Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation
In myeloproliferative neoplasms, frameshift mutants of calreticulin turn into rogue cytokines by inducing constitutive activation of the Thrombopoietin Receptor (TpoR). Here, the authors define how mutant calreticulin acquires specificity for TpoR binding and triggers its constitutive activation.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37277-3 |
| _version_ | 1797849950829150208 |
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| author | Nicolas Papadopoulos Audrey Nédélec Allison Derenne Teodor Asvadur Şulea Christian Pecquet Ilyas Chachoua Gaëlle Vertenoeil Thomas Tilmant Andrei-Jose Petrescu Gabriel Mazzucchelli Bogdan I. Iorga Didier Vertommen Stefan N. Constantinescu |
| author_facet | Nicolas Papadopoulos Audrey Nédélec Allison Derenne Teodor Asvadur Şulea Christian Pecquet Ilyas Chachoua Gaëlle Vertenoeil Thomas Tilmant Andrei-Jose Petrescu Gabriel Mazzucchelli Bogdan I. Iorga Didier Vertommen Stefan N. Constantinescu |
| author_sort | Nicolas Papadopoulos |
| collection | DOAJ |
| description | In myeloproliferative neoplasms, frameshift mutants of calreticulin turn into rogue cytokines by inducing constitutive activation of the Thrombopoietin Receptor (TpoR). Here, the authors define how mutant calreticulin acquires specificity for TpoR binding and triggers its constitutive activation. |
| first_indexed | 2024-04-09T18:52:29Z |
| format | Article |
| id | doaj.art-2608cc9507e54cfda715fbc3e86b7d63 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T18:52:29Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2608cc9507e54cfda715fbc3e86b7d632023-04-09T11:20:56ZengNature PortfolioNature Communications2041-17232023-04-0114111610.1038/s41467-023-37277-3Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activationNicolas Papadopoulos0Audrey Nédélec1Allison Derenne2Teodor Asvadur Şulea3Christian Pecquet4Ilyas Chachoua5Gaëlle Vertenoeil6Thomas Tilmant7Andrei-Jose Petrescu8Gabriel Mazzucchelli9Bogdan I. Iorga10Didier Vertommen11Stefan N. Constantinescu12Ludwig Institute for Cancer Research BrusselsLudwig Institute for Cancer Research BrusselsSpectralys Biotech SRLDepartment of Bioinformatics and Structural Biochemistry, Institute of Biochemistry of the Romanian AcademyLudwig Institute for Cancer Research BrusselsLudwig Institute for Cancer Research BrusselsLudwig Institute for Cancer Research BrusselsMass Spectrometry Laboratory, MolSys Research Unit, Universiy of LiègeDepartment of Bioinformatics and Structural Biochemistry, Institute of Biochemistry of the Romanian AcademyMass Spectrometry Laboratory, MolSys Research Unit, Universiy of LiègeUniversité Paris-Saclay, CNRS, Institut de Chimie des Substances NaturellesUniversité catholique de Louvain and de Duve InstituteLudwig Institute for Cancer Research BrusselsIn myeloproliferative neoplasms, frameshift mutants of calreticulin turn into rogue cytokines by inducing constitutive activation of the Thrombopoietin Receptor (TpoR). Here, the authors define how mutant calreticulin acquires specificity for TpoR binding and triggers its constitutive activation.https://doi.org/10.1038/s41467-023-37277-3 |
| spellingShingle | Nicolas Papadopoulos Audrey Nédélec Allison Derenne Teodor Asvadur Şulea Christian Pecquet Ilyas Chachoua Gaëlle Vertenoeil Thomas Tilmant Andrei-Jose Petrescu Gabriel Mazzucchelli Bogdan I. Iorga Didier Vertommen Stefan N. Constantinescu Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation Nature Communications |
| title | Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation |
| title_full | Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation |
| title_fullStr | Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation |
| title_full_unstemmed | Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation |
| title_short | Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation |
| title_sort | oncogenic calr mutant c terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation |
| url | https://doi.org/10.1038/s41467-023-37277-3 |
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