Perilla Oil, An Omega-3 Unsaturated Fatty Acid-Rich Oil, Enhances Diversity of Gut Microbiota and May Relieve Constipation in Sedentary Healthy Female: A Nonrandomized Placebo-Controlled Pilot Study
This study shows the effect of omega-3 unsaturated fatty acids via perilla oil intake on gut microbiota and constipation. Eight sedentary females participated in a nonrandomized placebo-controlled pilot study consisting of eight-week perilla oil (OIL) and placebo (PLA) intervention phases. There was...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Dietetics |
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| Online Access: | https://www.mdpi.com/2674-0311/2/2/15 |
| _version_ | 1797595238711164928 |
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| author | Aki Kawamura Masaaki Sugita |
| author_facet | Aki Kawamura Masaaki Sugita |
| author_sort | Aki Kawamura |
| collection | DOAJ |
| description | This study shows the effect of omega-3 unsaturated fatty acids via perilla oil intake on gut microbiota and constipation. Eight sedentary females participated in a nonrandomized placebo-controlled pilot study consisting of eight-week perilla oil (OIL) and placebo (PLA) intervention phases. There was a 10-month washout period between phases. All participants received 9 g of perilla oil-containing jelly in the OIL phase, and a placebo jelly in the PLA phase. Gut microbiota, α-diversity, and constipation scores were measured pre- and post-intervention in both phases. The α-diversity, an important indicator of gut microbiota diversity, was significantly increased post-intervention (4.5 ± 0.1) compared to pre-intervention (3.8 ± 0.3) in the OIL only (<i>p</i> = 0.021). Notably, the level of α-diversity was maintained even after the washout period of 10 months. Butyrate-producing bacteria, Lachnospiraceae (%), did not change in the OIL but were significantly reduced post-intervention (15.1 ± 4.8) compared to pre-intervention (20.1 ± 7.0) in the PLA (<i>p</i> = 0.040). In addition, the constipation scores were significantly or tended to be reduced during the OIL phase only (<i>p</i> < 0.05, <i>p</i> < 0.1). In conclusion, an eight-week perilla oil supplementation may enhance and establish the diversity of gut microbiota, which may relieve constipation. |
| first_indexed | 2024-03-11T02:34:26Z |
| format | Article |
| id | doaj.art-260b9f2b415344db984186b4e72a223d |
| institution | Directory Open Access Journal |
| issn | 2674-0311 |
| language | English |
| last_indexed | 2024-03-11T02:34:26Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dietetics |
| spelling | doaj.art-260b9f2b415344db984186b4e72a223d2023-11-18T10:01:33ZengMDPI AGDietetics2674-03112023-06-012219120210.3390/dietetics2020015Perilla Oil, An Omega-3 Unsaturated Fatty Acid-Rich Oil, Enhances Diversity of Gut Microbiota and May Relieve Constipation in Sedentary Healthy Female: A Nonrandomized Placebo-Controlled Pilot StudyAki Kawamura0Masaaki Sugita1Faculty of Sport Science, Nippon Sport Science University, Tokyo 1588508, JapanFaculty of Sport Science, Nippon Sport Science University, Tokyo 1588508, JapanThis study shows the effect of omega-3 unsaturated fatty acids via perilla oil intake on gut microbiota and constipation. Eight sedentary females participated in a nonrandomized placebo-controlled pilot study consisting of eight-week perilla oil (OIL) and placebo (PLA) intervention phases. There was a 10-month washout period between phases. All participants received 9 g of perilla oil-containing jelly in the OIL phase, and a placebo jelly in the PLA phase. Gut microbiota, α-diversity, and constipation scores were measured pre- and post-intervention in both phases. The α-diversity, an important indicator of gut microbiota diversity, was significantly increased post-intervention (4.5 ± 0.1) compared to pre-intervention (3.8 ± 0.3) in the OIL only (<i>p</i> = 0.021). Notably, the level of α-diversity was maintained even after the washout period of 10 months. Butyrate-producing bacteria, Lachnospiraceae (%), did not change in the OIL but were significantly reduced post-intervention (15.1 ± 4.8) compared to pre-intervention (20.1 ± 7.0) in the PLA (<i>p</i> = 0.040). In addition, the constipation scores were significantly or tended to be reduced during the OIL phase only (<i>p</i> < 0.05, <i>p</i> < 0.1). In conclusion, an eight-week perilla oil supplementation may enhance and establish the diversity of gut microbiota, which may relieve constipation.https://www.mdpi.com/2674-0311/2/2/15microbiotaα-diversityomega-3 unsaturated fatty acidsconstipation score |
| spellingShingle | Aki Kawamura Masaaki Sugita Perilla Oil, An Omega-3 Unsaturated Fatty Acid-Rich Oil, Enhances Diversity of Gut Microbiota and May Relieve Constipation in Sedentary Healthy Female: A Nonrandomized Placebo-Controlled Pilot Study Dietetics microbiota α-diversity omega-3 unsaturated fatty acids constipation score |
| title | Perilla Oil, An Omega-3 Unsaturated Fatty Acid-Rich Oil, Enhances Diversity of Gut Microbiota and May Relieve Constipation in Sedentary Healthy Female: A Nonrandomized Placebo-Controlled Pilot Study |
| title_full | Perilla Oil, An Omega-3 Unsaturated Fatty Acid-Rich Oil, Enhances Diversity of Gut Microbiota and May Relieve Constipation in Sedentary Healthy Female: A Nonrandomized Placebo-Controlled Pilot Study |
| title_fullStr | Perilla Oil, An Omega-3 Unsaturated Fatty Acid-Rich Oil, Enhances Diversity of Gut Microbiota and May Relieve Constipation in Sedentary Healthy Female: A Nonrandomized Placebo-Controlled Pilot Study |
| title_full_unstemmed | Perilla Oil, An Omega-3 Unsaturated Fatty Acid-Rich Oil, Enhances Diversity of Gut Microbiota and May Relieve Constipation in Sedentary Healthy Female: A Nonrandomized Placebo-Controlled Pilot Study |
| title_short | Perilla Oil, An Omega-3 Unsaturated Fatty Acid-Rich Oil, Enhances Diversity of Gut Microbiota and May Relieve Constipation in Sedentary Healthy Female: A Nonrandomized Placebo-Controlled Pilot Study |
| title_sort | perilla oil an omega 3 unsaturated fatty acid rich oil enhances diversity of gut microbiota and may relieve constipation in sedentary healthy female a nonrandomized placebo controlled pilot study |
| topic | microbiota α-diversity omega-3 unsaturated fatty acids constipation score |
| url | https://www.mdpi.com/2674-0311/2/2/15 |
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