FGF11 influences 3T3‐L1 preadipocyte differentiation by modulating the expression of PPARγ regulators
Fibroblast growth factor 11 (FGF11) is a member of the intracellular fibroblast growth factor superfamily. Here, we identified FGF11 as a novel mediator of adipogenesis. During 3T3‐L1 adipocyte differentiation, the expression of FGF11 decreased at the mitotic clonal expansion stage and increased at...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-04-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.12619 |
| _version_ | 1797821889081507840 |
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| author | Kyeong Won Lee Jae‐Yeon Jeong Young Jun An Jung‐Hyun Lee Hyung‐Soon Yim |
| author_facet | Kyeong Won Lee Jae‐Yeon Jeong Young Jun An Jung‐Hyun Lee Hyung‐Soon Yim |
| author_sort | Kyeong Won Lee |
| collection | DOAJ |
| description | Fibroblast growth factor 11 (FGF11) is a member of the intracellular fibroblast growth factor superfamily. Here, we identified FGF11 as a novel mediator of adipogenesis. During 3T3‐L1 adipocyte differentiation, the expression of FGF11 decreased at the mitotic clonal expansion stage and increased at the terminal differentiation stage. FGF11 knockdown reduced the expression of peroxisome proliferator‐activated receptor gamma (PPARγ), a master regulator of adipogenesis, resulting in the inhibition of adipocyte differentiation. Treatment with the PPARγ agonist rosiglitazone restored the inhibition of adipogenesis caused by FGF11 knockdown. We also report that the expression of the PPARγ regulators CCAAT/enhancer‐binding protein α, sterol regulatory element‐binding protein 1, KLF9, KLF2, GATA binding factor 2, and GATA binding factor 3 was influenced by FGF11. These results suggest that FGF11 indirectly controls the expression of PPARγ through modifying the expression of multiple PPARγ regulators, thereby mediating adipogenesis. |
| first_indexed | 2024-03-13T09:59:28Z |
| format | Article |
| id | doaj.art-2614ba34f1f74e318566a3ca54d5d7a5 |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-03-13T09:59:28Z |
| publishDate | 2019-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-2614ba34f1f74e318566a3ca54d5d7a52023-05-23T06:46:21ZengWileyFEBS Open Bio2211-54632019-04-019476978010.1002/2211-5463.12619FGF11 influences 3T3‐L1 preadipocyte differentiation by modulating the expression of PPARγ regulatorsKyeong Won Lee0Jae‐Yeon Jeong1Young Jun An2Jung‐Hyun Lee3Hyung‐Soon Yim4Marine Biotechnology Research Center Korea Institute of Ocean Science and Technology Busan KoreaMarine Biotechnology Research Center Korea Institute of Ocean Science and Technology Busan KoreaMarine Biotechnology Research Center Korea Institute of Ocean Science and Technology Busan KoreaMarine Biotechnology Research Center Korea Institute of Ocean Science and Technology Busan KoreaMarine Biotechnology Research Center Korea Institute of Ocean Science and Technology Busan KoreaFibroblast growth factor 11 (FGF11) is a member of the intracellular fibroblast growth factor superfamily. Here, we identified FGF11 as a novel mediator of adipogenesis. During 3T3‐L1 adipocyte differentiation, the expression of FGF11 decreased at the mitotic clonal expansion stage and increased at the terminal differentiation stage. FGF11 knockdown reduced the expression of peroxisome proliferator‐activated receptor gamma (PPARγ), a master regulator of adipogenesis, resulting in the inhibition of adipocyte differentiation. Treatment with the PPARγ agonist rosiglitazone restored the inhibition of adipogenesis caused by FGF11 knockdown. We also report that the expression of the PPARγ regulators CCAAT/enhancer‐binding protein α, sterol regulatory element‐binding protein 1, KLF9, KLF2, GATA binding factor 2, and GATA binding factor 3 was influenced by FGF11. These results suggest that FGF11 indirectly controls the expression of PPARγ through modifying the expression of multiple PPARγ regulators, thereby mediating adipogenesis.https://doi.org/10.1002/2211-5463.126193T3‐L1adipocyteadipogenesisfibroblast growth factor 11PPARγ |
| spellingShingle | Kyeong Won Lee Jae‐Yeon Jeong Young Jun An Jung‐Hyun Lee Hyung‐Soon Yim FGF11 influences 3T3‐L1 preadipocyte differentiation by modulating the expression of PPARγ regulators FEBS Open Bio 3T3‐L1 adipocyte adipogenesis fibroblast growth factor 11 PPARγ |
| title | FGF11 influences 3T3‐L1 preadipocyte differentiation by modulating the expression of PPARγ regulators |
| title_full | FGF11 influences 3T3‐L1 preadipocyte differentiation by modulating the expression of PPARγ regulators |
| title_fullStr | FGF11 influences 3T3‐L1 preadipocyte differentiation by modulating the expression of PPARγ regulators |
| title_full_unstemmed | FGF11 influences 3T3‐L1 preadipocyte differentiation by modulating the expression of PPARγ regulators |
| title_short | FGF11 influences 3T3‐L1 preadipocyte differentiation by modulating the expression of PPARγ regulators |
| title_sort | fgf11 influences 3t3 l1 preadipocyte differentiation by modulating the expression of pparγ regulators |
| topic | 3T3‐L1 adipocyte adipogenesis fibroblast growth factor 11 PPARγ |
| url | https://doi.org/10.1002/2211-5463.12619 |
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