Staphylococcus aureus Bacteremia in Children of Rural Areas of The Gambia, 2008–2015
Staphylococcus aureus bacteremia is a substantial cause of childhood disease and death, but few studies have described its epidemiology in developing countries. Using a population-based surveillance system for pneumonia, sepsis, and meningitis, we estimated S. aureus bacteremia incidence and the cas...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2019-04-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/25/4/18-0935_article |
| _version_ | 1828836278325477376 |
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| author | Aderonke Odutola Christian Bottomley Syed A. Zaman Jodi Lindsay Muhammed Shah Ilias Hossain Malick Ndiaye Chidebere D.I. Osuorah Yekini Olatunji Henry Badji Usman N.A. Ikumapayi Ahmad Manjang Rasheed Salaudeen Lamin Ceesay Momodou Jasseh Richard A. Adegbola Tumani Corrah Philip C. Hill Brian M. Greenwood Grant A. Mackenzie |
| author_facet | Aderonke Odutola Christian Bottomley Syed A. Zaman Jodi Lindsay Muhammed Shah Ilias Hossain Malick Ndiaye Chidebere D.I. Osuorah Yekini Olatunji Henry Badji Usman N.A. Ikumapayi Ahmad Manjang Rasheed Salaudeen Lamin Ceesay Momodou Jasseh Richard A. Adegbola Tumani Corrah Philip C. Hill Brian M. Greenwood Grant A. Mackenzie |
| author_sort | Aderonke Odutola |
| collection | DOAJ |
| description | Staphylococcus aureus bacteremia is a substantial cause of childhood disease and death, but few studies have described its epidemiology in developing countries. Using a population-based surveillance system for pneumonia, sepsis, and meningitis, we estimated S. aureus bacteremia incidence and the case-fatality ratio in children <5 years of age in 2 regions in the eastern part of The Gambia during 2008–2015. Among 33,060 children with suspected pneumonia, sepsis, or meningitis, we performed blood culture for 27,851; of 1,130 patients with bacteremia, 198 (17.5%) were positive for S. aureus. S. aureus bacteremia incidence was 78 (95% CI 67–91) cases/100,000 person-years in children <5 years of age and 2,080 (95% CI 1,621–2,627) cases/100,000 person-years in neonates. Incidence did not change after introduction of the pneumococcal conjugate vaccine. The case-fatality ratio was 14.1% (95% CI 9.6%–19.8%). Interventions are needed to reduce the S. aureus bacteremia burden in The Gambia, particularly among neonates. |
| first_indexed | 2024-12-12T18:19:14Z |
| format | Article |
| id | doaj.art-2619811fc910473ba9e6ff948f2e9a88 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-12T18:19:14Z |
| publishDate | 2019-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-2619811fc910473ba9e6ff948f2e9a882022-12-22T00:16:11ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592019-04-0125470170910.3201/eid2504.180935Staphylococcus aureus Bacteremia in Children of Rural Areas of The Gambia, 2008–2015Aderonke OdutolaChristian BottomleySyed A. ZamanJodi LindsayMuhammed ShahIlias HossainMalick NdiayeChidebere D.I. OsuorahYekini OlatunjiHenry BadjiUsman N.A. IkumapayiAhmad ManjangRasheed SalaudeenLamin CeesayMomodou JassehRichard A. AdegbolaTumani CorrahPhilip C. HillBrian M. GreenwoodGrant A. MackenzieStaphylococcus aureus bacteremia is a substantial cause of childhood disease and death, but few studies have described its epidemiology in developing countries. Using a population-based surveillance system for pneumonia, sepsis, and meningitis, we estimated S. aureus bacteremia incidence and the case-fatality ratio in children <5 years of age in 2 regions in the eastern part of The Gambia during 2008–2015. Among 33,060 children with suspected pneumonia, sepsis, or meningitis, we performed blood culture for 27,851; of 1,130 patients with bacteremia, 198 (17.5%) were positive for S. aureus. S. aureus bacteremia incidence was 78 (95% CI 67–91) cases/100,000 person-years in children <5 years of age and 2,080 (95% CI 1,621–2,627) cases/100,000 person-years in neonates. Incidence did not change after introduction of the pneumococcal conjugate vaccine. The case-fatality ratio was 14.1% (95% CI 9.6%–19.8%). Interventions are needed to reduce the S. aureus bacteremia burden in The Gambia, particularly among neonates.https://wwwnc.cdc.gov/eid/article/25/4/18-0935_articleStaphylococcus aureusbacteremiaGambiachildrenfatalityepidemiology |
| spellingShingle | Aderonke Odutola Christian Bottomley Syed A. Zaman Jodi Lindsay Muhammed Shah Ilias Hossain Malick Ndiaye Chidebere D.I. Osuorah Yekini Olatunji Henry Badji Usman N.A. Ikumapayi Ahmad Manjang Rasheed Salaudeen Lamin Ceesay Momodou Jasseh Richard A. Adegbola Tumani Corrah Philip C. Hill Brian M. Greenwood Grant A. Mackenzie Staphylococcus aureus Bacteremia in Children of Rural Areas of The Gambia, 2008–2015 Emerging Infectious Diseases Staphylococcus aureus bacteremia Gambia children fatality epidemiology |
| title | Staphylococcus aureus Bacteremia in Children of Rural Areas of The Gambia, 2008–2015 |
| title_full | Staphylococcus aureus Bacteremia in Children of Rural Areas of The Gambia, 2008–2015 |
| title_fullStr | Staphylococcus aureus Bacteremia in Children of Rural Areas of The Gambia, 2008–2015 |
| title_full_unstemmed | Staphylococcus aureus Bacteremia in Children of Rural Areas of The Gambia, 2008–2015 |
| title_short | Staphylococcus aureus Bacteremia in Children of Rural Areas of The Gambia, 2008–2015 |
| title_sort | staphylococcus aureus bacteremia in children of rural areas of the gambia 2008 2015 |
| topic | Staphylococcus aureus bacteremia Gambia children fatality epidemiology |
| url | https://wwwnc.cdc.gov/eid/article/25/4/18-0935_article |
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