LRRK2 Inhibition by PF06447475 Antagonist Modulates Early Neuronal Damage after Spinal Cord Trauma

LRRK2 Inhibition by PF06447475 Antagonist Modulates Early Neuronal Damage after Spinal Cord Trauma

Spinal cord injury (SCI) is a devastating event followed by neurodegeneration, activation of the inflammatory cascade, and immune system. The leucine-rich-repeat kinase 2 (LRRK2) is a gene associated with Parkinson’s disease (PD), moreover, its kinase activity was found to be upregulated after insti...

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Bibliographic Details
Main Authors: Alessia Filippone, Deborah Mannino, Laura Cucinotta, Irene Paterniti, Emanuela Esposito, Michela Campolo
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antioxidants
Subjects:
neuroinflammation
spinal cord injury
cytokines
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/11/9/1634

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