The role of C-terminal tensin-like (Cten) gene in cancer metastasis
C-terminal tensin-like (cten, also known as tensin4, TNS4) is the fourth member of the tensin family. all tensin family members localizes in focal adhesion sites. Cten shares the sequence homology with other tensins at its C-terminal region by having the SH2 and PTB domains. Cten is expressed in som...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Discover STM Publishing Ltd
2018-06-01
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| Series: | Journal of Biochemical and Clinical Genetics |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=978 |
| _version_ | 1797817688200839168 |
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| author | Saleh Alghamdi Sarah Alkwai Mohammad Ilyas |
| author_facet | Saleh Alghamdi Sarah Alkwai Mohammad Ilyas |
| author_sort | Saleh Alghamdi |
| collection | DOAJ |
| description | C-terminal tensin-like (cten, also known as tensin4, TNS4) is the fourth member of the tensin family. all tensin family members localizes in focal adhesion sites. Cten shares the sequence homology with other tensins at its C-terminal region by having the SH2 and PTB domains. Cten is expressed in some normal tissue such as prostate and placenta while down-regulated in prostate cancer. The overexpression of cten was found associates with tumors of breast, colon, lung, stomach, skin and pancreas. It interacts with growth factors and cytokines as regulators. Also it has been found that cten expression promotes cell motility and enhances tumorigenicity. The collective findings support that cten is having a role in carcinogenesis and promising biomarker. It can be a candidate for a therapeutic target for solid cancers. [JBCGenetics 2018; 1(1.000): 2-9] |
| first_indexed | 2024-03-13T08:57:08Z |
| format | Article |
| id | doaj.art-2607675c6fee465294dbd5dac30c4c9f |
| institution | Directory Open Access Journal |
| issn | 1658-807X |
| language | English |
| last_indexed | 2024-03-13T08:57:08Z |
| publishDate | 2018-06-01 |
| publisher | Discover STM Publishing Ltd |
| record_format | Article |
| series | Journal of Biochemical and Clinical Genetics |
| spelling | doaj.art-2607675c6fee465294dbd5dac30c4c9f2023-05-28T13:26:19ZengDiscover STM Publishing LtdJournal of Biochemical and Clinical Genetics1658-807X2018-06-01112910.24911/JBCGenetics/183-1531548689978The role of C-terminal tensin-like (Cten) gene in cancer metastasisSaleh Alghamdi0Sarah Alkwai1Mohammad Ilyas2King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Medical Genomics Research Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Medical Genomics Research Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham Molecular Pathology Node, United KingdomC-terminal tensin-like (cten, also known as tensin4, TNS4) is the fourth member of the tensin family. all tensin family members localizes in focal adhesion sites. Cten shares the sequence homology with other tensins at its C-terminal region by having the SH2 and PTB domains. Cten is expressed in some normal tissue such as prostate and placenta while down-regulated in prostate cancer. The overexpression of cten was found associates with tumors of breast, colon, lung, stomach, skin and pancreas. It interacts with growth factors and cytokines as regulators. Also it has been found that cten expression promotes cell motility and enhances tumorigenicity. The collective findings support that cten is having a role in carcinogenesis and promising biomarker. It can be a candidate for a therapeutic target for solid cancers. [JBCGenetics 2018; 1(1.000): 2-9]http://www.ejmanager.com/fulltextpdf.php?mno=978ctencolorectal cancertensinmetastasis |
| spellingShingle | Saleh Alghamdi Sarah Alkwai Mohammad Ilyas The role of C-terminal tensin-like (Cten) gene in cancer metastasis Journal of Biochemical and Clinical Genetics cten colorectal cancer tensin metastasis |
| title | The role of C-terminal tensin-like (Cten) gene in cancer metastasis |
| title_full | The role of C-terminal tensin-like (Cten) gene in cancer metastasis |
| title_fullStr | The role of C-terminal tensin-like (Cten) gene in cancer metastasis |
| title_full_unstemmed | The role of C-terminal tensin-like (Cten) gene in cancer metastasis |
| title_short | The role of C-terminal tensin-like (Cten) gene in cancer metastasis |
| title_sort | role of c terminal tensin like cten gene in cancer metastasis |
| topic | cten colorectal cancer tensin metastasis |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=978 |
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