Association study between polycystic ovary syndrome and THADA gene polymorphisms in xinjiang uygur women
Background: The aim is to study the relationship between single nucleotide polymorphism (SNP) of polycystic ovary syndrome (PCOS) susceptibility locus in the THADA gene (rsl3429458) and PCOS in Xinjiang Uygur women. Methods: Seventy-seven Uygur patients with PCOS were enrolled from Reproductive Cent...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2017-01-01
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| Series: | Reproductive and Developmental Medicine |
| Subjects: | |
| Online Access: | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2017;volume=1;issue=2;spage=80;epage=83;aulast=Li |
| _version_ | 1818117950325915648 |
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| author | Xia Li Yu-Hong Huang Hai-Qing Tian Meng Zhang Xiao-Lin La |
| author_facet | Xia Li Yu-Hong Huang Hai-Qing Tian Meng Zhang Xiao-Lin La |
| author_sort | Xia Li |
| collection | DOAJ |
| description | Background: The aim is to study the relationship between single nucleotide polymorphism (SNP) of polycystic ovary syndrome (PCOS) susceptibility locus in the THADA gene (rsl3429458) and PCOS in Xinjiang Uygur women.
Methods: Seventy-seven Uygur patients with PCOS were enrolled from Reproductive Center of the First Affiliated Hospital of Xinjiang Medical University during May 2013 to January 2017; whereas 62 matched Uighur women of reproductive age with normal menstruation were set as the control group.
Results: (1) The levels of body mass index, luteinizing hormone, testosterone (T), blood glucose after 2 h of oral glucose tolerance test, insulin, triglyceride (TG) and low-density lipoprotein in PCOS group were much higher than control group (P < 0.05). (2) The frequencies of TT, TG, and GG of SNP13429458 in PCOS were 63.5%, 26.2%, and 10.3%, respectively; compared to the frequencies in the control group being 48.5%, 39.3%, and 22.2%, respectively. The difference between these two groups was statistically significant (P < 0.05). The allele frequency of T was much higher in PCOS than control women (76.5% vs. 61.4%, P < 0.05).
Conclusions: SNPl3429458 in the THADA gene is associated with the susceptibility of PCOS in Uygur women, which may be involved in the metabolic abnormality. |
| first_indexed | 2024-12-11T04:46:33Z |
| format | Article |
| id | doaj.art-26100a02da16414cb98632124d6a65d5 |
| institution | Directory Open Access Journal |
| issn | 2096-2924 |
| language | English |
| last_indexed | 2024-12-11T04:46:33Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Reproductive and Developmental Medicine |
| spelling | doaj.art-26100a02da16414cb98632124d6a65d52022-12-22T01:20:30ZengWolters Kluwer Health/LWWReproductive and Developmental Medicine2096-29242017-01-0112808310.4103/2096-2924.216859Association study between polycystic ovary syndrome and THADA gene polymorphisms in xinjiang uygur womenXia LiYu-Hong HuangHai-Qing TianMeng ZhangXiao-Lin LaBackground: The aim is to study the relationship between single nucleotide polymorphism (SNP) of polycystic ovary syndrome (PCOS) susceptibility locus in the THADA gene (rsl3429458) and PCOS in Xinjiang Uygur women. Methods: Seventy-seven Uygur patients with PCOS were enrolled from Reproductive Center of the First Affiliated Hospital of Xinjiang Medical University during May 2013 to January 2017; whereas 62 matched Uighur women of reproductive age with normal menstruation were set as the control group. Results: (1) The levels of body mass index, luteinizing hormone, testosterone (T), blood glucose after 2 h of oral glucose tolerance test, insulin, triglyceride (TG) and low-density lipoprotein in PCOS group were much higher than control group (P < 0.05). (2) The frequencies of TT, TG, and GG of SNP13429458 in PCOS were 63.5%, 26.2%, and 10.3%, respectively; compared to the frequencies in the control group being 48.5%, 39.3%, and 22.2%, respectively. The difference between these two groups was statistically significant (P < 0.05). The allele frequency of T was much higher in PCOS than control women (76.5% vs. 61.4%, P < 0.05). Conclusions: SNPl3429458 in the THADA gene is associated with the susceptibility of PCOS in Uygur women, which may be involved in the metabolic abnormality.http://www.repdevmed.org/article.asp?issn=2096-2924;year=2017;volume=1;issue=2;spage=80;epage=83;aulast=LiPolycystic Ovary Syndrome; Single Nucleotide Polymorphisms; THADA Gene; Uygur |
| spellingShingle | Xia Li Yu-Hong Huang Hai-Qing Tian Meng Zhang Xiao-Lin La Association study between polycystic ovary syndrome and THADA gene polymorphisms in xinjiang uygur women Reproductive and Developmental Medicine Polycystic Ovary Syndrome; Single Nucleotide Polymorphisms; THADA Gene; Uygur |
| title | Association study between polycystic ovary syndrome and THADA gene polymorphisms in xinjiang uygur women |
| title_full | Association study between polycystic ovary syndrome and THADA gene polymorphisms in xinjiang uygur women |
| title_fullStr | Association study between polycystic ovary syndrome and THADA gene polymorphisms in xinjiang uygur women |
| title_full_unstemmed | Association study between polycystic ovary syndrome and THADA gene polymorphisms in xinjiang uygur women |
| title_short | Association study between polycystic ovary syndrome and THADA gene polymorphisms in xinjiang uygur women |
| title_sort | association study between polycystic ovary syndrome and thada gene polymorphisms in xinjiang uygur women |
| topic | Polycystic Ovary Syndrome; Single Nucleotide Polymorphisms; THADA Gene; Uygur |
| url | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2017;volume=1;issue=2;spage=80;epage=83;aulast=Li |
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