Hepatitis E virus infection is highly prevalent among pregnant women in Accra, Ghana
<p>Abstract</p> <p>Background</p> <p>Hepatitis E virus (HEV) is highly endemic in several African countries with high mortality rate among pregnant women. The prevalence of antibodies to HEV in Ghana is not known. Therefore we evaluated the prevalence of anti-HEV IgG an...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-07-01
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| Series: | Virology Journal |
| Online Access: | http://www.virologyj.com/content/6/1/108 |
| _version_ | 1818556452917215232 |
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| author | Mingle Julius AA Obed Samuel Adu-Gyamfi Clement Aviyase John T Tettey Yao Adjei Andrew A Ayeh-Kumi Patrick F Adiku Theophilus K |
| author_facet | Mingle Julius AA Obed Samuel Adu-Gyamfi Clement Aviyase John T Tettey Yao Adjei Andrew A Ayeh-Kumi Patrick F Adiku Theophilus K |
| author_sort | Mingle Julius AA |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Hepatitis E virus (HEV) is highly endemic in several African countries with high mortality rate among pregnant women. The prevalence of antibodies to HEV in Ghana is not known. Therefore we evaluated the prevalence of anti-HEV IgG and anti-HEV IgM among pregnant women seen between the months of January and May, 2008 at the Obstetrics and Gynaecology Department, Korle-Bu Teaching Hospital, Accra, Ghana.</p> <p>Results</p> <p>One hundred and fifty-seven women provided blood samples for unlinked anonymous testing for the presence of antibodies to HEV. The median age of participants was 28.89 ± 5.76 years (range 13–42 years). Of the 157 women tested, HEV seroprevelance was 28.66% (45/157). Among the seropositive women, 64.40% (29/45) tested positive for anti-HEV IgM while 35.60% (16/45) tested positive to HEV IgG antibodies. HEV seroprevalence was highest (46.15%) among women 21–25 years of age, followed by 42.82% in = 20 year group, then 36.84% in = 36 year group. Of the 157 women, 75.79% and 22.92% were in their third and second trimesters of pregnancy, respectively. Anti-HEV antibodies detected in women in their third trimester of pregnancy (30.25%) was significantly higher, P < 0.05, than in women in their second trimester of pregnancy (25.0%).</p> <p>Conclusion</p> <p>Consistent with similar studies worldwide, the results of our studies revealed a high prevalence of HEV infection in pregnant women.</p> |
| first_indexed | 2024-12-13T23:47:32Z |
| format | Article |
| id | doaj.art-2606f36c901d43e1b93d60ab3c73ae1b |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-13T23:47:32Z |
| publishDate | 2009-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-2606f36c901d43e1b93d60ab3c73ae1b2022-12-21T23:26:54ZengBMCVirology Journal1743-422X2009-07-016110810.1186/1743-422X-6-108Hepatitis E virus infection is highly prevalent among pregnant women in Accra, GhanaMingle Julius AAObed SamuelAdu-Gyamfi ClementAviyase John TTettey YaoAdjei Andrew AAyeh-Kumi Patrick FAdiku Theophilus K<p>Abstract</p> <p>Background</p> <p>Hepatitis E virus (HEV) is highly endemic in several African countries with high mortality rate among pregnant women. The prevalence of antibodies to HEV in Ghana is not known. Therefore we evaluated the prevalence of anti-HEV IgG and anti-HEV IgM among pregnant women seen between the months of January and May, 2008 at the Obstetrics and Gynaecology Department, Korle-Bu Teaching Hospital, Accra, Ghana.</p> <p>Results</p> <p>One hundred and fifty-seven women provided blood samples for unlinked anonymous testing for the presence of antibodies to HEV. The median age of participants was 28.89 ± 5.76 years (range 13–42 years). Of the 157 women tested, HEV seroprevelance was 28.66% (45/157). Among the seropositive women, 64.40% (29/45) tested positive for anti-HEV IgM while 35.60% (16/45) tested positive to HEV IgG antibodies. HEV seroprevalence was highest (46.15%) among women 21–25 years of age, followed by 42.82% in = 20 year group, then 36.84% in = 36 year group. Of the 157 women, 75.79% and 22.92% were in their third and second trimesters of pregnancy, respectively. Anti-HEV antibodies detected in women in their third trimester of pregnancy (30.25%) was significantly higher, P < 0.05, than in women in their second trimester of pregnancy (25.0%).</p> <p>Conclusion</p> <p>Consistent with similar studies worldwide, the results of our studies revealed a high prevalence of HEV infection in pregnant women.</p>http://www.virologyj.com/content/6/1/108 |
| spellingShingle | Mingle Julius AA Obed Samuel Adu-Gyamfi Clement Aviyase John T Tettey Yao Adjei Andrew A Ayeh-Kumi Patrick F Adiku Theophilus K Hepatitis E virus infection is highly prevalent among pregnant women in Accra, Ghana Virology Journal |
| title | Hepatitis E virus infection is highly prevalent among pregnant women in Accra, Ghana |
| title_full | Hepatitis E virus infection is highly prevalent among pregnant women in Accra, Ghana |
| title_fullStr | Hepatitis E virus infection is highly prevalent among pregnant women in Accra, Ghana |
| title_full_unstemmed | Hepatitis E virus infection is highly prevalent among pregnant women in Accra, Ghana |
| title_short | Hepatitis E virus infection is highly prevalent among pregnant women in Accra, Ghana |
| title_sort | hepatitis e virus infection is highly prevalent among pregnant women in accra ghana |
| url | http://www.virologyj.com/content/6/1/108 |
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