Nonconvulsive status epilepticus characteristics in glioma patients: a retrospective study
Abstract Purpose Epilepsy is a common complication of gliomas. The diagnosis of nonconvulsive status epilepticus (NCSE) is challenging because it causes impaired consciousness and mimics glioma progression. NCSE complication rate in the general brain tumor patient population is approximately 2%. How...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2023-03-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-023-00632-3 |
| _version_ | 1797864337107320832 |
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| author | Azumi Kaneoka Satoka Hashimoto Fujimoto Kaoru Tamura Motoki Inaji Taketoshi Maehara |
| author_facet | Azumi Kaneoka Satoka Hashimoto Fujimoto Kaoru Tamura Motoki Inaji Taketoshi Maehara |
| author_sort | Azumi Kaneoka |
| collection | DOAJ |
| description | Abstract Purpose Epilepsy is a common complication of gliomas. The diagnosis of nonconvulsive status epilepticus (NCSE) is challenging because it causes impaired consciousness and mimics glioma progression. NCSE complication rate in the general brain tumor patient population is approximately 2%. However, there are no reports focusing on NCSE in glioma patient population. This study aimed to reveal the epidemiology and features of NCSE in glioma patients to enable appropriate diagnosis. Methods We enrolled 108 consecutive glioma patients (45 female, 63 male) who underwent their first surgery between April 2013 and May 2019 at our institution. We retrospectively investigated glioma patients diagnosed with tumor-related epilepsy (TRE) or NCSE to explore disease frequency of TRE/NCSE and patient background. NCSE treatment approaches and Karnofsky Performance Status Scale (KPS) changes following NCSE were surveyed. NCSE diagnosis was confirmed using the modified Salzburg Consensus Criteria (mSCC). Results Sixty-one out of 108 glioma patients experienced TRE (56%), and five (4.6%) were diagnosed with NCSE (2 female, 3 male; mean age, 57 years old; WHO grade II 1, grade III 2, grade IV 2). All NCSE cases were controlled by stage 2 status epilepticus treatment as recommended in the Clinical Practice Guidelines for Epilepsy by the Japan Epilepsy Society. The KPS score significantly decreased after NCSE. Conclusion Higher prevalence of NCSE in glioma patients was observed. The KPS score significantly decreased after NCSE. Actively taking electroencephalograms analyzed by mSCC may facilitate accurate NCSE diagnosis and improve the activities of daily living in glioma patients. |
| first_indexed | 2024-04-09T22:50:09Z |
| format | Article |
| id | doaj.art-26078016384845f1a229122cc5c1b5b5 |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-04-09T22:50:09Z |
| publishDate | 2023-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-26078016384845f1a229122cc5c1b5b52023-03-22T11:39:23ZengSpringerDiscover Oncology2730-60112023-03-0114111110.1007/s12672-023-00632-3Nonconvulsive status epilepticus characteristics in glioma patients: a retrospective studyAzumi Kaneoka0Satoka Hashimoto Fujimoto1Kaoru Tamura2Motoki Inaji3Taketoshi Maehara4Department of Neurosurgery, Tokyo Medical and Dental UniversityDepartment of Neurosurgery, Tokyo Medical and Dental UniversityDepartment of Neurosurgery, Tokyo Medical and Dental UniversityDepartment of Neurosurgery, Tokyo Medical and Dental UniversityDepartment of Neurosurgery, Tokyo Medical and Dental UniversityAbstract Purpose Epilepsy is a common complication of gliomas. The diagnosis of nonconvulsive status epilepticus (NCSE) is challenging because it causes impaired consciousness and mimics glioma progression. NCSE complication rate in the general brain tumor patient population is approximately 2%. However, there are no reports focusing on NCSE in glioma patient population. This study aimed to reveal the epidemiology and features of NCSE in glioma patients to enable appropriate diagnosis. Methods We enrolled 108 consecutive glioma patients (45 female, 63 male) who underwent their first surgery between April 2013 and May 2019 at our institution. We retrospectively investigated glioma patients diagnosed with tumor-related epilepsy (TRE) or NCSE to explore disease frequency of TRE/NCSE and patient background. NCSE treatment approaches and Karnofsky Performance Status Scale (KPS) changes following NCSE were surveyed. NCSE diagnosis was confirmed using the modified Salzburg Consensus Criteria (mSCC). Results Sixty-one out of 108 glioma patients experienced TRE (56%), and five (4.6%) were diagnosed with NCSE (2 female, 3 male; mean age, 57 years old; WHO grade II 1, grade III 2, grade IV 2). All NCSE cases were controlled by stage 2 status epilepticus treatment as recommended in the Clinical Practice Guidelines for Epilepsy by the Japan Epilepsy Society. The KPS score significantly decreased after NCSE. Conclusion Higher prevalence of NCSE in glioma patients was observed. The KPS score significantly decreased after NCSE. Actively taking electroencephalograms analyzed by mSCC may facilitate accurate NCSE diagnosis and improve the activities of daily living in glioma patients.https://doi.org/10.1007/s12672-023-00632-3GliomaEpilepsyNonconvulsive status epilepticus (NCSE)Modified Salzburg Consensus Criteria (mSCC) |
| spellingShingle | Azumi Kaneoka Satoka Hashimoto Fujimoto Kaoru Tamura Motoki Inaji Taketoshi Maehara Nonconvulsive status epilepticus characteristics in glioma patients: a retrospective study Discover Oncology Glioma Epilepsy Nonconvulsive status epilepticus (NCSE) Modified Salzburg Consensus Criteria (mSCC) |
| title | Nonconvulsive status epilepticus characteristics in glioma patients: a retrospective study |
| title_full | Nonconvulsive status epilepticus characteristics in glioma patients: a retrospective study |
| title_fullStr | Nonconvulsive status epilepticus characteristics in glioma patients: a retrospective study |
| title_full_unstemmed | Nonconvulsive status epilepticus characteristics in glioma patients: a retrospective study |
| title_short | Nonconvulsive status epilepticus characteristics in glioma patients: a retrospective study |
| title_sort | nonconvulsive status epilepticus characteristics in glioma patients a retrospective study |
| topic | Glioma Epilepsy Nonconvulsive status epilepticus (NCSE) Modified Salzburg Consensus Criteria (mSCC) |
| url | https://doi.org/10.1007/s12672-023-00632-3 |
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