Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency.

Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency.

As part of the Nucleotide Excision Repair (NER) process, the endonuclease XPG is involved in repair of helix-distorting DNA lesions, but the protein has also been implicated in several other DNA repair systems, complicating genotype-phenotype relationship in XPG patients. Defects in XPG can cause ei...

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Main Authors: Sander Barnhoorn, Lieneke M Uittenboogaard, Dick Jaarsma, Wilbert P Vermeij, Maria Tresini, Michael Weymaere, Hervé Menoni, Renata M C Brandt, Monique C de Waard, Sander M Botter, Altaf H Sarker, Nicolaas G J Jaspers, Gijsbertus T J van der Horst, Priscilla K Cooper, Jan H J Hoeijmakers, Ingrid van der Pluijm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4191938?pdf=render

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