Clinical observations of complex therapy of atopic dermatitis of moderate severity
Atopic dermatitis (AD) is more common in children, but can also occur in adults. Doctors of different specialties, including pediatricians, dermatologists, allergists-immunologists, gastroenterologists and infectious disease specialists deal with this problem. Despite the efforts of pediatricians, t...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2022-07-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/6975 |
| _version_ | 1797841885697409024 |
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| author | A. S. Stadnikova |
| author_facet | A. S. Stadnikova |
| author_sort | A. S. Stadnikova |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is more common in children, but can also occur in adults. Doctors of different specialties, including pediatricians, dermatologists, allergists-immunologists, gastroenterologists and infectious disease specialists deal with this problem. Despite the efforts of pediatricians, the problem of AD remains pressing. The progressive growth of this disease among children and increased persistence in adulthood make it important to study the mechanisms of AD not only for dermatology, but also for the health care system as a whole. The presence of pruritus is an obligatory manifestation of AD, which entails an inevitable decrease in the quality of life of patients. Thus, there are prerequisites for the emergence of new concepts of pathogenesis and the search for the most effective therapeutic methods of treatment. Currently, AD is considered as an interaction of endogenous (impaired immune response, insufficient function of the epidermal barrier) and exogenous factors (exposure to allergens, chemical or physical irritants, microorganisms). The work presents clinical cases of topical calcineurin inhibitor use in the treatment of moderate-to-severe AD. We presented patients with complaints of rashes accompanied by intense itching, on the skin of the extensor surfaces of the limbs, on the skin of the face and torso. Application of topical cal-cineurin inhibitor resulted in reduction of severity of subjective and objective symptoms of various forms of atd. The efficacy of topical calcineurin inhibitors in the treatment of atd with a pronounced anti-inflammatory and antipruritic effect was confirmed. Long-term staggered scheme of their use is the most pathogenetically justified and safe method of treatment of moderate forms of AD. |
| first_indexed | 2024-04-09T16:38:40Z |
| format | Article |
| id | doaj.art-260bf32cce5c4ae599b9b5439bf9b9db |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:38:40Z |
| publishDate | 2022-07-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-260bf32cce5c4ae599b9b5439bf9b9db2023-04-23T06:56:47ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902022-07-0101210010410.21518/2079-701X-2022-16-12-100-1046244Clinical observations of complex therapy of atopic dermatitis of moderate severityA. S. Stadnikova0Bashlyaeva Children's City Clinical HospitalAtopic dermatitis (AD) is more common in children, but can also occur in adults. Doctors of different specialties, including pediatricians, dermatologists, allergists-immunologists, gastroenterologists and infectious disease specialists deal with this problem. Despite the efforts of pediatricians, the problem of AD remains pressing. The progressive growth of this disease among children and increased persistence in adulthood make it important to study the mechanisms of AD not only for dermatology, but also for the health care system as a whole. The presence of pruritus is an obligatory manifestation of AD, which entails an inevitable decrease in the quality of life of patients. Thus, there are prerequisites for the emergence of new concepts of pathogenesis and the search for the most effective therapeutic methods of treatment. Currently, AD is considered as an interaction of endogenous (impaired immune response, insufficient function of the epidermal barrier) and exogenous factors (exposure to allergens, chemical or physical irritants, microorganisms). The work presents clinical cases of topical calcineurin inhibitor use in the treatment of moderate-to-severe AD. We presented patients with complaints of rashes accompanied by intense itching, on the skin of the extensor surfaces of the limbs, on the skin of the face and torso. Application of topical cal-cineurin inhibitor resulted in reduction of severity of subjective and objective symptoms of various forms of atd. The efficacy of topical calcineurin inhibitors in the treatment of atd with a pronounced anti-inflammatory and antipruritic effect was confirmed. Long-term staggered scheme of their use is the most pathogenetically justified and safe method of treatment of moderate forms of AD.https://www.med-sovet.pro/jour/article/view/6975atopic dermatitisdiagnosistreatmentchildrentopical calcineurin inhibitors |
| spellingShingle | A. S. Stadnikova Clinical observations of complex therapy of atopic dermatitis of moderate severity Медицинский совет atopic dermatitis diagnosis treatment children topical calcineurin inhibitors |
| title | Clinical observations of complex therapy of atopic dermatitis of moderate severity |
| title_full | Clinical observations of complex therapy of atopic dermatitis of moderate severity |
| title_fullStr | Clinical observations of complex therapy of atopic dermatitis of moderate severity |
| title_full_unstemmed | Clinical observations of complex therapy of atopic dermatitis of moderate severity |
| title_short | Clinical observations of complex therapy of atopic dermatitis of moderate severity |
| title_sort | clinical observations of complex therapy of atopic dermatitis of moderate severity |
| topic | atopic dermatitis diagnosis treatment children topical calcineurin inhibitors |
| url | https://www.med-sovet.pro/jour/article/view/6975 |
| work_keys_str_mv | AT asstadnikova clinicalobservationsofcomplextherapyofatopicdermatitisofmoderateseverity |