04829af |
| institution | Directory Open Access Journal |
| issn | 1757-1146 |
| language | English |
| last_indexed | 2024-03-08T07:24:56Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Foot and Ankle Research |
| spelling | doaj.art-26051b1c340e4e86bfbd7b85b04829af2024-02-02T22:07:00ZengBMCJournal of Foot and Ankle Research1757-11462018-06-011111810.1186/s13047-018-0274-1Sarcopenia increases the risk for mortality in patients who undergo amputation for diabetic footYou Keun Kim0Ho Seong Lee1Jae Jung Ryu2Hye In Lee3Sang Gyo Seo4Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of MedicineDepartment of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of MedicineDepartment of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of MedicineDepartment of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of MedicineDepartment of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of MedicineAbstract Background Although there have been reports that diabetes affects the prevalence of sarcopenia, no studies have examined the relationship between sarcopenia and mortality in patients undergoing leg amputation. The purpose of this study is to determine whether sarcopenia affects the mortality rate of patients undergoing diabetic foot amputation. Methods From among patients who underwent limb amputation for diabetes complications, this study included 167 patients who underwent abdominal CT within 1 year of amputation. We defined sarcopenia using sex-specific cut-off points for the L3 skeletal muscle index. The 5-year survival rate was analyzed. All patients were divided into two groups and compared according to the presence of sarcopenia. The mortality rate according to sarcopenia was assessed via the Kaplan-Meier method and log-rank test. Uni- and multivariate Cox regression analyses evaluated factors associated with survival rate. Results Among the total of 167 patients, the overall 5-year mortality rate was 52.7%. Of the 112 patients with sarcopenia, the 5-year mortality rate was 60.7%. Of the 55 patients without sarcopenia, the 5-year mortality rate was 36.4%. Kaplan-Meier analysis showed a high mortality of the sarcopenia group in the univariate (p = 0.016) and multivariate (p = 0.047) analysis. Conclusions Our study is the first to analyze the relationship between diabetic amputation and sarcopenia. Sarcopenia increases the risk of mortality in patients who undergo amputation for diabetic foot. Therefore, patients with diabetes should be careful to prevent sarcopenia with enough regular exercise as well as prevent diabetic foot disease.http://link.springer.com/article/10.1186/s13047-018-0274-1SarcopeniaDiabetic footMuscleAmputationDiabetes |
| spellingShingle | You Keun Kim Ho Seong Lee Jae Jung Ryu Hye In Lee Sang Gyo Seo Sarcopenia increases the risk for mortality in patients who undergo amputation for diabetic foot Journal of Foot and Ankle Research Sarcopenia Diabetic foot Muscle Amputation Diabetes |
| title | Sarcopenia increases the risk for mortality in patients who undergo amputation for diabetic foot |
| title_full | Sarcopenia increases the risk for mortality in patients who undergo amputation for diabetic foot |
| title_fullStr | Sarcopenia increases the risk for mortality in patients who undergo amputation for diabetic foot |
| title_full_unstemmed | Sarcopenia increases the risk for mortality in patients who undergo amputation for diabetic foot |
| title_short | Sarcopenia increases the risk for mortality in patients who undergo amputation for diabetic foot |
| title_sort | sarcopenia increases the risk for mortality in patients who undergo amputation for diabetic foot |
| topic | Sarcopenia Diabetic foot Muscle Amputation Diabetes |
| url | http://link.springer.com/article/10.1186/s13047-018-0274-1 |
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