A Comparative Study Between Two Different Doses of Dexmedetomidine Combined with Ropivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block
<p><strong>Background:</strong> Though, various studies have been conducted to show the efficacy of dexmedetomidine as an adjuvant to brachial plexus block, there is no clear consensus for its optimal dose. We compared 2 different doses of dexmedetomidine (1mcg/kg Vs 2mc...
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College of Medical Sciences
2018-09-01
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| Series: | Journal of College of Medical Sciences-Nepal |
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| Online Access: | https://www.nepjol.info/index.php/JCMSN/article/view/20908 |
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| author | Jeevan Singh Samir Shakya Anuranjan Ghimire Sanjay Saha Parikshit Bikram Singh |
| author_facet | Jeevan Singh Samir Shakya Anuranjan Ghimire Sanjay Saha Parikshit Bikram Singh |
| author_sort | Jeevan Singh |
| collection | DOAJ |
| description | <p><strong>Background:</strong> Though, various studies have been conducted to show the efficacy of dexmedetomidine as an adjuvant to brachial plexus block, there is no clear consensus for its optimal dose. We compared 2 different doses of dexmedetomidine (1mcg/kg Vs 2mcg/kg) with ropivaciane in USG guided brachial plexus block for the quality of anesthesia and analgesia. <strong>Materials and Methods:</strong> Fifty patients (18-50years, 50-60kgs), ASA PS I and II undergoing surgery of upper limb were enrolled in this prospective, double blind, randomized control trial. Group Rd received 19ml of 0.5% Ropivaciane with 1mcg/kg of dexmedetomidine (total 20ml), and Group RD received 19ml of 0.5% Ropivacaine with 2mcg/kg of dexmedetomidine (total 20ml). Onset and duration of sensory and motor block, duration of analgesia, sedation score, hemodyanamic changes were compared. We also monitored for various un towards effects.<strong> Results:</strong> The onset time of sensory and motor block (9.36±1.114 mins and 14.40 ± 1.528 mins in group Rd vs 8.32 ±0.945 mins and 12.40 ± 1.21 mins in group RD) were not significantly different between two groups (p-value > 0.05).The duration of sensory and motor block (596.20 ± 76.859 mins and 541.20±81.564 mins in group Rd vs 730.80 + 65.187 mins and 659.80±93.607 mins in group RD) were not significantly longer in group RD than group Rd (p-value > 0.05). The duration of analgesia (626.00±70.475 mins in group Rd vs 754.00±60.139 mins in group RD) were not significantly longer in group RD than group Rd (p-value > 0.05). Hemodynamic parameters were also comparable between two groups (p-value >0.05) but 3 patients in RD group (2mcg/kg) developed bradycardia and required treatment with atropine whereas in Rd group (1mcg/kg) none developed bradycardia.<strong> Conclusions:</strong> There is no significant difference in the onset and duration of block between the two groups. However, higher dose of dexmedetomidine is associated bradycardia. Hence, in comparision with 2mcg/kg, 1mcg/kg of dexmedetomidine is better adjuvant to 0.5% ropivaciane in terms of safety and effectiveness.</p><p><strong>Keywords:</strong> dexmedetomidine; ropivacaine; supraclavicular brachial plexus block.</p><p> </p> |
| first_indexed | 2024-04-13T03:06:13Z |
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| issn | 2091-0657 2091-0673 |
| language | English |
| last_indexed | 2024-04-13T03:06:13Z |
| publishDate | 2018-09-01 |
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| spelling | doaj.art-26221854fac24d29b5050a91eec2dac72022-12-22T03:05:13ZengCollege of Medical SciencesJournal of College of Medical Sciences-Nepal2091-06572091-06732018-09-0114312713110.3126/jcmsn.v14i3.2090816711A Comparative Study Between Two Different Doses of Dexmedetomidine Combined with Ropivacaine in Ultrasound Guided Supraclavicular Brachial Plexus BlockJeevan Singh0Samir ShakyaAnuranjan GhimireSanjay SahaParikshit Bikram SinghKathmandu University School of medical sciences.<p><strong>Background:</strong> Though, various studies have been conducted to show the efficacy of dexmedetomidine as an adjuvant to brachial plexus block, there is no clear consensus for its optimal dose. We compared 2 different doses of dexmedetomidine (1mcg/kg Vs 2mcg/kg) with ropivaciane in USG guided brachial plexus block for the quality of anesthesia and analgesia. <strong>Materials and Methods:</strong> Fifty patients (18-50years, 50-60kgs), ASA PS I and II undergoing surgery of upper limb were enrolled in this prospective, double blind, randomized control trial. Group Rd received 19ml of 0.5% Ropivaciane with 1mcg/kg of dexmedetomidine (total 20ml), and Group RD received 19ml of 0.5% Ropivacaine with 2mcg/kg of dexmedetomidine (total 20ml). Onset and duration of sensory and motor block, duration of analgesia, sedation score, hemodyanamic changes were compared. We also monitored for various un towards effects.<strong> Results:</strong> The onset time of sensory and motor block (9.36±1.114 mins and 14.40 ± 1.528 mins in group Rd vs 8.32 ±0.945 mins and 12.40 ± 1.21 mins in group RD) were not significantly different between two groups (p-value > 0.05).The duration of sensory and motor block (596.20 ± 76.859 mins and 541.20±81.564 mins in group Rd vs 730.80 + 65.187 mins and 659.80±93.607 mins in group RD) were not significantly longer in group RD than group Rd (p-value > 0.05). The duration of analgesia (626.00±70.475 mins in group Rd vs 754.00±60.139 mins in group RD) were not significantly longer in group RD than group Rd (p-value > 0.05). Hemodynamic parameters were also comparable between two groups (p-value >0.05) but 3 patients in RD group (2mcg/kg) developed bradycardia and required treatment with atropine whereas in Rd group (1mcg/kg) none developed bradycardia.<strong> Conclusions:</strong> There is no significant difference in the onset and duration of block between the two groups. However, higher dose of dexmedetomidine is associated bradycardia. Hence, in comparision with 2mcg/kg, 1mcg/kg of dexmedetomidine is better adjuvant to 0.5% ropivaciane in terms of safety and effectiveness.</p><p><strong>Keywords:</strong> dexmedetomidine; ropivacaine; supraclavicular brachial plexus block.</p><p> </p>https://www.nepjol.info/index.php/JCMSN/article/view/20908Dexmedetomidine, Ropivacaine, Supraclavicular brachial plexus block |
| spellingShingle | Jeevan Singh Samir Shakya Anuranjan Ghimire Sanjay Saha Parikshit Bikram Singh A Comparative Study Between Two Different Doses of Dexmedetomidine Combined with Ropivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block Journal of College of Medical Sciences-Nepal Dexmedetomidine, Ropivacaine, Supraclavicular brachial plexus block |
| title | A Comparative Study Between Two Different Doses of Dexmedetomidine Combined with Ropivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block |
| title_full | A Comparative Study Between Two Different Doses of Dexmedetomidine Combined with Ropivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block |
| title_fullStr | A Comparative Study Between Two Different Doses of Dexmedetomidine Combined with Ropivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block |
| title_full_unstemmed | A Comparative Study Between Two Different Doses of Dexmedetomidine Combined with Ropivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block |
| title_short | A Comparative Study Between Two Different Doses of Dexmedetomidine Combined with Ropivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block |
| title_sort | comparative study between two different doses of dexmedetomidine combined with ropivacaine in ultrasound guided supraclavicular brachial plexus block |
| topic | Dexmedetomidine, Ropivacaine, Supraclavicular brachial plexus block |
| url | https://www.nepjol.info/index.php/JCMSN/article/view/20908 |
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