No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study
Wei-Hua Li,1 Zi-Guan Zhang,1 Zheng-Rong Huang,1 Wei Zhang,1 Zhi-Bin Li,2 Zhong-Quan Qi3 1Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, Xiamen 361003, People’s Republic of China; 2Epidemiology Research Unit, The First Affiliated Hospital of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-09-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/no-association-between-tumor-laterality-and-cardiac-related-mortality--peer-reviewed-article-CMAR |
| _version_ | 1828393194603151360 |
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| author | Li WH Zhang ZG Huang ZR Zhang W Li ZB Qi ZQ |
| author_facet | Li WH Zhang ZG Huang ZR Zhang W Li ZB Qi ZQ |
| author_sort | Li WH |
| collection | DOAJ |
| description | Wei-Hua Li,1 Zi-Guan Zhang,1 Zheng-Rong Huang,1 Wei Zhang,1 Zhi-Bin Li,2 Zhong-Quan Qi3 1Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, Xiamen 361003, People’s Republic of China; 2Epidemiology Research Unit, The First Affiliated Hospital of Xiamen University, Xiamen 361003, People’s Republic of China; 3Organ Transplantation Institute, Medical College, Xiamen University, Xiamen 361005, People’s Republic of China Introduction: To assess the effect of tumor laterality to cardiac-related deaths of breast cancer in the current radiation practices using a large modern population-based study.Methods: Women diagnosed with breast cancer from 2000 to 2008 were included using the current Surveillance, Epidemiology, and End Results database. The primary outcome of this study was the cardiac-related mortality. Multivariate analysis was performed using the Cox proportional hazards model to analyze the cardiac-related mortality including demographic, clinicopathologic, and treatment factors.Results: We identified 168,761 breast cancer patients, including 85,006 (50.4%) patients with left-sided tumors and 83,755 (49.6%) patients with right-sided tumors. The median follow-up period was 8.8 years. The 10-year cardiac-related mortality was 2.3% and 2.3% in left- and right-sided tumors, respectively (P=0.685). The results indicated that patients with older age, non-Hispanic Black, receipt of mastectomy, and married status were the independent adverse factors for cardiac-related mortality. However, left-sided tumors were not associated to a higher risk of cardiac-related mortality than right-sided tumors following postoperative radiotherapy (right vs left, hazard ratios 1.025, 95% CI 0.856–1.099, P=0.484). The risk of cardiac-related mortality in the entire cohort was increased with the extension of follow-up time. However, there was still not significantly different between left- and right-sided tumors. Subgroup analysis also found no association between tumor laterality and cardiac-related mortality after postoperative radiotherapy based on various demographics and treatment factors.Conclusion: With a median follow-up of 8.8 years, no significant differences were found in cardiac-related mortality between left- and right-sided tumors under current radiation practices of breast cancer patients. Keywords: breast cancer, radiotherapy, tumor laterality, cardiac mortality |
| first_indexed | 2024-12-10T07:33:43Z |
| format | Article |
| id | doaj.art-2627b5fd69b5429bbdb4269482a4331b |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-10T07:33:43Z |
| publishDate | 2018-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-2627b5fd69b5429bbdb4269482a4331b2022-12-22T01:57:28ZengDove Medical PressCancer Management and Research1179-13222018-09-01Volume 103649365640691No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based studyLi WHZhang ZGHuang ZRZhang WLi ZBQi ZQWei-Hua Li,1 Zi-Guan Zhang,1 Zheng-Rong Huang,1 Wei Zhang,1 Zhi-Bin Li,2 Zhong-Quan Qi3 1Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, Xiamen 361003, People’s Republic of China; 2Epidemiology Research Unit, The First Affiliated Hospital of Xiamen University, Xiamen 361003, People’s Republic of China; 3Organ Transplantation Institute, Medical College, Xiamen University, Xiamen 361005, People’s Republic of China Introduction: To assess the effect of tumor laterality to cardiac-related deaths of breast cancer in the current radiation practices using a large modern population-based study.Methods: Women diagnosed with breast cancer from 2000 to 2008 were included using the current Surveillance, Epidemiology, and End Results database. The primary outcome of this study was the cardiac-related mortality. Multivariate analysis was performed using the Cox proportional hazards model to analyze the cardiac-related mortality including demographic, clinicopathologic, and treatment factors.Results: We identified 168,761 breast cancer patients, including 85,006 (50.4%) patients with left-sided tumors and 83,755 (49.6%) patients with right-sided tumors. The median follow-up period was 8.8 years. The 10-year cardiac-related mortality was 2.3% and 2.3% in left- and right-sided tumors, respectively (P=0.685). The results indicated that patients with older age, non-Hispanic Black, receipt of mastectomy, and married status were the independent adverse factors for cardiac-related mortality. However, left-sided tumors were not associated to a higher risk of cardiac-related mortality than right-sided tumors following postoperative radiotherapy (right vs left, hazard ratios 1.025, 95% CI 0.856–1.099, P=0.484). The risk of cardiac-related mortality in the entire cohort was increased with the extension of follow-up time. However, there was still not significantly different between left- and right-sided tumors. Subgroup analysis also found no association between tumor laterality and cardiac-related mortality after postoperative radiotherapy based on various demographics and treatment factors.Conclusion: With a median follow-up of 8.8 years, no significant differences were found in cardiac-related mortality between left- and right-sided tumors under current radiation practices of breast cancer patients. Keywords: breast cancer, radiotherapy, tumor laterality, cardiac mortalityhttps://www.dovepress.com/no-association-between-tumor-laterality-and-cardiac-related-mortality--peer-reviewed-article-CMARBreast cancerradiotherapytumor lateralitycardiac mortality |
| spellingShingle | Li WH Zhang ZG Huang ZR Zhang W Li ZB Qi ZQ No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study Cancer Management and Research Breast cancer radiotherapy tumor laterality cardiac mortality |
| title | No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study |
| title_full | No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study |
| title_fullStr | No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study |
| title_full_unstemmed | No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study |
| title_short | No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study |
| title_sort | no association between tumor laterality and cardiac related mortality in breast cancer patients after radiotherapy a population based study |
| topic | Breast cancer radiotherapy tumor laterality cardiac mortality |
| url | https://www.dovepress.com/no-association-between-tumor-laterality-and-cardiac-related-mortality--peer-reviewed-article-CMAR |
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