Post-COVID Endocrine Disorders: Putative Role of Molecular Mimicry and Some Pathomorphological Correlates
In order to identify corresponding amino acid sequences (pentapeptides) between the SPs, MPs and NPs of human coronaviruses and human autoantigens targeted in autoimmune endocrinopathies, and for a comparative analysis of the various coronaviruses proteome and the proteome of human, the original com...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/3/522 |
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| author | Muslimbek Ghulomovich Normatov Vadim Evgenievich Karev Andrey Victorovich Kolobov Vera Arkad’yevna Mayevskaya Varvara Aleksandrovna Ryabkova Vladimir Josefovich Utekhin Leonid Pavlovich Churilov |
| author_facet | Muslimbek Ghulomovich Normatov Vadim Evgenievich Karev Andrey Victorovich Kolobov Vera Arkad’yevna Mayevskaya Varvara Aleksandrovna Ryabkova Vladimir Josefovich Utekhin Leonid Pavlovich Churilov |
| author_sort | Muslimbek Ghulomovich Normatov |
| collection | DOAJ |
| description | In order to identify corresponding amino acid sequences (pentapeptides) between the SPs, MPs and NPs of human coronaviruses and human autoantigens targeted in autoimmune endocrinopathies, and for a comparative analysis of the various coronaviruses proteome and the proteome of human, the original computer program was used. Quantitatively, SP, MP and NP of the human coronaviruses were found to share totally 117 minimal immune pentapeptide epitopes: 79 in SP, 14 in MP and 24 in NP, – with 18 autoantigens expressed by human endocrinocytes. The shared pentapeptides belong to the proteins of human endocrine cells. Samples of the pituitary, adrenal and thyroid from patients who died from coronavirus infection (COVID-19) were studied morphologically using histochemical methods. A high incidence of SARS-CoV-2 infection of endocrine cells was showed. The high affinity of SARS-CoV-2 the cells of the adenohypophysis was revealed, but there was no expression of viral proteins by the cells of the neurohypophysis. The foci of lesions in endocrine organs contained abundant lymphocytic infiltrates which may indicate the impact of autoimmune processes. Autoimmune disorders have a multi-faceted etiology and depend on polygenic predispose and additive action of many epigenetic and environmental factors causing hyperstimulation of imperfectly functioning immune system. It means that the phenomenon of molecular mimicry cannot be blamed as their single prerequisite, but it is just a tile in mosaic of autoimmunity. The facts revealed emphasize the need of endocrinological diagnostic alertness of a physician while observing patients with post-vaccination and post-COVID-19 health disorders. |
| first_indexed | 2024-03-11T09:47:44Z |
| format | Article |
| id | doaj.art-260e39407a0040b5bdbab2b7557198bc |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T09:47:44Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-260e39407a0040b5bdbab2b7557198bc2023-11-16T16:25:59ZengMDPI AGDiagnostics2075-44182023-01-0113352210.3390/diagnostics13030522Post-COVID Endocrine Disorders: Putative Role of Molecular Mimicry and Some Pathomorphological CorrelatesMuslimbek Ghulomovich Normatov0Vadim Evgenievich Karev1Andrey Victorovich Kolobov2Vera Arkad’yevna Mayevskaya3Varvara Aleksandrovna Ryabkova4Vladimir Josefovich Utekhin5Leonid Pavlovich Churilov6The Laboratory of the Mosaic of Autoimmunity and Department of Pathology, Saint Petersburg State University, 199034 Saint Petersburg, RussiaPediatric Research and Clinical Center for Infectious Diseases, 197022 Saint Petersburg, RussiaThe Laboratory of the Mosaic of Autoimmunity and Department of Pathology, Saint Petersburg State University, 199034 Saint Petersburg, RussiaThe Department of English, Saint Petersburg State University of Economics (UNECON), 191023 Saint Petersburg, RussiaThe Laboratory of the Mosaic of Autoimmunity and Department of Pathology, Saint Petersburg State University, 199034 Saint Petersburg, RussiaThe Laboratory of the Mosaic of Autoimmunity and Department of Pathology, Saint Petersburg State University, 199034 Saint Petersburg, RussiaThe Laboratory of the Mosaic of Autoimmunity and Department of Pathology, Saint Petersburg State University, 199034 Saint Petersburg, RussiaIn order to identify corresponding amino acid sequences (pentapeptides) between the SPs, MPs and NPs of human coronaviruses and human autoantigens targeted in autoimmune endocrinopathies, and for a comparative analysis of the various coronaviruses proteome and the proteome of human, the original computer program was used. Quantitatively, SP, MP and NP of the human coronaviruses were found to share totally 117 minimal immune pentapeptide epitopes: 79 in SP, 14 in MP and 24 in NP, – with 18 autoantigens expressed by human endocrinocytes. The shared pentapeptides belong to the proteins of human endocrine cells. Samples of the pituitary, adrenal and thyroid from patients who died from coronavirus infection (COVID-19) were studied morphologically using histochemical methods. A high incidence of SARS-CoV-2 infection of endocrine cells was showed. The high affinity of SARS-CoV-2 the cells of the adenohypophysis was revealed, but there was no expression of viral proteins by the cells of the neurohypophysis. The foci of lesions in endocrine organs contained abundant lymphocytic infiltrates which may indicate the impact of autoimmune processes. Autoimmune disorders have a multi-faceted etiology and depend on polygenic predispose and additive action of many epigenetic and environmental factors causing hyperstimulation of imperfectly functioning immune system. It means that the phenomenon of molecular mimicry cannot be blamed as their single prerequisite, but it is just a tile in mosaic of autoimmunity. The facts revealed emphasize the need of endocrinological diagnostic alertness of a physician while observing patients with post-vaccination and post-COVID-19 health disorders.https://www.mdpi.com/2075-4418/13/3/522antigen mimicryautoimmune diseasesSARS-CoV-2human coronavirusesthyroid glandpancreatic islets |
| spellingShingle | Muslimbek Ghulomovich Normatov Vadim Evgenievich Karev Andrey Victorovich Kolobov Vera Arkad’yevna Mayevskaya Varvara Aleksandrovna Ryabkova Vladimir Josefovich Utekhin Leonid Pavlovich Churilov Post-COVID Endocrine Disorders: Putative Role of Molecular Mimicry and Some Pathomorphological Correlates Diagnostics antigen mimicry autoimmune diseases SARS-CoV-2 human coronaviruses thyroid gland pancreatic islets |
| title | Post-COVID Endocrine Disorders: Putative Role of Molecular Mimicry and Some Pathomorphological Correlates |
| title_full | Post-COVID Endocrine Disorders: Putative Role of Molecular Mimicry and Some Pathomorphological Correlates |
| title_fullStr | Post-COVID Endocrine Disorders: Putative Role of Molecular Mimicry and Some Pathomorphological Correlates |
| title_full_unstemmed | Post-COVID Endocrine Disorders: Putative Role of Molecular Mimicry and Some Pathomorphological Correlates |
| title_short | Post-COVID Endocrine Disorders: Putative Role of Molecular Mimicry and Some Pathomorphological Correlates |
| title_sort | post covid endocrine disorders putative role of molecular mimicry and some pathomorphological correlates |
| topic | antigen mimicry autoimmune diseases SARS-CoV-2 human coronaviruses thyroid gland pancreatic islets |
| url | https://www.mdpi.com/2075-4418/13/3/522 |
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