The hematologic profile of Filipino HIV-infected individuals and its association with CD4 counts
Introduction: Hematologic abnormalities are common in HIV and involve all blood cell lineages. A study on cytopenias, as correlated with disease progression, can be valuable in resource-limited settings. This study aimed to determine the hematologic profile of HIV patients and its association with C...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Hematology, Transfusion and Cell Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137920313110 |
| _version_ | 1798003268658397184 |
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| author | Preeti Prerna M. Vaswani Issa Rufina Senga-Tang Jean Rachel M. Catapia Cybele Lara R. Abad Teresita E. Dumagay |
| author_facet | Preeti Prerna M. Vaswani Issa Rufina Senga-Tang Jean Rachel M. Catapia Cybele Lara R. Abad Teresita E. Dumagay |
| author_sort | Preeti Prerna M. Vaswani |
| collection | DOAJ |
| description | Introduction: Hematologic abnormalities are common in HIV and involve all blood cell lineages. A study on cytopenias, as correlated with disease progression, can be valuable in resource-limited settings. This study aimed to determine the hematologic profile of HIV patients and its association with CD4 count and antiretroviral (ARV) treatment. Methods: This is a retrospective cohort study involving adult Filipino HIV patients with complete blood count (CBC) and CD4 count determinations prior to the initiation of ARV treatment and after ≥6 months of ARV treatment. Logistic regression was performed to determine the association between cytopenias and a CD4 count <200 cells/µL. Results: The study included 302 patients. Anemia was the most common cytopenia. Anemia and leukopenia were associated with an increased likelihood of having a CD4 count <200 cells/µL in ARV-naïve patients. In ARV-treated patients, leukopenia was associated with an increased probability of having a CD4 count <200 cells/µL. An increase in hemoglobin, white blood cell (WBC) and platelet counts was observed after ≥6 months of ARV treatment. Conclusion: Anemia and leukopenia can be used as markers of immune status in HIV-infected individuals and improvement in the CBC parameters can be used to assess response to ARV treatment. Routine monitoring of hematologic parameters is recommended. |
| first_indexed | 2024-04-11T12:04:55Z |
| format | Article |
| id | doaj.art-26190e89de1741cab09765fa1abd6d7f |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-04-11T12:04:55Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-26190e89de1741cab09765fa1abd6d7f2022-12-22T04:24:45ZengElsevierHematology, Transfusion and Cell Therapy2531-13792022-07-01443307313The hematologic profile of Filipino HIV-infected individuals and its association with CD4 countsPreeti Prerna M. Vaswani0Issa Rufina Senga-Tang1Jean Rachel M. Catapia2Cybele Lara R. Abad3Teresita E. Dumagay4Division of Hematology, Department of Medicine, University of the Philippines, Philippine General Hospital, Manila, Philippines; Corresponding author.Division of Infectious Diseases, Department of Medicine, University of the Philippines, Philippine General Hospital, Manila, PhilippinesDivision of Hematology, Department of Medicine, University of the Philippines, Philippine General Hospital, Manila, PhilippinesDivision of Infectious Diseases, Department of Medicine, University of the Philippines, Philippine General Hospital, Manila, PhilippinesDivision of Hematology, Department of Medicine, University of the Philippines, Philippine General Hospital, Manila, PhilippinesIntroduction: Hematologic abnormalities are common in HIV and involve all blood cell lineages. A study on cytopenias, as correlated with disease progression, can be valuable in resource-limited settings. This study aimed to determine the hematologic profile of HIV patients and its association with CD4 count and antiretroviral (ARV) treatment. Methods: This is a retrospective cohort study involving adult Filipino HIV patients with complete blood count (CBC) and CD4 count determinations prior to the initiation of ARV treatment and after ≥6 months of ARV treatment. Logistic regression was performed to determine the association between cytopenias and a CD4 count <200 cells/µL. Results: The study included 302 patients. Anemia was the most common cytopenia. Anemia and leukopenia were associated with an increased likelihood of having a CD4 count <200 cells/µL in ARV-naïve patients. In ARV-treated patients, leukopenia was associated with an increased probability of having a CD4 count <200 cells/µL. An increase in hemoglobin, white blood cell (WBC) and platelet counts was observed after ≥6 months of ARV treatment. Conclusion: Anemia and leukopenia can be used as markers of immune status in HIV-infected individuals and improvement in the CBC parameters can be used to assess response to ARV treatment. Routine monitoring of hematologic parameters is recommended.http://www.sciencedirect.com/science/article/pii/S2531137920313110HIV infectionsAnemiaLeukopeniaHighly active Antiretroviral therapy |
| spellingShingle | Preeti Prerna M. Vaswani Issa Rufina Senga-Tang Jean Rachel M. Catapia Cybele Lara R. Abad Teresita E. Dumagay The hematologic profile of Filipino HIV-infected individuals and its association with CD4 counts Hematology, Transfusion and Cell Therapy HIV infections Anemia Leukopenia Highly active Antiretroviral therapy |
| title | The hematologic profile of Filipino HIV-infected individuals and its association with CD4 counts |
| title_full | The hematologic profile of Filipino HIV-infected individuals and its association with CD4 counts |
| title_fullStr | The hematologic profile of Filipino HIV-infected individuals and its association with CD4 counts |
| title_full_unstemmed | The hematologic profile of Filipino HIV-infected individuals and its association with CD4 counts |
| title_short | The hematologic profile of Filipino HIV-infected individuals and its association with CD4 counts |
| title_sort | hematologic profile of filipino hiv infected individuals and its association with cd4 counts |
| topic | HIV infections Anemia Leukopenia Highly active Antiretroviral therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2531137920313110 |
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