Influence of short-term changes in sex hormones on serum concentrations of cellular adhesion molecules in young healthy women
Aim To determine if short-term changes in sex hormones (such as cyclic changes within the menstrual cycle) can influence the serumconcentration of soluble cell adhesion molecules (CAMs).Methods Sixteen healthy young women with normal cycles participated in this study. Serum levels of sICAM-1, sVCAM-...
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| Format: | Article |
| Language: | English |
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Medical Association of Zenica-Doboj Canton
2012-02-01
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| Series: | Medicinski Glasnik |
| Subjects: | |
| Online Access: | http://ljkzedo.com.ba/medglasnik/vol91/5.pdf |
| _version_ | 1828403827388186624 |
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| author | Ivana Begić Ana Čavka Martina Mihalj Tatjana Baćun Ines Drenjančević |
| author_facet | Ivana Begić Ana Čavka Martina Mihalj Tatjana Baćun Ines Drenjančević |
| author_sort | Ivana Begić |
| collection | DOAJ |
| description | Aim To determine if short-term changes in sex hormones (such as cyclic changes within the menstrual cycle) can influence the serumconcentration of soluble cell adhesion molecules (CAMs).Methods Sixteen healthy young women with normal cycles participated in this study. Serum levels of sICAM-1, sVCAM-1 and E-selectin were determined in three different phases of the menstrual cycle: a) early follicular (EF) phase, b) ovulatory (O) phase and c) midluteal (ML) phase, by standardized ELISA-based kits. To confirm the exact assessment of menstrual cycle phases, serum levels of estrogen, progesterone, LH and FSH were measured. Results There were significant oscillations in serum female sex hormones concentration over the cycle duration, as expected the level of estrogen (E2) and progesterone (PROG) was the lowest in EF phase, the highest E2 appeared in O phase, and both E2 and PROG were present in high concentrations during ML phase. There was a significant positive correlation between E2 and serum soluble ICAM -1 concentrations (p=0,041, correlation coefficient 0,306). However, there was no significant change in other soluble CAMs concentration during the menstrual cycle. Conclusion Results of our study suggest that short-term changes in female sex hormone levels could modulate expression of soluble ICAM-1, but not VCAM -1 or E-selectin in extent that would affect a young woman’s health. |
| first_indexed | 2024-12-10T10:25:23Z |
| format | Article |
| id | doaj.art-261cb66b4dfd432f82cd1d0a6a1d5389 |
| institution | Directory Open Access Journal |
| issn | 1840-0132 1840-2445 |
| language | English |
| last_indexed | 2024-12-10T10:25:23Z |
| publishDate | 2012-02-01 |
| publisher | Medical Association of Zenica-Doboj Canton |
| record_format | Article |
| series | Medicinski Glasnik |
| spelling | doaj.art-261cb66b4dfd432f82cd1d0a6a1d53892022-12-22T01:52:44ZengMedical Association of Zenica-Doboj CantonMedicinski Glasnik1840-01321840-24452012-02-01913236Influence of short-term changes in sex hormones on serum concentrations of cellular adhesion molecules in young healthy womenIvana BegićAna ČavkaMartina MihaljTatjana BaćunInes DrenjančevićAim To determine if short-term changes in sex hormones (such as cyclic changes within the menstrual cycle) can influence the serumconcentration of soluble cell adhesion molecules (CAMs).Methods Sixteen healthy young women with normal cycles participated in this study. Serum levels of sICAM-1, sVCAM-1 and E-selectin were determined in three different phases of the menstrual cycle: a) early follicular (EF) phase, b) ovulatory (O) phase and c) midluteal (ML) phase, by standardized ELISA-based kits. To confirm the exact assessment of menstrual cycle phases, serum levels of estrogen, progesterone, LH and FSH were measured. Results There were significant oscillations in serum female sex hormones concentration over the cycle duration, as expected the level of estrogen (E2) and progesterone (PROG) was the lowest in EF phase, the highest E2 appeared in O phase, and both E2 and PROG were present in high concentrations during ML phase. There was a significant positive correlation between E2 and serum soluble ICAM -1 concentrations (p=0,041, correlation coefficient 0,306). However, there was no significant change in other soluble CAMs concentration during the menstrual cycle. Conclusion Results of our study suggest that short-term changes in female sex hormone levels could modulate expression of soluble ICAM-1, but not VCAM -1 or E-selectin in extent that would affect a young woman’s health.http://ljkzedo.com.ba/medglasnik/vol91/5.pdfcell adhesion moleculesfemale sex hormonessICAM-1sVCAM-1E-selectin |
| spellingShingle | Ivana Begić Ana Čavka Martina Mihalj Tatjana Baćun Ines Drenjančević Influence of short-term changes in sex hormones on serum concentrations of cellular adhesion molecules in young healthy women Medicinski Glasnik cell adhesion molecules female sex hormones sICAM-1 sVCAM-1 E-selectin |
| title | Influence of short-term changes in sex hormones on serum concentrations of cellular adhesion molecules in young healthy women |
| title_full | Influence of short-term changes in sex hormones on serum concentrations of cellular adhesion molecules in young healthy women |
| title_fullStr | Influence of short-term changes in sex hormones on serum concentrations of cellular adhesion molecules in young healthy women |
| title_full_unstemmed | Influence of short-term changes in sex hormones on serum concentrations of cellular adhesion molecules in young healthy women |
| title_short | Influence of short-term changes in sex hormones on serum concentrations of cellular adhesion molecules in young healthy women |
| title_sort | influence of short term changes in sex hormones on serum concentrations of cellular adhesion molecules in young healthy women |
| topic | cell adhesion molecules female sex hormones sICAM-1 sVCAM-1 E-selectin |
| url | http://ljkzedo.com.ba/medglasnik/vol91/5.pdf |
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