Prevalences of diabetes mellitus and carotid atherosclerosis and their relationships in middle-aged adults and elders: a community-based study
Background/Purpose: Atherosclerosis and diabetes mellitus (DM) are both severe chronic diseases that cause huge burdens on patients’ families and societies. Connections between the two diseases have brought high attention recently, however, population-based study with large sample size was few. The...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664621004770 |
| _version_ | 1811252230667370496 |
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| author | Tzu-Wei Wu Chao-Liang Chou Chun-Fang Cheng Shu-Xin Lu Li-Yu Wang |
| author_facet | Tzu-Wei Wu Chao-Liang Chou Chun-Fang Cheng Shu-Xin Lu Li-Yu Wang |
| author_sort | Tzu-Wei Wu |
| collection | DOAJ |
| description | Background/Purpose: Atherosclerosis and diabetes mellitus (DM) are both severe chronic diseases that cause huge burdens on patients’ families and societies. Connections between the two diseases have brought high attention recently, however, population-based study with large sample size was few. The study aimed to explore the relationship between carotid atherosclerosis and DM. Methods: We enrolled 3908 adults aged 40–74 years from communities and measured their cardio–metabolic profiles and scanned their carotid arteries bilaterally. Results: The overall prevalence rates of carotid plaque and DM were 34.4 and 10.7%, respectively. The age-specific prevalence rates of DM and carotid plaque were nearly linearly correlated in both sexes (both Pearson's correlation coefficient r > 0.97). The prevalence rates of carotid plaque, total plaque number ≥3, maximum diameter stenosis ≥30%, and plaque score ≥3 were 53.6, 24.8, 19.1, and 28.6%, respectively, in DM patients and were 32.1, 9.4, 9.8, and 11.2%, respectively, in non-DM controls. After adjustment for other conventional risk factors, the multivariable-adjusted OR of having carotid plaque was 1.60 (95% CI 1.27–2.01) and were 2.06 (95% CI 1.55–2.75), 1.33 (95% CI 0.99–1.78), and 2.03 (95% CI 1.55–2.65) for total plaque number ≥3, maximum diameter stenosis ≥30%, and plaque score ≥3, respectively. Conclusion: We demonstrated that prevalences of DM were linearly correlated with prevalences of carotid plaque and DM patients had higher prevalence rates of carotid plaque and more advanced carotid atherosclerosis than non-DM controls. Our results indicated the need to address the role of DM in atherosclerosis development. |
| first_indexed | 2024-04-12T16:32:42Z |
| format | Article |
| id | doaj.art-26202d44a608461a8cb8895e1793a2e3 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-04-12T16:32:42Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-26202d44a608461a8cb8895e1793a2e32022-12-22T03:25:06ZengElsevierJournal of the Formosan Medical Association0929-66462022-06-01121611331140Prevalences of diabetes mellitus and carotid atherosclerosis and their relationships in middle-aged adults and elders: a community-based studyTzu-Wei Wu0Chao-Liang Chou1Chun-Fang Cheng2Shu-Xin Lu3Li-Yu Wang4Department of Medicine, MacKay Medical College, New Taipei City, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City, Taiwan; Department of Neurology, MacKay Memorial Hospital, New Taipei City, TaiwanTamsui and Bali Health Station, Department of Health, New Taipei City Government, New Taipei City, TaiwanDepartment of Neurology, MacKay Memorial Hospital, New Taipei City, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City, Taiwan; Corresponding author. Department of Medicine, MacKay Medical College, No. 46, Sec. 3,Jhong-Jheng Rd, San-Jhih District, New Taipei City, Taiwan. Fax: +886 2 26365522.Background/Purpose: Atherosclerosis and diabetes mellitus (DM) are both severe chronic diseases that cause huge burdens on patients’ families and societies. Connections between the two diseases have brought high attention recently, however, population-based study with large sample size was few. The study aimed to explore the relationship between carotid atherosclerosis and DM. Methods: We enrolled 3908 adults aged 40–74 years from communities and measured their cardio–metabolic profiles and scanned their carotid arteries bilaterally. Results: The overall prevalence rates of carotid plaque and DM were 34.4 and 10.7%, respectively. The age-specific prevalence rates of DM and carotid plaque were nearly linearly correlated in both sexes (both Pearson's correlation coefficient r > 0.97). The prevalence rates of carotid plaque, total plaque number ≥3, maximum diameter stenosis ≥30%, and plaque score ≥3 were 53.6, 24.8, 19.1, and 28.6%, respectively, in DM patients and were 32.1, 9.4, 9.8, and 11.2%, respectively, in non-DM controls. After adjustment for other conventional risk factors, the multivariable-adjusted OR of having carotid plaque was 1.60 (95% CI 1.27–2.01) and were 2.06 (95% CI 1.55–2.75), 1.33 (95% CI 0.99–1.78), and 2.03 (95% CI 1.55–2.65) for total plaque number ≥3, maximum diameter stenosis ≥30%, and plaque score ≥3, respectively. Conclusion: We demonstrated that prevalences of DM were linearly correlated with prevalences of carotid plaque and DM patients had higher prevalence rates of carotid plaque and more advanced carotid atherosclerosis than non-DM controls. Our results indicated the need to address the role of DM in atherosclerosis development.http://www.sciencedirect.com/science/article/pii/S0929664621004770Carotid atherosclerosisDiabetes mellitusDyslipidemiaPopulation-based studyAssociation study |
| spellingShingle | Tzu-Wei Wu Chao-Liang Chou Chun-Fang Cheng Shu-Xin Lu Li-Yu Wang Prevalences of diabetes mellitus and carotid atherosclerosis and their relationships in middle-aged adults and elders: a community-based study Journal of the Formosan Medical Association Carotid atherosclerosis Diabetes mellitus Dyslipidemia Population-based study Association study |
| title | Prevalences of diabetes mellitus and carotid atherosclerosis and their relationships in middle-aged adults and elders: a community-based study |
| title_full | Prevalences of diabetes mellitus and carotid atherosclerosis and their relationships in middle-aged adults and elders: a community-based study |
| title_fullStr | Prevalences of diabetes mellitus and carotid atherosclerosis and their relationships in middle-aged adults and elders: a community-based study |
| title_full_unstemmed | Prevalences of diabetes mellitus and carotid atherosclerosis and their relationships in middle-aged adults and elders: a community-based study |
| title_short | Prevalences of diabetes mellitus and carotid atherosclerosis and their relationships in middle-aged adults and elders: a community-based study |
| title_sort | prevalences of diabetes mellitus and carotid atherosclerosis and their relationships in middle aged adults and elders a community based study |
| topic | Carotid atherosclerosis Diabetes mellitus Dyslipidemia Population-based study Association study |
| url | http://www.sciencedirect.com/science/article/pii/S0929664621004770 |
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