A comparative study of etomidate and propofol as induction agent for intubation in patients coming to emergency medicine department
Background & Aims: An ideal induction agent for intubation in the emergency department should have hemodynamic stability, minimal respiratory side effects and rapid clearance. Etomidate and Propofol are popular rapid-acting inducing agents; our aim is to compare hemodynamic changes and adverse e...
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| Format: | Article |
| Language: | English |
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B.J.Medical College Development Society, Ahmedabad
2023-12-01
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| Series: | BJ Kines: National Journal of Basic & Applied Sciences |
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| Online Access: | https://bjkines.com/vol15(2)Dec2023/paper17d23.pdf |
| _version_ | 1797349284230725632 |
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| author | Dr. Mittal A. Meghraj Dr. Jigarkumar B. Gosai Dr. Chirag J Patel Dr. Arunjith G Dr. Himanshu Dhanrajbhai Ramchandani Dr Pathan Uzma parvin |
| author_facet | Dr. Mittal A. Meghraj Dr. Jigarkumar B. Gosai Dr. Chirag J Patel Dr. Arunjith G Dr. Himanshu Dhanrajbhai Ramchandani Dr Pathan Uzma parvin |
| author_sort | Dr. Mittal A. Meghraj |
| collection | DOAJ |
| description | Background & Aims: An ideal induction agent for intubation in the emergency department should have hemodynamic stability, minimal respiratory side effects and rapid clearance. Etomidate and Propofol are popular rapid-acting inducing agents; our aim is to compare hemodynamic changes and adverse effects occurring between them when used as induction agents in the emergency department. Material and Methods: A study sample of 200 patients who required intubation in the emergency department were enrolled after satisfying the inclusion and exclusion criteria and were divided into two equal groups. After
assessing the primary survey of airway, baseline hemodynamic parameters, Group A was given Inj. Etomidate 0.3–0.5 mg/kg iv and Group B was given Inj. Propofol 0.5–1.5 mg/kg iv as an induction agent, followed by that Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), respiratory rate (RR), oxygen saturation, myoclonus, nausea, and vomiting were monitored after induction and intubation at one, five and fifteen minutes. Result: The mean changes in HR, SBP, DBP, and MAP of groups A and B were compared, there was significant reduction in all three parameters in Propofol compared to Etomidate. In group A, out of 100 patients, 25 had myoclonus, 15 had vomiting, and no side effect was observed in the other 60 patients. In group B, out of 100 patients, 22 had apnea,14 had vomiting, and no side effect was observed in the remaining 64 patients. Conclusion: This study concludes that Etomidate is a better agent for induction than Propofol in view of hemodynamic stability. The incidence of apnea was higher with Propofol, and myoclonus more with Etomidate. |
| first_indexed | 2024-03-08T12:28:04Z |
| format | Article |
| id | doaj.art-26060ed7bb96417c90af1321c919f503 |
| institution | Directory Open Access Journal |
| issn | 2231-6140 2395-7859 |
| language | English |
| last_indexed | 2024-03-08T12:28:04Z |
| publishDate | 2023-12-01 |
| publisher | B.J.Medical College Development Society, Ahmedabad |
| record_format | Article |
| series | BJ Kines: National Journal of Basic & Applied Sciences |
| spelling | doaj.art-26060ed7bb96417c90af1321c919f5032024-01-22T06:23:02ZengB.J.Medical College Development Society, AhmedabadBJ Kines: National Journal of Basic & Applied Sciences2231-61402395-78592023-12-0115211011410.56018/20231217A comparative study of etomidate and propofol as induction agent for intubation in patients coming to emergency medicine departmentDr. Mittal A. Meghraj0Dr. Jigarkumar B. Gosai1Dr. Chirag J Patel2Dr. Arunjith G3Dr. Himanshu Dhanrajbhai Ramchandani4Dr Pathan Uzma parvin5Parul University, Vadodara, Gujarat, India.B.J Medical College, AhmedabadB.J Medical College, AhmedabadB.J Medical College, AhmedabadB.J Medical College, AhmedabadB.J Medical College, AhmedabadBackground & Aims: An ideal induction agent for intubation in the emergency department should have hemodynamic stability, minimal respiratory side effects and rapid clearance. Etomidate and Propofol are popular rapid-acting inducing agents; our aim is to compare hemodynamic changes and adverse effects occurring between them when used as induction agents in the emergency department. Material and Methods: A study sample of 200 patients who required intubation in the emergency department were enrolled after satisfying the inclusion and exclusion criteria and were divided into two equal groups. After assessing the primary survey of airway, baseline hemodynamic parameters, Group A was given Inj. Etomidate 0.3–0.5 mg/kg iv and Group B was given Inj. Propofol 0.5–1.5 mg/kg iv as an induction agent, followed by that Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), respiratory rate (RR), oxygen saturation, myoclonus, nausea, and vomiting were monitored after induction and intubation at one, five and fifteen minutes. Result: The mean changes in HR, SBP, DBP, and MAP of groups A and B were compared, there was significant reduction in all three parameters in Propofol compared to Etomidate. In group A, out of 100 patients, 25 had myoclonus, 15 had vomiting, and no side effect was observed in the other 60 patients. In group B, out of 100 patients, 22 had apnea,14 had vomiting, and no side effect was observed in the remaining 64 patients. Conclusion: This study concludes that Etomidate is a better agent for induction than Propofol in view of hemodynamic stability. The incidence of apnea was higher with Propofol, and myoclonus more with Etomidate. https://bjkines.com/vol15(2)Dec2023/paper17d23.pdfetomidatepropofolintubation |
| spellingShingle | Dr. Mittal A. Meghraj Dr. Jigarkumar B. Gosai Dr. Chirag J Patel Dr. Arunjith G Dr. Himanshu Dhanrajbhai Ramchandani Dr Pathan Uzma parvin A comparative study of etomidate and propofol as induction agent for intubation in patients coming to emergency medicine department BJ Kines: National Journal of Basic & Applied Sciences etomidate propofol intubation |
| title | A comparative study of etomidate and propofol as induction agent for intubation in patients coming to emergency medicine department |
| title_full | A comparative study of etomidate and propofol as induction agent for intubation in patients coming to emergency medicine department |
| title_fullStr | A comparative study of etomidate and propofol as induction agent for intubation in patients coming to emergency medicine department |
| title_full_unstemmed | A comparative study of etomidate and propofol as induction agent for intubation in patients coming to emergency medicine department |
| title_short | A comparative study of etomidate and propofol as induction agent for intubation in patients coming to emergency medicine department |
| title_sort | comparative study of etomidate and propofol as induction agent for intubation in patients coming to emergency medicine department |
| topic | etomidate propofol intubation |
| url | https://bjkines.com/vol15(2)Dec2023/paper17d23.pdf |
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