Arterial stiffness is associated with cancer mortality: Insight from Kailuan study
Abstract Background There is limited evidence on the association between arterial stenosis and the risk of all‐cause mortality in cancer patients (ACMC). This study investigated whether the status of arterial function and structure measured by brachial–ankle pulse wave velocity (baPWV) is associated...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.6251 |
| _version_ | 1827386708089372672 |
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| author | Jiatian Li Tesfaldet Habtemariam Hidru Yajuan Lin Xinying Wang Li Lin Shuohua Chen Yunlong Xia Xiaolei Yang Shouling Wu |
| author_facet | Jiatian Li Tesfaldet Habtemariam Hidru Yajuan Lin Xinying Wang Li Lin Shuohua Chen Yunlong Xia Xiaolei Yang Shouling Wu |
| author_sort | Jiatian Li |
| collection | DOAJ |
| description | Abstract Background There is limited evidence on the association between arterial stenosis and the risk of all‐cause mortality in cancer patients (ACMC). This study investigated whether the status of arterial function and structure measured by brachial–ankle pulse wave velocity (baPWV) is associated with ACMC. Methods A total of 43,943 Chinese adults underwent a baPWV examination. Cox proportional hazards model was used to assess the association between the baPWV values and ACMC. Results During a total follow‐up duration of 3.81 ± 2.50 years, there were 157 deaths among 553 cancer cases diagnosed during the follow‐up. Patients with baPWV ≥18 m/s showed an increased risk of ACMC compared to patients with ideal vascular function. In the multivariate‐adjusted model, we observed a significant association between arterial stiffness severity and ACMC with a hazard ratio (HR) 2.72 (95% confidence interval [CI]: 1.55–4.80; p < 0.001) in those with baPWV ≥18 m/s. With a 1‐SD increase in baPWV, the HR (95% CI) for ACMC in the entire cohort, men, and patients ≤60 years old were 1.20 (95% CI: 1.03–1.41; p < 0.05), 1.20 (95% CI: 1.01–1.43; p < 0.05), and 1.44 (95% CI: 1.10–1.44; p = 0.008), respectively. Conclusions Increased arterial stiffness measured by baPWV is associated with ACMC. The association between high baPWV (≥18 m/s) and risk of all‐cause mortality was prominent in men and those ≤60 years of age. |
| first_indexed | 2024-03-08T15:50:27Z |
| format | Article |
| id | doaj.art-2624187f4d9d424a820b58c2d1049a5e |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-08T15:50:27Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-2624187f4d9d424a820b58c2d1049a5e2024-01-09T05:41:08ZengWileyCancer Medicine2045-76342023-08-011215165801659010.1002/cam4.6251Arterial stiffness is associated with cancer mortality: Insight from Kailuan studyJiatian Li0Tesfaldet Habtemariam Hidru1Yajuan Lin2Xinying Wang3Li Lin4Shuohua Chen5Yunlong Xia6Xiaolei Yang7Shouling Wu8Department of Cardiology, Institute of Cardiovascular Diseases First Affiliated Hospital of Dalian Medical University Dalian ChinaDepartment of Cardiology, Institute of Cardiovascular Diseases First Affiliated Hospital of Dalian Medical University Dalian ChinaDepartment of Cardiology, Institute of Cardiovascular Diseases First Affiliated Hospital of Dalian Medical University Dalian ChinaDepartment of Cardiology, Institute of Cardiovascular Diseases First Affiliated Hospital of Dalian Medical University Dalian ChinaDepartment of Cardiology, Institute of Cardiovascular Diseases First Affiliated Hospital of Dalian Medical University Dalian ChinaHealth Department of Kailuan Group Tangshan ChinaDepartment of Cardiology, Institute of Cardiovascular Diseases First Affiliated Hospital of Dalian Medical University Dalian ChinaDepartment of Cardiology, Institute of Cardiovascular Diseases First Affiliated Hospital of Dalian Medical University Dalian ChinaDepartment of Cardiology, Kailuan General Hospital North China University of Science and Technology Tangshan ChinaAbstract Background There is limited evidence on the association between arterial stenosis and the risk of all‐cause mortality in cancer patients (ACMC). This study investigated whether the status of arterial function and structure measured by brachial–ankle pulse wave velocity (baPWV) is associated with ACMC. Methods A total of 43,943 Chinese adults underwent a baPWV examination. Cox proportional hazards model was used to assess the association between the baPWV values and ACMC. Results During a total follow‐up duration of 3.81 ± 2.50 years, there were 157 deaths among 553 cancer cases diagnosed during the follow‐up. Patients with baPWV ≥18 m/s showed an increased risk of ACMC compared to patients with ideal vascular function. In the multivariate‐adjusted model, we observed a significant association between arterial stiffness severity and ACMC with a hazard ratio (HR) 2.72 (95% confidence interval [CI]: 1.55–4.80; p < 0.001) in those with baPWV ≥18 m/s. With a 1‐SD increase in baPWV, the HR (95% CI) for ACMC in the entire cohort, men, and patients ≤60 years old were 1.20 (95% CI: 1.03–1.41; p < 0.05), 1.20 (95% CI: 1.01–1.43; p < 0.05), and 1.44 (95% CI: 1.10–1.44; p = 0.008), respectively. Conclusions Increased arterial stiffness measured by baPWV is associated with ACMC. The association between high baPWV (≥18 m/s) and risk of all‐cause mortality was prominent in men and those ≤60 years of age.https://doi.org/10.1002/cam4.6251arterial stiffnesscancermalignancymortality |
| spellingShingle | Jiatian Li Tesfaldet Habtemariam Hidru Yajuan Lin Xinying Wang Li Lin Shuohua Chen Yunlong Xia Xiaolei Yang Shouling Wu Arterial stiffness is associated with cancer mortality: Insight from Kailuan study Cancer Medicine arterial stiffness cancer malignancy mortality |
| title | Arterial stiffness is associated with cancer mortality: Insight from Kailuan study |
| title_full | Arterial stiffness is associated with cancer mortality: Insight from Kailuan study |
| title_fullStr | Arterial stiffness is associated with cancer mortality: Insight from Kailuan study |
| title_full_unstemmed | Arterial stiffness is associated with cancer mortality: Insight from Kailuan study |
| title_short | Arterial stiffness is associated with cancer mortality: Insight from Kailuan study |
| title_sort | arterial stiffness is associated with cancer mortality insight from kailuan study |
| topic | arterial stiffness cancer malignancy mortality |
| url | https://doi.org/10.1002/cam4.6251 |
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