Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center
Abstract Background To explore risk factors and the efficacy of treatment strategies for brain metastasis (BM) in squamous cell carcinoma (SCC) of the lung. Methods The clinical data of 188 pathologically confirmed as squamous cell carcinoma or adenosquamous carcinoma patients were studied retrospec...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-11-01
|
| Series: | Chinese Neurosurgical Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41016-017-0096-1 |
| _version_ | 1818512650935468032 |
|---|---|
| author | Bo Li Yanwei Liu Shuai Liu Xuenan Gu Xiaoguang Qiu |
| author_facet | Bo Li Yanwei Liu Shuai Liu Xuenan Gu Xiaoguang Qiu |
| author_sort | Bo Li |
| collection | DOAJ |
| description | Abstract Background To explore risk factors and the efficacy of treatment strategies for brain metastasis (BM) in squamous cell carcinoma (SCC) of the lung. Methods The clinical data of 188 pathologically confirmed as squamous cell carcinoma or adenosquamous carcinoma patients were studied retrospectively. Factors including age (<60 vs. ≥60), gender, stage at diagnosis, T status (T1–2 vs. T3–4), N status (N0–1 vs. N2–3), histology (squamous vs. adenosquamous), smoking history (non-smoker vs. current smoker) and serum tumor markers (normal vs. elevated) were analyzed. Results The incidence of BM was 19.1% (36/188) in our cohort. Patients who were female (p = 0.005), had advanced disease at diagnosis (p < 0.001), had adenosquamous carcinoma histology (p = 0.033) or had elevated serum level of CEA at diagnosis (p < 0.001) had significantly higher incidence of BM. In multivariate analysis, female (p = 0.034, HR = 18.874) and elevated serum level of CEA at diagnosis (p = 0.009, HR = 19.824) were independent risk factors of BM. BM patients who received additional systemic therapy after local therapy had significantly longer post-BM survival than those who received local therapy only (p = 0.004, HR = 0.058). Gemcitabine/platinum-containing regimen (GP) and taxans/platinum-containing regimen (TP) led to comparable brain-metastasis-free survival (BMFS) (p = 0.10). Conclusions Females and patients with elevated serum level of CEA at diagnosis had a higher risk of developing BM. The following systemic therapy after local therapy prolonged the survival of BM patient, but the efficacy of GP and TP was comparable in terms of preventing BM. |
| first_indexed | 2024-12-10T23:49:52Z |
| format | Article |
| id | doaj.art-260eec717f034f13aa9f636751100a37 |
| institution | Directory Open Access Journal |
| issn | 2057-4967 |
| language | English |
| last_indexed | 2024-12-10T23:49:52Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Neurosurgical Journal |
| spelling | doaj.art-260eec717f034f13aa9f636751100a372022-12-22T01:28:48ZengBMCChinese Neurosurgical Journal2057-49672017-11-01311910.1186/s41016-017-0096-1Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single centerBo Li0Yanwei Liu1Shuai Liu2Xuenan Gu3Xiaoguang Qiu4Department of Radiation Oncology, Beijing Tiantan Hospital affiliated to Capital Medical UniversityDepartment of Radiation Oncology, Beijing Tiantan Hospital affiliated to Capital Medical UniversityDepartment of Radiation Oncology, Beijing Tiantan Hospital affiliated to Capital Medical UniversityDepartment of Radiation Oncology, Beijing Tiantan Hospital affiliated to Capital Medical UniversityDepartment of Radiation Oncology, Beijing Tiantan Hospital affiliated to Capital Medical UniversityAbstract Background To explore risk factors and the efficacy of treatment strategies for brain metastasis (BM) in squamous cell carcinoma (SCC) of the lung. Methods The clinical data of 188 pathologically confirmed as squamous cell carcinoma or adenosquamous carcinoma patients were studied retrospectively. Factors including age (<60 vs. ≥60), gender, stage at diagnosis, T status (T1–2 vs. T3–4), N status (N0–1 vs. N2–3), histology (squamous vs. adenosquamous), smoking history (non-smoker vs. current smoker) and serum tumor markers (normal vs. elevated) were analyzed. Results The incidence of BM was 19.1% (36/188) in our cohort. Patients who were female (p = 0.005), had advanced disease at diagnosis (p < 0.001), had adenosquamous carcinoma histology (p = 0.033) or had elevated serum level of CEA at diagnosis (p < 0.001) had significantly higher incidence of BM. In multivariate analysis, female (p = 0.034, HR = 18.874) and elevated serum level of CEA at diagnosis (p = 0.009, HR = 19.824) were independent risk factors of BM. BM patients who received additional systemic therapy after local therapy had significantly longer post-BM survival than those who received local therapy only (p = 0.004, HR = 0.058). Gemcitabine/platinum-containing regimen (GP) and taxans/platinum-containing regimen (TP) led to comparable brain-metastasis-free survival (BMFS) (p = 0.10). Conclusions Females and patients with elevated serum level of CEA at diagnosis had a higher risk of developing BM. The following systemic therapy after local therapy prolonged the survival of BM patient, but the efficacy of GP and TP was comparable in terms of preventing BM.http://link.springer.com/article/10.1186/s41016-017-0096-1Brain metastasisChemotherapyNon-small cell lung cancerRisk factorSquamous cell carcinoma |
| spellingShingle | Bo Li Yanwei Liu Shuai Liu Xuenan Gu Xiaoguang Qiu Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center Chinese Neurosurgical Journal Brain metastasis Chemotherapy Non-small cell lung cancer Risk factor Squamous cell carcinoma |
| title | Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center |
| title_full | Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center |
| title_fullStr | Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center |
| title_full_unstemmed | Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center |
| title_short | Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center |
| title_sort | risk factors of brain metastasis of lung squamous cell carcinoma a retrospective analysis of 188 patients from single center |
| topic | Brain metastasis Chemotherapy Non-small cell lung cancer Risk factor Squamous cell carcinoma |
| url | http://link.springer.com/article/10.1186/s41016-017-0096-1 |
| work_keys_str_mv | AT boli riskfactorsofbrainmetastasisoflungsquamouscellcarcinomaaretrospectiveanalysisof188patientsfromsinglecenter AT yanweiliu riskfactorsofbrainmetastasisoflungsquamouscellcarcinomaaretrospectiveanalysisof188patientsfromsinglecenter AT shuailiu riskfactorsofbrainmetastasisoflungsquamouscellcarcinomaaretrospectiveanalysisof188patientsfromsinglecenter AT xuenangu riskfactorsofbrainmetastasisoflungsquamouscellcarcinomaaretrospectiveanalysisof188patientsfromsinglecenter AT xiaoguangqiu riskfactorsofbrainmetastasisoflungsquamouscellcarcinomaaretrospectiveanalysisof188patientsfromsinglecenter |