Evaluation of remote results of surgical treatment of nodular endemic goiter with autoimmune thyroiditis
Introduction. Autoimmune thyroiditis is one of the most important problems of modern endocrinology, with inadequately studied etiological and pathogenic mechanisms of development. It is characterized by the lack of objective and reliable diagnostic methods, effective treatment methods, uncertain the...
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Balkan Medical Union
2018-12-01
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| Series: | Archives of the Balkan Medical Union |
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| Online Access: | https://umbalk.org/wp-content/uploads/2018/12/08.EVALUATION-OF-REMOTE-RESULTS-OF-SURGICAL-TREATMENT.pdf |
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| author | Michael I. SHEREMET Viktor O. SHIDLOVSKYI Olexandr V. SHIDLOVSKYI Vitaliy V. MAKSYMYUK Volodimir V. TARABANCHUK Nina P. TKACHUK Oleksandr V. BILOOKY Hana Ya. STUPNYTSKA Galina V. GRYGORUK Igor O. MALISHEVSKY Lalita M. HERASYM Ala A. HALAHDYNA Ivanna I. ABRAMCHUK Natalia V. VATAMANYUK |
| author_facet | Michael I. SHEREMET Viktor O. SHIDLOVSKYI Olexandr V. SHIDLOVSKYI Vitaliy V. MAKSYMYUK Volodimir V. TARABANCHUK Nina P. TKACHUK Oleksandr V. BILOOKY Hana Ya. STUPNYTSKA Galina V. GRYGORUK Igor O. MALISHEVSKY Lalita M. HERASYM Ala A. HALAHDYNA Ivanna I. ABRAMCHUK Natalia V. VATAMANYUK |
| author_sort | Michael I. SHEREMET |
| collection | DOAJ |
| description | Introduction. Autoimmune thyroiditis is one of the most important problems of modern endocrinology, with inadequately studied etiological and pathogenic mechanisms of development. It is characterized by the lack of objective and reliable diagnostic methods, effective treatment methods, uncertain therapy or indications for the choice of treatment methods.
The aim of the study. Determination of markers for prediction of clinical course and choice of surgery’ volume in patients with nodular goiter and autoimmune thyroiditis, taking into account the oxidative, autoimmune and apoptotic processes.
Material and methods. A total of 95 patients who were operated for a nodular endemic goiter on the background of autoimmune thyroiditis were examined. The status of pro- and antioxidant systems, the activity of proinflammatory cytokines, hormonal function of thyroid gland, the level of antibodies to thyroperoxidase, thyroglobulin antibodies and ultrasound structural changes in the thyroid gland have been evaluated in all patients, before and after surgery.
Results. In patients with nodular endemic goiter and autoimmune thyroiditis, in the remote period after surgical treatment, there is a significant increase in the peroxide oxidation index and a decrease in the activity of antioxidant defense systems, against the suppression of apoptotic processes and the activation of pro-inflammatory cytokines. These processes lead to functional failure, hyperplasia and the progression of structural thyroid abnormalities, with progression of the functional incapacity of the thyroid gland and inadequate long-term outcome of treatment.
Conclusions. The study allowed to clarify the indications and contraindications of different methods of treatment in patients with NGAIT, taking into account the parameters of severity of peroxide oxidation processes, the activity of apoptosis and functional capacity of the gland. |
| first_indexed | 2024-12-22T00:17:19Z |
| format | Article |
| id | doaj.art-2627b7b72dd1490ba6b0098328966ac4 |
| institution | Directory Open Access Journal |
| issn | 1584-9244 2558-815X |
| language | English |
| last_indexed | 2024-12-22T00:17:19Z |
| publishDate | 2018-12-01 |
| publisher | Balkan Medical Union |
| record_format | Article |
| series | Archives of the Balkan Medical Union |
| spelling | doaj.art-2627b7b72dd1490ba6b0098328966ac42022-12-21T18:45:16ZengBalkan Medical UnionArchives of the Balkan Medical Union1584-92442558-815X2018-12-0153453554310.31688/AMBU.2018.53.Evaluation of remote results of surgical treatment of nodular endemic goiter with autoimmune thyroiditisMichael I. SHEREMET0 Viktor O. SHIDLOVSKYI1 Olexandr V. SHIDLOVSKYI2Vitaliy V. MAKSYMYUK3 Volodimir V. TARABANCHUK4Nina P. TKACHUK5Oleksandr V. BILOOKY6Hana Ya. STUPNYTSKA7Galina V. GRYGORUK8Igor O. MALISHEVSKY9 Lalita M. HERASYM10 Ala A. HALAHDYNA11 Ivanna I. ABRAMCHUK12 Natalia V. VATAMANYUK13Surgery Department No 1, Bukovinian State Medical University, Ukraine Surgery Department, I.Y. Horbachevsky State Medical University, UkraineSurgery Department, I.Y. Horbachevsky State Medical University, Ukraine Surgery Department No 1, Bukovinian State Medical University, UkraineSurgery Department No 1, Bukovinian State Medical University, UkraineSurgery Department No 1, Bukovinian State Medical University, UkraineSurgery Department No 1, Bukovinian State Medical University, Ukraine Department of internal medicine and infectious diseases, Bukovinian State Medical University, Ukraine Department of General Practice (Family Medicine), Physical Rehabilitation and Sports Medicine, Ivano-Frankivsk National Medical University, Ukraine Department of Oncology and Radiology, Bukovinian State Medical University, Ukraine Department of Surgical Dentistry and Maxillofacial Surgery, Bukovinian State Medical University,Ukraine Department of Surgical Dentistry and Maxillofacial Surgery, Bukovinian State Medical University,Ukraine 7 Department of Therapeutic Stomatology, Bukovinian State Medical University 7 Department of Therapeutic Stomatology, Bukovinian State Medical UniversityIntroduction. Autoimmune thyroiditis is one of the most important problems of modern endocrinology, with inadequately studied etiological and pathogenic mechanisms of development. It is characterized by the lack of objective and reliable diagnostic methods, effective treatment methods, uncertain therapy or indications for the choice of treatment methods. The aim of the study. Determination of markers for prediction of clinical course and choice of surgery’ volume in patients with nodular goiter and autoimmune thyroiditis, taking into account the oxidative, autoimmune and apoptotic processes. Material and methods. A total of 95 patients who were operated for a nodular endemic goiter on the background of autoimmune thyroiditis were examined. The status of pro- and antioxidant systems, the activity of proinflammatory cytokines, hormonal function of thyroid gland, the level of antibodies to thyroperoxidase, thyroglobulin antibodies and ultrasound structural changes in the thyroid gland have been evaluated in all patients, before and after surgery. Results. In patients with nodular endemic goiter and autoimmune thyroiditis, in the remote period after surgical treatment, there is a significant increase in the peroxide oxidation index and a decrease in the activity of antioxidant defense systems, against the suppression of apoptotic processes and the activation of pro-inflammatory cytokines. These processes lead to functional failure, hyperplasia and the progression of structural thyroid abnormalities, with progression of the functional incapacity of the thyroid gland and inadequate long-term outcome of treatment. Conclusions. The study allowed to clarify the indications and contraindications of different methods of treatment in patients with NGAIT, taking into account the parameters of severity of peroxide oxidation processes, the activity of apoptosis and functional capacity of the gland.https://umbalk.org/wp-content/uploads/2018/12/08.EVALUATION-OF-REMOTE-RESULTS-OF-SURGICAL-TREATMENT.pdfnodular endemic goiterautoimmune thyroiditisapoptosiscytokinesperoxidationsurgery volume |
| spellingShingle | Michael I. SHEREMET Viktor O. SHIDLOVSKYI Olexandr V. SHIDLOVSKYI Vitaliy V. MAKSYMYUK Volodimir V. TARABANCHUK Nina P. TKACHUK Oleksandr V. BILOOKY Hana Ya. STUPNYTSKA Galina V. GRYGORUK Igor O. MALISHEVSKY Lalita M. HERASYM Ala A. HALAHDYNA Ivanna I. ABRAMCHUK Natalia V. VATAMANYUK Evaluation of remote results of surgical treatment of nodular endemic goiter with autoimmune thyroiditis Archives of the Balkan Medical Union nodular endemic goiter autoimmune thyroiditis apoptosis cytokines peroxidation surgery volume |
| title | Evaluation of remote results of surgical treatment of nodular endemic goiter with autoimmune thyroiditis |
| title_full | Evaluation of remote results of surgical treatment of nodular endemic goiter with autoimmune thyroiditis |
| title_fullStr | Evaluation of remote results of surgical treatment of nodular endemic goiter with autoimmune thyroiditis |
| title_full_unstemmed | Evaluation of remote results of surgical treatment of nodular endemic goiter with autoimmune thyroiditis |
| title_short | Evaluation of remote results of surgical treatment of nodular endemic goiter with autoimmune thyroiditis |
| title_sort | evaluation of remote results of surgical treatment of nodular endemic goiter with autoimmune thyroiditis |
| topic | nodular endemic goiter autoimmune thyroiditis apoptosis cytokines peroxidation surgery volume |
| url | https://umbalk.org/wp-content/uploads/2018/12/08.EVALUATION-OF-REMOTE-RESULTS-OF-SURGICAL-TREATMENT.pdf |
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