Piranha solution treatment: A facile method for improving the antithrombotic ability and regulating smooth muscle cell growth on blood contact materials
Blood contact materials require strong anti-fouling capabilities to avoid thrombus formation. Recently, TiO2-based photocatalytic antithrombotic treatment has gained focus. Nevertheless, this method is restricted to titanium materials with photocatalytic abilities. This study offers an alternative s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1166334/full |
| _version_ | 1827992535006445568 |
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| author | Yuzhen Liao Yuzhen Liao Xiao Chen Xiao Chen Yutong Jiang Chao Qu Xiaoqi Liu Ansha Zhao Ping Yang Nan Huang Jiang Chen |
| author_facet | Yuzhen Liao Yuzhen Liao Xiao Chen Xiao Chen Yutong Jiang Chao Qu Xiaoqi Liu Ansha Zhao Ping Yang Nan Huang Jiang Chen |
| author_sort | Yuzhen Liao |
| collection | DOAJ |
| description | Blood contact materials require strong anti-fouling capabilities to avoid thrombus formation. Recently, TiO2-based photocatalytic antithrombotic treatment has gained focus. Nevertheless, this method is restricted to titanium materials with photocatalytic abilities. This study offers an alternative solution that can be applied to a broader range of materials: piranha solution treatment. Our findings revealed that the free radicals generated by the treatment effectively altered the surface physicochemical properties of various inorganic materials, enhancing their surface hydrophilicity and oxidizing organic contaminants, thus improving their antithrombotic properties. Additionally, the treatment resulted in contrasting effects on the cellular affinity of SS and TiO2. While it significantly reduced the adhesion and proliferation of SMCs on SS surfaces, it significantly enhanced these on TiO2 surfaces. These observations suggested that the impact of the piranha solution treatment on the cellular affinity of biomaterials was closely tied to the intrinsic properties of the materials. Thus, materials suitable for piranha solution treatment could be selected based on the functional requirements of implantable medical devices. In conclusion, the broad applicability of piranha solution surface modification technology in both blood-contact and bone implant materials highlights its promising prospects. |
| first_indexed | 2024-04-10T04:06:30Z |
| format | Article |
| id | doaj.art-261b650e36ac4625ad5b54f09544c91d |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-10T04:06:30Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-261b650e36ac4625ad5b54f09544c91d2023-03-13T05:19:32ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-03-011110.3389/fbioe.2023.11663341166334Piranha solution treatment: A facile method for improving the antithrombotic ability and regulating smooth muscle cell growth on blood contact materialsYuzhen Liao0Yuzhen Liao1Xiao Chen2Xiao Chen3Yutong Jiang4Chao Qu5Xiaoqi Liu6Ansha Zhao7Ping Yang8Nan Huang9Jiang Chen10The Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaKey Laboratory for Advanced Technologies of Materials, Ministry of Education, Institute of Biomaterials and Surface Engineering, Southwest Jiaotong University, Chengdu, ChinaThe Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaKey Laboratory for Advanced Technologies of Materials, Ministry of Education, Institute of Biomaterials and Surface Engineering, Southwest Jiaotong University, Chengdu, ChinaSchool of Stomatology of Guizhou Medical University, Guiyang, Guizhou, ChinaThe Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSichuan Provincial Key Laboratory for Human Disease Gene Study, The Department of Medical Genetics, The Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology, Chengdu, ChinaSichuan Provincial Key Laboratory for Human Disease Gene Study, The Department of Medical Genetics, The Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology, Chengdu, ChinaSichuan Provincial Key Laboratory for Human Disease Gene Study, The Department of Medical Genetics, The Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology, Chengdu, ChinaSichuan Provincial Key Laboratory for Human Disease Gene Study, The Department of Medical Genetics, The Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology, Chengdu, ChinaThe Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaBlood contact materials require strong anti-fouling capabilities to avoid thrombus formation. Recently, TiO2-based photocatalytic antithrombotic treatment has gained focus. Nevertheless, this method is restricted to titanium materials with photocatalytic abilities. This study offers an alternative solution that can be applied to a broader range of materials: piranha solution treatment. Our findings revealed that the free radicals generated by the treatment effectively altered the surface physicochemical properties of various inorganic materials, enhancing their surface hydrophilicity and oxidizing organic contaminants, thus improving their antithrombotic properties. Additionally, the treatment resulted in contrasting effects on the cellular affinity of SS and TiO2. While it significantly reduced the adhesion and proliferation of SMCs on SS surfaces, it significantly enhanced these on TiO2 surfaces. These observations suggested that the impact of the piranha solution treatment on the cellular affinity of biomaterials was closely tied to the intrinsic properties of the materials. Thus, materials suitable for piranha solution treatment could be selected based on the functional requirements of implantable medical devices. In conclusion, the broad applicability of piranha solution surface modification technology in both blood-contact and bone implant materials highlights its promising prospects.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1166334/fullpiranha solution treatmentfree radicalanti-blood foulinganticoagualant abilitysmooth musce cell |
| spellingShingle | Yuzhen Liao Yuzhen Liao Xiao Chen Xiao Chen Yutong Jiang Chao Qu Xiaoqi Liu Ansha Zhao Ping Yang Nan Huang Jiang Chen Piranha solution treatment: A facile method for improving the antithrombotic ability and regulating smooth muscle cell growth on blood contact materials Frontiers in Bioengineering and Biotechnology piranha solution treatment free radical anti-blood fouling anticoagualant ability smooth musce cell |
| title | Piranha solution treatment: A facile method for improving the antithrombotic ability and regulating smooth muscle cell growth on blood contact materials |
| title_full | Piranha solution treatment: A facile method for improving the antithrombotic ability and regulating smooth muscle cell growth on blood contact materials |
| title_fullStr | Piranha solution treatment: A facile method for improving the antithrombotic ability and regulating smooth muscle cell growth on blood contact materials |
| title_full_unstemmed | Piranha solution treatment: A facile method for improving the antithrombotic ability and regulating smooth muscle cell growth on blood contact materials |
| title_short | Piranha solution treatment: A facile method for improving the antithrombotic ability and regulating smooth muscle cell growth on blood contact materials |
| title_sort | piranha solution treatment a facile method for improving the antithrombotic ability and regulating smooth muscle cell growth on blood contact materials |
| topic | piranha solution treatment free radical anti-blood fouling anticoagualant ability smooth musce cell |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1166334/full |
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