Translation From Mice to Men: Are Dogs a Dodgy Intermediate?
Alternatives for liver transplantation in severe liver disease are urgently needed in view of the limited availability of donor livers. The use of embryonic stem cells (ES) or hepatic progenitor cells (HPC) has been investigated in mice models of acute and chronic liver failure. To extrapolate the f...
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| Format: | Article |
| Language: | English |
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European Medical Journal
2014-05-01
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| Series: | European Medical Journal Hepatology |
| Subjects: | |
| Online Access: | http://emjreviews.com/wp-content/uploads/TRANSLATION-FROM-MICE-TO-MEN-ARE-DOGS-A-DODGY-INTERMEDIATE.pdf |
| _version_ | 1818247831151968256 |
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| author | Hedwig S. Kruitwagen Bart Spee Hille Fieten Frank G. van Steenbeek Baukje A. Schotanus Louis C. Penning |
| author_facet | Hedwig S. Kruitwagen Bart Spee Hille Fieten Frank G. van Steenbeek Baukje A. Schotanus Louis C. Penning |
| author_sort | Hedwig S. Kruitwagen |
| collection | DOAJ |
| description | Alternatives for liver transplantation in severe liver disease are urgently needed in view of the limited availability of donor livers. The use of embryonic stem cells (ES) or hepatic progenitor cells (HPC) has been investigated in mice models of acute and chronic liver failure. To extrapolate the findings in inbred mouse strains (weighing around 20 g, with a maximal lifespan of 3 years) to the genetically more variable human beings (around 3,000-fold heavier and living 30 times longer), does seem a bit of a large step. This article describes recent developments in HPC research in dogs and compares these findings to experimental rodent studies and human pathology. Recent progress in canine liver stem cell research and canine genetics are combined to exemplify their possible role as a relevant animal model for the feasibility of stem cell transplantation in human liver failure. |
| first_indexed | 2024-12-12T15:10:57Z |
| format | Article |
| id | doaj.art-262b0b46a50349f095c9fcb7b404828a |
| institution | Directory Open Access Journal |
| issn | 2053-4221 |
| language | English |
| last_indexed | 2024-12-12T15:10:57Z |
| publishDate | 2014-05-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal Hepatology |
| spelling | doaj.art-262b0b46a50349f095c9fcb7b404828a2022-12-22T00:20:37ZengEuropean Medical JournalEuropean Medical Journal Hepatology2053-42212014-05-01214854Translation From Mice to Men: Are Dogs a Dodgy Intermediate?Hedwig S. Kruitwagen0Bart Spee1Hille Fieten2Frank G. van Steenbeek3Baukje A. Schotanus4Louis C. Penning5Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, Utrecht, the NetherlandsDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, Utrecht, the NetherlandsDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, Utrecht, the NetherlandsDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, Utrecht, the NetherlandsDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, Utrecht, the NetherlandsDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, Utrecht, the NetherlandsAlternatives for liver transplantation in severe liver disease are urgently needed in view of the limited availability of donor livers. The use of embryonic stem cells (ES) or hepatic progenitor cells (HPC) has been investigated in mice models of acute and chronic liver failure. To extrapolate the findings in inbred mouse strains (weighing around 20 g, with a maximal lifespan of 3 years) to the genetically more variable human beings (around 3,000-fold heavier and living 30 times longer), does seem a bit of a large step. This article describes recent developments in HPC research in dogs and compares these findings to experimental rodent studies and human pathology. Recent progress in canine liver stem cell research and canine genetics are combined to exemplify their possible role as a relevant animal model for the feasibility of stem cell transplantation in human liver failure.http://emjreviews.com/wp-content/uploads/TRANSLATION-FROM-MICE-TO-MEN-ARE-DOGS-A-DODGY-INTERMEDIATE.pdfcell transplantationinherited diseases.Liverprogenitor cell |
| spellingShingle | Hedwig S. Kruitwagen Bart Spee Hille Fieten Frank G. van Steenbeek Baukje A. Schotanus Louis C. Penning Translation From Mice to Men: Are Dogs a Dodgy Intermediate? European Medical Journal Hepatology cell transplantation inherited diseases. Liver progenitor cell |
| title | Translation From Mice to Men: Are Dogs a Dodgy Intermediate? |
| title_full | Translation From Mice to Men: Are Dogs a Dodgy Intermediate? |
| title_fullStr | Translation From Mice to Men: Are Dogs a Dodgy Intermediate? |
| title_full_unstemmed | Translation From Mice to Men: Are Dogs a Dodgy Intermediate? |
| title_short | Translation From Mice to Men: Are Dogs a Dodgy Intermediate? |
| title_sort | translation from mice to men are dogs a dodgy intermediate |
| topic | cell transplantation inherited diseases. Liver progenitor cell |
| url | http://emjreviews.com/wp-content/uploads/TRANSLATION-FROM-MICE-TO-MEN-ARE-DOGS-A-DODGY-INTERMEDIATE.pdf |
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