A double‐blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I‐745 in formula‐fed preterm infants
Objective: The use of probiotics is increasingly popular in preterm neonates, as they may prevent necrotizing enterocolitis (NEC) sepsis and improve growth and feeding tolerance. There is only limited literature on Saccharomyces boulardii CNCM I‐745 (S. boulardii) in preterm infants. Method: A prosp...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Portuguese |
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Brazilian Society of Pediatrics
2016-05-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255553616000380 |
| _version_ | 1811249295346630656 |
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| author | Lingfen Xu Yun Wang Yang Wang Jianhua Fu Mei Sun Zhiqin Mao Yvan Vandenplas |
| author_facet | Lingfen Xu Yun Wang Yang Wang Jianhua Fu Mei Sun Zhiqin Mao Yvan Vandenplas |
| author_sort | Lingfen Xu |
| collection | DOAJ |
| description | Objective: The use of probiotics is increasingly popular in preterm neonates, as they may prevent necrotizing enterocolitis (NEC) sepsis and improve growth and feeding tolerance. There is only limited literature on Saccharomyces boulardii CNCM I‐745 (S. boulardii) in preterm infants.
Method: A prospective, randomized, case‐controlled trial with the probiotic S. boulardii (50 mg/kg twice daily) was conducted in newborns with a gestational age of 30 to 37 weeks and a birth weight between 1,500 to 2,500 g.
Results: 125 neonates were enrolled; 63 in the treatment and 62 in the control group. Weight gain (16.14 ± 1.96 vs. 10.73 ± 1.77 g/kg/day, p < 0.05) and formula intake at maximal enteral feeding (128.4 ± 6.7 vs. 112.3 ± 7.2 mL/kg/day, p < 0.05) were significantly higher in the intervention group. Once enteral feeding was started, the time needed to reach full enteral feeding was significantly shorter in the probiotic group (0.4 ± 0.1 vs. 1.7 ± 0.5 days, p < 0.05). There was no significant difference in sepsis. NEC did not occur. No adverse effects related to S. boulardii were observed.
Conclusion: Prophylactic supplementation of S. boulardii at a dose of 50 mg/kg twice a day improved weight gain, improved feeding tolerance, and had no adverse effects in preterm infants > 30 weeks old. |
| first_indexed | 2024-04-12T15:43:58Z |
| format | Article |
| id | doaj.art-2609b17dc142443db045eb9e43466c25 |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-12T15:43:58Z |
| publishDate | 2016-05-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-2609b17dc142443db045eb9e43466c252022-12-22T03:26:42ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362016-05-0192329630110.1016/j.jpedp.2016.03.004A double‐blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I‐745 in formula‐fed preterm infantsLingfen Xu0Yun Wang1Yang Wang2Jianhua Fu3Mei Sun4Zhiqin Mao5Yvan Vandenplas6Departamento de Pediatria, Shengjing Hospital, China Medical University, Shenyang, ChinaDepartamento de Pediatria, Qingdao Women and Children's Hospital, Qingdao, ChinaDepartamento de Pediatria, Shengjing Hospital, China Medical University, Shenyang, ChinaDepartamento de Pediatria, Shengjing Hospital, China Medical University, Shenyang, ChinaDepartamento de Pediatria, Shengjing Hospital, China Medical University, Shenyang, ChinaDepartamento de Pediatria, Shengjing Hospital, China Medical University, Shenyang, ChinaUZ Brussel, Departamento de Pediatria, Vrije Universiteit Brussel, Bruxelas, BélgicaObjective: The use of probiotics is increasingly popular in preterm neonates, as they may prevent necrotizing enterocolitis (NEC) sepsis and improve growth and feeding tolerance. There is only limited literature on Saccharomyces boulardii CNCM I‐745 (S. boulardii) in preterm infants. Method: A prospective, randomized, case‐controlled trial with the probiotic S. boulardii (50 mg/kg twice daily) was conducted in newborns with a gestational age of 30 to 37 weeks and a birth weight between 1,500 to 2,500 g. Results: 125 neonates were enrolled; 63 in the treatment and 62 in the control group. Weight gain (16.14 ± 1.96 vs. 10.73 ± 1.77 g/kg/day, p < 0.05) and formula intake at maximal enteral feeding (128.4 ± 6.7 vs. 112.3 ± 7.2 mL/kg/day, p < 0.05) were significantly higher in the intervention group. Once enteral feeding was started, the time needed to reach full enteral feeding was significantly shorter in the probiotic group (0.4 ± 0.1 vs. 1.7 ± 0.5 days, p < 0.05). There was no significant difference in sepsis. NEC did not occur. No adverse effects related to S. boulardii were observed. Conclusion: Prophylactic supplementation of S. boulardii at a dose of 50 mg/kg twice a day improved weight gain, improved feeding tolerance, and had no adverse effects in preterm infants > 30 weeks old.http://www.sciencedirect.com/science/article/pii/S2255553616000380Feeding (in)toleranceGrowthNecrotizing enterocolitisPreterm infantProbioticSepsis |
| spellingShingle | Lingfen Xu Yun Wang Yang Wang Jianhua Fu Mei Sun Zhiqin Mao Yvan Vandenplas A double‐blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I‐745 in formula‐fed preterm infants Jornal de Pediatria (Versão em Português) Feeding (in)tolerance Growth Necrotizing enterocolitis Preterm infant Probiotic Sepsis |
| title | A double‐blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I‐745 in formula‐fed preterm infants |
| title_full | A double‐blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I‐745 in formula‐fed preterm infants |
| title_fullStr | A double‐blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I‐745 in formula‐fed preterm infants |
| title_full_unstemmed | A double‐blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I‐745 in formula‐fed preterm infants |
| title_short | A double‐blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I‐745 in formula‐fed preterm infants |
| title_sort | double blinded randomized trial on growth and feeding tolerance with saccharomyces boulardii cncm i 745 in formula fed preterm infants |
| topic | Feeding (in)tolerance Growth Necrotizing enterocolitis Preterm infant Probiotic Sepsis |
| url | http://www.sciencedirect.com/science/article/pii/S2255553616000380 |
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