| Summary: | In the literature, many cases of abnormal uterine bleeding associated with selective serotonin reuptake inhibitors have been reported as a side effect of antidepressant treatment. However, abnormal uterine bleeding associated with bupropion, a norepinephrine-dopamine reuptake inhibitor, has been reported in only two case studies to date. A 28-year-old, oligomenorrheic female patient was admitted to the psychiatry department with the symptoms of depression. The patient was diagnosed with major depression and bupropion 150 mg/day was prescribed. After the initiation of the treatment, the patient experienced mild-to-moderate uterine bleeding, which was resolved with the discontinuation of the drug. In the patient’s anamnesis, it was learned that the same side effect had developed with the previous bupropion treatment. A comprehensive examination of the patient suggested that this adverse effect could strongly be associated with bupropion. This case supports the view that antidepressants can cause bleeding abnormalities, in particular vaginal bleeding caused by bupropion usage. Physicians who prescribe bupropion should carefully follow up their patients to identify such adverse effects.
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